Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study

Introduction: A growing number of studies link the increase in overweight/ obesity worldwide to exposure to certain environmental chemical pollutants that display obesogenic activity (obesogens). Since exposure to obesogens during the first stages of life has been shown to have a more intense and pronounced effect at lower doses, it is imperative to study their possible effects in childhood. The objective here was to study the association of Bisphenol A (BPA) and 11 BPA analogs in children, using three biological matrices (nails, saliva and urine), and overweight and obesity (n = 160). Methods: In this case–control study, 59 overweight/obese children and 101 controls were included. The measuring of Bisphenols in the matrices was carried out by ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UHPLC-MS/MS). Logistic regression was used to study the association between overweight/obesity and Bisphenol exposure. Results: The results suggested that BPF in nails is associated with overweight/ obesity in children (OR:4.87; p = 0.020). In saliva, however, the highest detected concentrations of BPAF presented an inverse association (OR: 0.06; p = 0.010) with overweight/obesity. No associations of statistical significance were detected between exposure to BPA or its other analogs and overweight/obesity in any of the biological matrices.FEDER-Consejería de Salud y Familias’ of the Junta de Andalucía PE-0250-201

Dimensión educativa de los centros de arte: investigación basada en usuarios del Centro José Guerrero de Granada

Tesis Univ. Granada. Departamento de Didáctica de la Expresión Musical, Plástica y Corporal. Leída el 22 de mayo de 200