High-Speed Projects in the United States: Identifying the Elements for Success-Part 1, MTI Report 05-01

For almost half a century, high-speed ground transportation (HSGT) has held the promise of fast, convenient, and environmentally sound travel for distances between 40 and 600 miles. While a number of HSGT systems have been developed and deployed in Asia and Europe, none has come close to being implemented in the United States. Yet this is not for lack of trying. There have been several efforts around the country, most of which have failed, some of which are still in the early stages, and a few of which might come to pass. The goal of this study was to identify lessons learned for successfully developing and implementing high-speed rail (HSR) in the United States. Through a broad literature review, interviews, and three specific case studies—Florida, California, and the Pacific Northwest—this study articulates those lessons and presents themes for future consideration

Design evaluation criteria for commercial STOL transports

Handling qualities criteria and operational performance margins have been determined for the landing phase of commercial short-takeoff-and-landing airplanes. The requirements are the result of a literature survey, analysis of areas found to be inadequately covered by current criteria, and a subsequent piloted simulator investigation of critical criteria requiring substantiation. Three complete simulator models were used, each describing the characteristics of a different high-lift system, the externally blown flap, the augmentor flap, and the internally blown flap. The proposed criteria are presented with substantiating discussions from currently available data or directly from the results of this simulation work where it is applicable

Is the US Population Behaving Healthier?

In the past few decades, some measures of population risk have improved, while others have deteriorated. Understanding the health of the population requires integrating these different trends. We compare the risk factor profile of the population in the early 1970s with that of the population in the early 2000s and consider the impact of a continuation of recent trends. Despite substantial increases in obesity in the past three decades, the overall population risk profile is healthier now than it was formerly. For the population aged 25-74, the 10 year probability of death fell from 9.8 percent in 1971-75 to 8.4 percent in 1999-2002. Among the population aged 55-74, the 10 year risk of death fell from 25.7 percent to 21.7 percent. The largest contributors to these changes were the reduction in smoking and better control of blood pressure. Increased obesity increased risk, but not by as large a quantitative amount. In the future, however, increased obesity may play a larger role than continued reductions in smoking. We estimate that a continuation of trends over the past three decades to the next three decades might offset about a third of the behavioral improvements witnessed in recent years.

As-built design specification for LACIE phase 3 automatic status and tracking system

There are no author-identified significant results in this report

Developing Interdisciplinary Partnerships Based on Cognitive Learning Styles

The partnership strategy was for both students and faculty to better communicate and work in cross disciplinary projects by knowing how differing cognitive learning styles impact work quality

Relationship between adiposity and admixture in African-American and Hispanic-American women.

ObjectiveThe objective of this study was to investigate whether differences in admixture in African-American (AFA) and Hispanic-American (HA) adult women are associated with adiposity and adipose distribution.DesignThe proportion of European, sub-Saharan African and Amerindian admixture was estimated for AFA and HA women in the Women's Heath Initiative using 92 ancestry informative markers. Analyses assessed the relationship between admixture and adiposity indices.SubjectsThe subjects included 11 712 AFA and 5088 HA self-identified post-menopausal women.ResultsThere was a significant positive association between body mass index (BMI) and African admixture when BMI was considered as a continuous variable, and age, education, physical activity, parity, family income and smoking were included covariates (P<10(-4)). A dichotomous model (upper and lower BMI quartiles) showed that African admixture was associated with a high odds ratio (OR=3.27 (for 100% admixture compared with 0% admixture), 95% confidence interval 2.08-5.15). For HA, there was no association between BMI and admixture. In contrast, when waist-to-hip ratio (WHR) was used as a measure of adipose distribution, there was no significant association between WHR and admixture in AFA but there was a strong association in HA (P<10(-4); OR Amerindian admixture=5.93, confidence interval=3.52-9.97).ConclusionThese studies show that: (1) African admixture is associated with BMI in AFA women; (2) Amerindian admixture is associated with WHR but not BMI in HA women; and (3) it may be important to consider different measurements of adiposity and adipose distribution in different ethnic population groups

Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond.

Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells. Here we report a facile system for genome editing in non-transformed macrophages by differentiating ER-Hoxb8 myeloid progenitors from Cas9-expressing transgenic mice. These conditionally immortalized macrophages (CIMs) retain characteristics of primary macrophages derived from the bone marrow yet allow for easy genetic manipulation and a virtually unlimited supply of cells. We demonstrate the utility of this system for dissection of host genetics during intracellular bacterial infection using two important human pathogens: Listeria monocytogenes and Mycobacterium tuberculosis

Categorical Data Analysis on the Use of Antimalarial Drugs on Adult Patients in Yenagoa, Bayelsa State

Anti-malarial drugs are drugs used to treat or prevent malaria in endemic countries. The purpose of this work was aimed at analyzing the use of anti-malarial drugs on adult patients in Federal Medical Centre (FMC), Yenagoa. A systematic random sampling technique was used to select the sample size of 5230 patients’ folder from available records which consisted of 2458 and 2772 male and females respectively. An archival-descriptive research design was used which enabled the study obtained data from General Out Patient Department (GOPD). Data obtained were analyzed by using tables, bar chart, pie chart and chi-square statistical test. Four null hypotheses were tested at 0.05 alpha level of significance which HO1 was retained, while HO2, HO3, and HO4 were rejected at df3 of critical X2 value of 7.815. Result from the analysis of sex ratio gave male-female ratio was 89:100, indicating more females were treated however the difference was not significant. It was tested and observed that four different categories of anti-malarial drugs were used in the year 2012 and all the used anti-malarial drugs showed side effects. Meanwhile, Artemisinin Combination Therapy was most frequently used in the health facilities. Based on the findings, conclusions were drawn  and recommendation were made that government, World Health Organization and other non-governmental agencies should  hasten the development of malaria vaccine and ACTs should be available at all times for the treatment of adult patients with malaria. Keywords: categorical data, antimalarial drugs, general out-patient department (GOPD), malaria