Extreme Nonlinear Optics in a Femtosecond Enhancement Cavity

Intrinsic to the process of high-order harmonic generation is the creation of plasma and the resulting spatiotemporal distortions of the driving laser pulse. Inside a high finesse cavity where the driver pulse and gas medium are reused, this can lead to optical bistability of the cavity-plasma system, accumulated self-phase modulation of the intracavity pulse, and coupling to higher order cavity modes. We present an experimental and theoretical study of these effects and discuss their implications for power scaling of intracavity high-order harmonic generation and extreme ultraviolet frequency combs

Leadership and Sexuality: Power, Principles and Processes

Although both leadership and sexuality are important and heavily researched topics, there is little work that addresses the interaction of the two areas. Leadership and Sexuality: Power, Principles, and Processes is a scholarly synthesis of leadership principles with issues related to sexuality and sexual policy-making. The authors\u27 multi-disciplinary analysis of the topic examines sexuality in the context of many different kinds of leadership, exploring both the good and the bad aspects of leadership and sexuality. These integrated topics are examined through three broad areas of study. The first involves individuals who become leaders in sexual domains by advancing new views of human sexuality. The second involves problems that leaders of businesses and other institutions must address as a result of issues related to human sexuality, including sexual harassment and sexually-based discrimination in the workplace. The third area involves understanding how being a leader influences sexual desire and sexual attraction, and may impact the course of workplace romance and the expression of sexuality.Written to be accessible to both laypeople and scholars, this book will appeal to academics and scientists interested in human sexuality as well as many related disciplines, including psychology, sociology, leadership studies, heroism science, political science, religion, and economics.https://scholarship.richmond.edu/bookshelf/1309/thumbnail.jp

Pressures to Comply or Defy: How Social Values Influence Perceptions of Healthcare Workers as Villains

During the Covid-19 pandemic, politicians, the media, and the public labeled frontline workers as heroes. The goal of this article is to examine how certain aspects of the Covid-19 pandemic—such as the nature of the Covid-19 virus, coupled with insufficient governmental and institutional responses—created a situation where it became possible for people to characterize healthcare workers as villains. This approach to medical professionals is rather novel in heroism studies and social sciences. A qualitative review of available data sources provided evidence that frontline healthcare workers were perceived negatively. Experiencing a lack of cooperation from patients and their families, healthcare personnel were forced to deal with institutional constraints that exacerbated these conflicts. Variables that could influence being villainized included the social value orientation and political persuasion of perceivers, as well as structural factors related to the transmission of effective and accurate information, including biased mass media presentations and genuine uncertainty from scientific sources

The Dynamic Negotiated Exchange Model of Heroism and Heroic Leadership: Lessons From the COVID-19 Pandemic

This article proposes a new model of heroism and heroic leadership that conceptualizes the exchange relationship between heroic leaders and the recipients of heroic action as dynamic and negotiated. Previous exchange models portraying heroic leadership exchange as static and passive are shown to be inadequate under conditions of major societal upheaval. Underlying the Dynamic Negotiated Exchange (DNE) model is the idea that equitable hero–recipient exchange during times of societal crises becomes strained and subject to negotiated revision. The terms of the negotiation are first manifest in media dialogue and then translate to individual or structural reforms offering more equitable exchange outcomes. To illustrate our model, we use examples from the COVID-19 pandemic, during which dynamic negotiated exchanges are demonstrated in phenomena such as the Great Resignation and the Great Upgrade

The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA

Background: Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes a T3SS required for intracellular survival of the pathogen. Genes in SPI-2 include apparatus components, secreted effectors and chaperones that bind to secreted cargo to coordinate their release from the bacterial cell. Although the effector repertoire secreted by the SPI-2 T3SS is large, only three virulence-associated chaperones have been characterized. Results: Here we report that SscA is the chaperone for the SseC translocon component. We show that SscA and SseC interact in bacterial cells and that deletion of sscA results in a loss of SseC secretion, which compromises intracellular replication and leads to a loss of competitive fitness in mice. Conclusions: This work completes the characterization of the chaperone complement within SPI-2 and identifies SscA as the chaperone for the SseC translocon