14 research outputs found
First imported case of tick-borne encephalitis in Spain - was it alimentary?
As described by Kerlik, et al, tick-borne encephalitis (TBE) is an emerging infectionin Europe and alimentary transmission is increasingly being reported in some European countries[1,2]. However, this is not the case in Spain where no previous cases have been reported [2,3]. Herein, we describe an imported case of TBE in Spain in a boy who probably acquired the virus by ingestion of contaminated milky products in a trip to Estonia
Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence?
Background: Delayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing onceinfected âpittedâ erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. However,
an increasing number of cases with positive direct antiglobulin test (DAT) haemolysis after AS have been reported.
Methods: All malaria cases seen at Hospital Clinic of Barcelona between 2015 and 2017 were retrospectively
reviewed. Clinical, parasitological and laboratory data from patients treated with intravenous artesunateâspecifcally
looking for delayed haemolysis and DATâwas collected.
Results: Among the 36 severe malaria patients treated with artesunate at the hospital, 10 (27.8%) developed postartesunate delayed haemolysis. Out of these, DAT was performed in six, being positive in four of them (at least 40%).
DAT was positive only for complementâwithout IgGâsuggesting drug-dependent immune-haemolytic anaemia of
the immune-complex type. Three of the four patients were treated with corticosteroids and two also received blood
transfusion, with a complete recovery.
Conclusions: Drug-induced auto-immune phenomena in post-artesunate delayed haemolysis may be underreâ
ported and must be considered. The role of corticosteroids should be reassessed
Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2
Post-splenectomy acute glomerulonephritis due to a chronic infection with Plasmodium falciparum and malariae
A 38-year-old Senegalese man with no previous medical history and living in Spain since 2004 was admitted due to fever, hypotension and edemas. The patient had not traveled to malaria endemic areas for the last 2 years, and 43 days before this episode he underwent an elective splenectomy in order to rule out a hematologic neoplasm due to a 27-cm splenomegaly and pancytopenia
Orientacions sobre la diversitat cultural i la salut
Diversitat cultural; AtenciĂł sanitĂ ria; ImmigraciĂłDiversidad cultural; AtenciĂłn sanitaria; InmigraciĂłnCultural diversity; Health care; ImmigrationEl respecte a la dignitat, a la llibertat i a la igualtat de les persones pot plantejar dubtes a lâhora de desenvolupar determinades prĂ ctiques socials. LâĂ mbit sanitari Ă©s receptor de moltes peticions i fins i tot dâexigĂšncies que els professionals
poden arribar a qĂŒestionar dins la seva responsabilitat i el seu compromĂs social.
Cada vegada amb mĂ©s freqĂŒĂšncia, sâadrecen al ComitĂš Consultiu de BioĂštica
sol·licituds dâorientaciĂł i aclariment respecte de problemes concrets.
La via de la casuĂstica circumstancial no sembla la millor manera dâafrontar els
problemes actuals. Cal dur a terme una reflexiĂł Ă mplia, que permeti comprendre
la situaciĂł i fixar unes lĂnies mestres per abordar els casos concrets. Aquesta Ă©s la
tasca que sâintenta amb aquest document, Ă©s a dir, contribuir a fer el camĂ vers la
comprensiĂł de la diversitat cultural en lâĂ mbit de la salut, ja iniciat per altres grups
institucionals
Skin manifestations in COVID-19: prevalence and relationship with disease severity
Background: Data on the clinical patterns and histopathology of SARS-CoV-2 related skin lesions, as well as on their relationship with the severity of COVID-19 are limited. Methods and Materials: Retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection in a teaching hospital in Barcelona, Spain, from 1 April to 1 May 2020. Clinical, microbiological and therapeutic characteristics, clinicopathological patterns of skin lesions, and direct immunofluorescence and immunohistochemical findings in skin biopsies were analyzed. Results: Fifty-eight out of the 2761 patients (2.1%) either consulting to the emergency room or admitted to the hospital for COVID-19 suspicion during the study period presented COVID-19 related skin lesions. Cutaneous lesions could be categorized into six patterns represented by the acronym "GROUCH": Generalized maculo-papular (20.7%), Grover's disease and other papulo-vesicular eruptions (13.8%), livedo Reticularis (6.9%), Other eruptions (22.4%), Urticarial (6.9%), and CHilblain-like (29.3%). Skin biopsies were performed in 72.4%, including direct immunofluorescence in 71.4% and immunohistochemistry in 28.6%. Patients with chilblain-like lesions exhibited a characteristic histology and were significantly younger and presented lower rates of systemic symptoms, radiological lung infiltrates and analytical abnormalities, and hospital and ICU admission compared to the rest of patients. Conclusion: Cutaneous lesions in patients with COVID-19 appear to be relatively rare and varied. Patients with chilblain-like lesions have a characteristic clinicopathological pattern and a less severe presentation of COVID-19