3,390 research outputs found
An Authorisation Scenario for S-OGSA
The Semantic Grid initiative aims to exploit knowledge in the Grid to increase the automation, interoperability and flexibility of Grid middleware and applications. To bring a principled approach to developing Semantic Grid Systems, and to outline their core capabilities and behaviors, we have devised a reference Semantic Grid Architecture called S-OGSA. We present the implementation of an S-OGSA observant semantically-enabled Grid authorization scenario, which demonstrates two aspects: 1) the roles of different middleware components, be them semantic or non-semantic, and 2) the utility of explicit semantics for undertaking an essential activity in the Grid: resource access control
Underlap counterdoping as an efficient means to suppress lateral leakage in the electron\u2013hole bilayer tunnel FET
The electron\u2013hole bilayer tunnel (EHBTFET)\uf0a0has been proposed as a density of states (DOS)
switch capable of achieving a subthreshold slope lower than 60mV/decade at room temperature;
however, one of the main challenges is the control of the lateral band-to-band tunneling (BTBT)
leakage in the OFF state. In this work, we show that by using oppositely doped underlap regions;
the unwanted penetration of the wavefunction into the underlap region at low gate biases is
prevented; thereby drastically reducing the lateral BTBT leakage without any penalty on the ON
current. The method is verified using a full-quantum 2D Schr\uf6dinger\u2013Poisson solver under the
effective mass approximation. For a channel thickness of 10 nm, an In0.53Ga0.47As EHBTFET
with counterdoping can exhibit an ON-current up to 20 mA mm and an average subthreshold
swing (SS) of about 30 mV/dec. Compared to previous lateral leakage suppression solutions, the
proposed method can be fabricated using template-assisted selective epitaxy
Effect of kinetic resonances on the stability of Resistive Wall Mode in Reversed Field Pinch
The kinetic effects, due to the mode resonance with thermal particle drift
motions in the reversed field pinch (RFP) plasmas, are numerically investigated
for the stability of the resistive wall mode, using a non-perturbative
MHD-kinetic hybrid formulation. The kinetic effects are generally found too
weak to substantially change the mode growth rate, or the stability margin,
re-enforcing the fact that the ideal MHD model is rather adequate for
describing the RWM physics in RFP experiments.Comment: Submitted to: Plasma Phys. Control. Fusio
Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder.
Abstract
OBJECTIVE:
To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.
METHODS:
Multicenter retrospective study of 16 children with NMO/NMOSD receiving 652 rituximab courses. According to CD19 counts, events during rituximab were categorized as "repopulation," "depletion," or "depletion failure" relapses (repopulation threshold CD19 6510
7 10(6) cells/L).
RESULTS:
The 16 patients (14 girls; mean age 9.6 years, range 1.8-15.3) had a mean of 6.1 events (range 1-11) during a mean follow-up of 6.1 years (range 1.6-13.6) and received a total of 76 rituximab courses (mean 4.7, range 2-9) in 42.6-year cohort treatment. Before rituximab, 62.5% had received azathioprine, mycophenolate mofetil, or cyclophosphamide. Mean time from rituximab to last documented B cell depletion and first repopulation was 4.5 and 6.8 months, respectively, with large interpatient variability. Earliest repopulations occurred with the lowest doses. Significant reduction between pre- and post-rituximab annualized relapse rate (ARR) was observed (p = 0.003). During rituximab, 6 patients were relapse-free, although 21 relapses occurred in 10 patients, including 13 "repopulation," 3 "depletion," and 4 "depletion failure" relapses. Of the 13 "repopulation" relapses, 4 had CD19 10-50
7 10(6) cells/L, 10 had inadequate monitoring ( 641 CD19 in the 4 months before relapses), and 5 had delayed redosing after repopulation detection.
CONCLUSION:
Rituximab is effective in relapse prevention, but B cell repopulation creates a risk of relapse. Redosing before B cell repopulation could reduce the relapse risk further.
