6 research outputs found
Rh(I)-Catalyzed Decarbonylation of Diynones via C–C Activation: Orthogonal Synthesis of Conjugated Diynes
Utilization of C–C bond activation as a unique mode of reactivity for constructing C–C bonds provides new strategies for preparing important organic molecules. Development of a Rh(I)-catalyzed C–C activation of diynones to synthesize symmetrical and unsymmetrical conjugated diynes through decarbonylation is reported. This C–C cleavage strategy takes advantage of the innate reactivity of conjugated ynones without relying on any ring strain or auxiliary directing group. This alkynation method also has orthogonal properties compared to typical cross-coupling reactions
Rh(I)-Catalyzed Decarbonylation of Diynones via C–C Activation: Orthogonal Synthesis of Conjugated Diynes
Utilization of C–C bond activation as a unique mode of reactivity for constructing C–C bonds provides new strategies for preparing important organic molecules. Development of a Rh(I)-catalyzed C–C activation of diynones to synthesize symmetrical and unsymmetrical conjugated diynes through decarbonylation is reported. This C–C cleavage strategy takes advantage of the innate reactivity of conjugated ynones without relying on any ring strain or auxiliary directing group. This alkynation method also has orthogonal properties compared to typical cross-coupling reactions
Rh-Catalyzed Decarbonylation of Conjugated ynones via Carbon-Alkyne Bond Activation: Reaction Scope and Mechanistic Exploration via DFT Calculations
In this full article, detailed development of a catalytic decarbonylation of conjugated monoynones to synthesize disubstituted alkynes is described. The reaction scope and limitation has been thoroughly investigated, and a broad range of functional groups including heterocycles were compatible under the catalytic conditions. Mechanistic exploration via DFT calculations has also been executed. Through the computational study, a proposed catalytic mechanism has been carefully evaluated. These efforts are expected to serve as an important exploratory study for developing catalytic alkyne-transfer reactions via carbon-alkyne bond activation.UT AustinCPRINIGMS R01GM109054-01Welch Foundation F 1781Natural Science Foundation of China 21232001Chemistr
Access to Highly Substituted 7‑Azaindoles from 2‑Fluoropyridines via 7‑Azaindoline Intermediates
A versatile
synthesis of 7-azaindoles from substituted 2-fluoropyridines
is described. C3-metalation and 1,4-addition to nitroolefins provide
substituted 2-fluoro-3-(2-nitroethyl)Âpyridines. A facile oxidative
Nef reaction/reductive amination/intramolecular S<sub>N</sub>Ar sequence
furnishes 7-azaindolines. Finally, optional regioselective electrophilic
C5-substitution (e.g., bromination or nitration) and subsequent in
situ oxidation delivers highly functionalized 7-azaindoles in high
overall efficiency