2,117 research outputs found

    Viability and performance of demountable composite connectors

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    AbstractMaterial production, and associated carbon emissions, could be reduced by reusing products instead of landfilling or recycling them. Steel beams are well suited to reuse, but are difficult to reuse when connected compositely to concrete slabs using welded studs. A demountable connection would allow composite performance but also permit reuse of both components at end-of-life. Three composite beams, of 2m, 10m and 5m length, are constructed using M20 bolts as demountable shear connectors. The beams are tested in three-, six- and four-point bending, respectively. The former two are loaded to service, unloaded, demounted and reassembled; all three are tested to failure. The results show that all three have higher strengths than predicted using Eurocode 4. The longer specimens have performance similar to previously published comparable welded-connector composite beam results. This suggests that demountable composite beams can be safely used and practically reused, thus reducing carbon emissions

    Modelling the embodied carbon cost of UK domestic building construction: Today to 2050

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    The construction of new domestic properties contributes 2% of UK territorial greenhouse gas (GHG) emissions. The UK government aims to increase construction of new homes in England by almost a third, to 300,000 per year by the mid-2020s, whilst simultaneously reducing emissions in line with its net zero 2050 commitment. In this paper, for the first time, the upfront embodied carbon cost of constructing domestic properties in the UK by 2050 is quantified. A bottom-up analysis modelling seven domestic building typologies was used, with the material use for each based on current UK practice. Possible interventions to reduce the embodied carbon cost are then analysed. The results show that maintaining today's levels of construction will use the remaining 2050 carbon budget apportioned to house building (160 MtCO 2e) by 2036, and cause a substantial increase in domestic floor area per capita. However, construction could reduce and cease entirely by 2035 without reducing today's living floor area per capita (37.5 m 2), resulting in a substantially reduced cumulative embodied carbon of 88 MtCO 2e by 2050. Increasing living floor area per capita to the EU average of 40.5 m 2, can be achieved within the carbon budget and with zero emissions by 2050. In contrast, increasing house building to government targets will result in double the cumulative emissions than the budget allows. A number of carbon reduction interventions were then investigated. It was found that of to 75% embodied carbon savings can be achieved by simultaneously changing the typology share, increasing material efficiency, increasing conversion from non-residential buildings and increasing the use of timber for structural purposes.</p

    Annex 1 - Glossary

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    This glossary defines some specific terms as the Lead Authors intend them to be interpreted in the context of this report

    Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study

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    Introduction and background: A significant proportion of patients with intermediate and high risk squamous cell cancer of the oropharynx (OPSCC) continue to relapse locally despite radical chemoradiotherapy (CRT). The toxicity of the current combination of intensified dose per fraction radiotherapy and platinum based chemotherapy limits further uniform intensification. If a predictive biomarker for outcomes from CRT can be identified during treatment then individualised and adaptive treatment strategies may be employed. Methods/design: The MeRInO study is a prospective observational imaging study of patients with intermediate and high risk, locally advanced OPSCC receiving radical RT or concurrent CRT Patients undergo diffusion weighted MRI prior to treatment (MRI_1) and during the third week of RT (MRI_2). Apparent diffusion coefficient (ADC) measurements will be made on each scan for previously specified target lesions (primary and lymph nodes) and change in ADC calculated. Patients will be followed up and disease status for each target lesion noted. The primary aim of the MeRInO study is to determine the threshold change in ADC from baseline to week 3 of RT that may identify the sub-group of non-responders during treatment. Discussion: The use of DW-MRI as a predictive biomarker during RT for SCC H&#38;N is in its infancy but studies to date have found that response to treatment may indeed be predicted by comparison of DW-MRI carried out before and during treatment. However, previous studies have included all sub-sites and biological sub-types. Establishing ADC thresholds that predict for local failure is an essential step towards using DW-MRI to improve the therapeutic ratio in treating SCC H&#38;N. This would be done most robustly in a specific H&#38;N sub-site and in sub-types with similar biological behaviour. The MeRInO study will help establish these thresholds in OPSCC

    Quality of life in children with primary antibody deficiency.

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    Primary antibody deficiency disorders (PADs) can have an excellent outlook if diagnosed early and treated appropriately, but require lifelong treatment with immunoglobulin replacement. Some carry risks of inflammatory complications even with optimal treatment. Quality of life (QoL) and the psychological impact of PADs has been relatively little studied, particularly in children. The purpose of this study was to evaluate QoL and psychological impact in a large group of children affected by a range of PADs, as well as a group with transient hypogammaglobulinemia of infancy (THI). Both parental and, where appropriate, child ratings, were collected using standardised questionnaires (PedsQL and SDQ). Higher rates of psychological difficulties, particularly emotional and peer-relationship difficulties were found in children with PAD when compared with healthy controls. Quality of life was poorer than in healthy controls, and also worse than in children affected by diabetes mellitus. Variations in QoL and the degree of psychological difficulties were found between specific diagnostic groups, with children affected by THI being amongst those with the lowest scores for QoL. Further studies are needed to corroborate and extend these findings, but this study confirms previous findings that primary antibody deficiency has a significant impact on quality of life and psychological well-being, and additionally suggests that the impact varies according to severity of the underlying condition. For those with significant difficulties psychological intervention at an early stage may be beneficial
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