CLASSIFICATION OF EVIDENCE:
This study provides Class IV evidence that rituximab significantly reduces ARR in pediatric NMO/NMOSD. This study also demonstrates a relationship between B cell repopulation and relapses
Stratifying quotient stacks and moduli stacks
Recent results in geometric invariant theory (GIT) for non-reductive linear
algebraic group actions allow us to stratify quotient stacks of the form [X/H],
where X is a projective scheme and H is a linear algebraic group with
internally graded unipotent radical acting linearly on X, in such a way that
each stratum [S/H] has a geometric quotient S/H. This leads to stratifications
of moduli stacks (for example, sheaves over a projective scheme) such that each
stratum has a coarse moduli space.Comment: 25 pages, submitted to the Proceedings of the Abel Symposium 201
Geometric invariant theory of syzygies, with applications to moduli spaces
We define syzygy points of projective schemes, and introduce a program of
studying their GIT stability. Then we describe two cases where we have managed
to make some progress in this program, that of polarized K3 surfaces of odd
genus, and of genus six canonical curves. Applications of our results include
effectivity statements for divisor classes on the moduli space of odd genus K3
surfaces, and a new construction in the Hassett-Keel program for the moduli
space of genus six curves.Comment: v1: 23 pages, submitted to the Proceedings of the Abel Symposium
2017, v2: final version, corrects a sign error and resulting divisor class
calculations on the moduli space of K3 surfaces in Section 5, other minor
changes, In: Christophersen J., Ranestad K. (eds) Geometry of Moduli.
Abelsymposium 2017. Abel Symposia, vol 14. Springer, Cha
On Embeddability of Buses in Point Sets
Set membership of points in the plane can be visualized by connecting
corresponding points via graphical features, like paths, trees, polygons,
ellipses. In this paper we study the \emph{bus embeddability problem} (BEP):
given a set of colored points we ask whether there exists a planar realization
with one horizontal straight-line segment per color, called bus, such that all
points with the same color are connected with vertical line segments to their
bus. We present an ILP and an FPT algorithm for the general problem. For
restricted versions of this problem, such as when the relative order of buses
is predefined, or when a bus must be placed above all its points, we provide
efficient algorithms. We show that another restricted version of the problem
can be solved using 2-stack pushall sorting. On the negative side we prove the
NP-completeness of a special case of BEP.Comment: 19 pages, 9 figures, conference version at GD 201
The Young and Bright Type Ia Supernova ASASSN-14lp: Discovery, Early-Time Observations, First-Light Time, Distance to NGC 4666, and Progenitor Constraints
On 2014 Dec. 9.61, the All-Sky Automated Survey for SuperNovae (ASAS-SN or
"Assassin") discovered ASASSN-14lp just days after first light using a
global array of 14-cm diameter telescopes. ASASSN-14lp went on to become a
bright supernova ( mag), second only to SN 2014J for the year. We
present prediscovery photometry (with a detection less than a day after first
light) and ultraviolet through near-infrared photometric and spectroscopic data
covering the rise and fall of ASASSN-14lp for more than 100 days. We find that
ASASSN-14lp had a broad light curve (), a
-band maximum at , a rise time of days, and moderate host--galaxy extinction (). Using ASASSN-14lp we derive a distance modulus for NGC 4666 of
corresponding to a distance of Mpc.
However, adding ASASSN-14lp to the calibrating sample of Type Ia supernovae
still requires an independent distance to the host galaxy. Finally, using our
early-time photometric and spectroscopic observations, we rule out red giant
secondaries and, assuming a favorable viewing angle and explosion time, any
non-degenerate companion larger than .Comment: 12 pages, 9 figures, 4 tables. Accepted to ApJ. Photometric data
presented in this submission are included as an ancillary file. For a brief
video explaining this paper, see https://www.youtube.com/watch?v=1bOV-Cqs-a
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