Hypothesis:soluble Aβ oligomers in association with redox-active metal ions are the optimal generators of reactive oxygen species in Alzheimer's disease

Considerable evidence points to oxidative stress in the brain as an important event in the early stages of Alzheimer's disease (AD). The transition metal ions of Cu, Fe, and Zn are all enriched in the amyloid cores of senile plaques in AD. Those of Cu and Fe are redox active and bind to Aβ in vitro. When bound, they can facilitate the reduction of oxygen to hydrogen peroxide, and of the latter to the hydroxyl radical. This radical is very aggressive and can cause considerable oxidative damage. Recent research favours the involvement of small, soluble oligomers as the aggregating species responsible for Aβ neurotoxicity. We propose that the generation of reactive oxygen species (i.e., hydrogen peroxide and hydroxyl radicals) by these oligomers, in association with redox-active metal ions, is a key molecular mechanism underlying the pathogenesis of AD and some other neurodegenerative disorders

Determining the extent to which simulation can be used to train RAF pilots to fly and fight the Eurofighter Typhoon

This research examines the extent to which simulation can be used to train pilots of the Royal Air Force to fly and fight the Eurofighter Typhoon, and is the culmination of a series of trials over a period of 4 years. The approach was threefold, firstly examining the performance of students trained entirely on the Operational Conversion Unit’s full syllabus in the simulator and then tested against their peers on each of the four phases in live flight, secondly investigating the cultural acceptance levels of the present Typhoon pilots and lastly using lessons learnt to generate and test a syllabus to train Typhoon pilots to Mult Role Combat Ready in 40% of the present time. It was found that increasing the proportion of synthetics from the lowest Live Synthetic Balance (LSB) of 75:25 used on the front-line meets a cultural and resource barrier at 50:50. This did not represent the maximum LSB achievable however with the heavily synthetic Multi-Role Syllabus reaching an LSB of 21:79 with successful completion of the end of course test. Cultural acceptance of the simulator had correlations with the squadron a pilot was assigned to, the manner in which the simulators were programmed for use and the experience level of the pilot. No evidence was found within the sample to suggest age had an effect. Recommendations on minimum proportions of live and synthetic training was mapped for each of the required tasks and comparisons of these were made across complexity levels. Resource savings found by the generating and testing a Multi Role Combat Ready syllabus that recognised and incorporated all the strengths, weaknesses and lessons identified in the previous trials generated a saving of approximately 9 months and 100 Typhoon live flying hours per student, equivalent to approximately 1300 man maintenance hours that could be reinvested into personnel in the form of leave, adventurous training or development

The bending and temperature characteristics of long period gratings written in elliptical core step-index fibre

We describe the characterisation of long period gratings written in elliptical core fibre, which yield a discriminatory sensor for curvature and temperature with a resolution ±0.05m-1 for curvature and ±0.9 °C for temperature

The application of a long period grating sensors to human respiratory plethysmography

A series of nine in-line curvature sensors on a garment are used to monitor the thoracic and abdominal movements of a human during respiration for application to Human Respiratory Plethysmography. These results are used to obtain volumetric tidal changes of the human torso which show agreement with data from a spirometer used simultaneously to recorded the inspired and expired volume at the mouth during both rhythmic and transient breathing patterns. The curvature sensors are based upon long period gratings which are written in a progressive three layered fibre to render them insensitive to refractive index changes. The sensor consists of the long period grating laid upon a carbon fibre ribbon, with this then encapsulated in a low temperature curing silicone rubber. The sensing array is multiplexed and interrogated using a derivative spectroscopy based technique to monitor the response of the LPGs' attenuation bands to curvature. The versatility of this scheme is demonstrated by applying the same garment and sensors to various human body types and sizes. It was also found from statistical analysis of the sensing array data, in conjunction with the measurements taken with a spirometer, that 11 to 12 sensors should be required to obtain an absolute volumetric error of 5%

Research activities arising from the University of Kent

In this paper I describe research activities in the field of optical fiber sensing undertaken by me after leaving the Applied Optics Group at the University of Kent. The main topics covered are long period gratings, neural network based signal processing, plasmonic sensors, and polymer fiber gratings. I also give a summary of my two periods of research at the University of Kent, covering 1985–1988 and 1991–2001

Application of long-period-grating sensors to respiratory plethysmography

A series of in-line curvature sensors on a garment are used to monitor the thoracic and abdominal movements of a human during respiration. These results are used to obtain volumetric tidal changes of the human torso in agreement with a spirometer used simultaneously at the mouth. The curvature sensors are based on long-period gratings (LPGs) written in a progressive three-layered fiber to render the LPGs insensitive to the refractive index external to the fiber. A curvature sensor consists of the fiber long-period grating laid on a carbon fiber ribbon, which is then encapsulated in a low-temperature curing silicone rubber. The sensors have a spectral sensitivity to curvature, dλ/dR from ∼7-nm m to ∼9-nm m. The interrogation technique is borrowed from derivative spectroscopy and monitors the changes in the transmission spectral profile of the LPG's attenuation band due to curvature. The multiplexing of the sensors is achieved by spectrally matching a series of distributed feedback (DFB) lasers to the LPGs. The versatility of this sensing garment is confirmed by it being used on six other human subjects covering a wide range of body mass indices. Just six fully functional sensors are required to obtain a volumetric error of around 6%. © 2007 Society of Photo-Optical Instrumentation Engineers

Embedded progressive-three-layered fiber long-period gratings for respiratory monitoring

A long-period grating (LPG) was written into a progressive three-layered single-mode fiber that was embedded into a flexible platform as a curvature sensor. The spectral location and profile of the LPGs were unaltered after implantation in the platform. The curvature sensitivity was 3.747 nm m with a resolution of ± 1.1 × 10-2 m-1. The bend sensor is intended to be part of a respiratory monitoring system and was tested on a resuscitation training manikin. © 2003 society of Photo-Optical Instrumentation Engineers

A high sensitivity refractometer based upon a long period grating Mach-Zehnder interferometer

A low cost interrogation scheme is demonstrated for a refractometer based on an in-line fiber long period grating (LPG) Mach–Zehnder interferometer. Using this interrogation scheme the minimum detectable change in refractive index of ?n ~ 1.8×10-6 is obtained, which is the highest resolution achieved using a fiber LPG device, and is comparable to precision techniques used in the industry including high performance liquid chromatography and ultraviolet spectroscopy