The Greenland Ice Sheet Project 2 Depth-age Scale: Methods and Results

The Greenland Ice Sheet Project 2 (GISP2) depth-age scale is presented based on a multiparameter continuous count approach, to a depth of 2800 m, using a systematic combination of parameters that have never been used to this extent before. The ice at 2800 m is dated at 110,000 years B.P. with an estimated error ranging from 1 to 10% in the top 2500 m of the core and averaging 20% between 2500 and 2800 m. Parameters used to date the core include visual stratigraphy, oxygen isotopic ratios of the ice, electrical conductivity measurements, laser-light scattering from dust, volcanic signals, and major ion chemistry. GISP2 ages for major climatic events agree with independent ages based on varve chronologies, calibrated radiocarbon dates, and other techniques within the combined uncertainties. Good agreement also is obtained with Greenland Ice Core Project ice core dates and with the SPECMAP marine timescale after correlation through the δ18O of O2. Although the core is deformed below 2800 m and the continuity of the record is unclear, we attempted to date this section of the core on the basis of the laser-light scattering of dust in the ice

Short-wavelength collective modes in a binary hard-sphere mixture

We use hard-sphere generalized hydrodynamic equations to discuss the extended hydrodynamic modes of a binary mixture. The theory presented here is analytic and it provides us with a simple description of the collective excitations of a dense binary mixture at molecular length scales. The behavior we predict is in qualitative agreement with molecular-dynamics results for soft-sphere mixtures. This study provides some insight into the role of compositional disorder in forming glassy configurations.Comment: Published; withdrawn since already published. Ordering in the archive gives misleading impression of new publicatio

The Ay Problem for p-3He Elastic Scattering

We present evidence that numerically accurate quantum calculations employing modern internucleon forces do not reproduce the proton analyzing power, A_y, for p-3He elastic scattering at low energies. These calculations underpredict new measured analyzing powers by approximately 30% at E_{c.m.} = 1.20 MeV and by 40% at E_{c.m.} = 1.69 MeV, an effect analogous to a well-known problem in p-d and n-d scattering. The calculations are performed using the complex Kohn variational principle and the (correlated) Hyperspherical Harmonics technique with full treatment of the Coulomb force. The inclusion of the three-nucleon interaction does not improve the agreement with the experimental data.Comment: Latex file, 4 pages, 2 figures, to be published on Phys. Rev. Let

A search for new particles in proton‐nucleus collisions at 400 GeV/c

We report preliminary results from a search for new particles produced in proton‐nucleus collisions at 400 GeV/c. A double‐arm spectrometer is used to detect two‐body final states where each spectrometer arm has the capability of uniquely identifying Π±, K±, p, ?, μ±, and ϕ. The Jψ is measured in the μ+μ− mode.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87398/2/30_1.pd

Effects of thermal fluctuation and the receptor-receptor interaction in bacterial chemotactic signalling and adaptation

Bacterial chemotaxis is controlled by the conformational changes of the receptors, in response to the change of the ambient chemical concentration. In a statistical mechanical approach, the signalling due to the conformational changes is a thermodynamic average quantity, dependent on the temperature and the total energy of the system, including both ligand-receptor interaction and receptor-receptor interaction. This physical theory suggests to biology a new understanding of cooperation in ligand binding and receptor signalling problems. How much experimental support of this approach can be obtained from the currently available data? What are the parameter values? What is the practical information for experiments? Here we make comparisons between the theory and recent experimental results. Although currently comparisons can only be semi-quantitative or qualitative, consistency is clearly shown. The theory also helps to sort a variety of data.Comment: 26 pages, revtex. Journal version. Analysis on another set of data on adaptation time is adde

SLAC's polarized electron source laser system for the E-158 parity violation experiment

SLAC E158 is an experiment to make the first measurement of parity violation in Moller scattering. The left-right cross-section asymmetry in the elastic scattering of a 45-GeV polarized electron beam off unpolarized electrons in a liquid hydrogen target will be measured to an accuracy of better than 10-8, with the expected Standard Model asymmetry being approximately 10-7. An intense circularly polarized laser beam for the polarized electron source is required with the ability to quickly switch between left and right polarization states with minimal left-right asymmetries in the parameters of the electron beam. This laser beam is produced by a unique SLAC-designed, flash-lamp pumped, Ti:Sapphire laser. We present this laser system design and initial results from recent commissioning runs

Adolescents with Learning Disabilities

The subjective experiences of adolescents with learning disabilities (LD) were compared to those of their low-achieving and normally achieving peers. Three groups of juniors and seniors from one suburban high school district, 18 students with learning disabilities (15 males, 3 females), 17 low-achieving students (12 males, 5 females), and 20 average-achieving students (12 males, 8 females), were given electronic pagers and booklets for 1 week. They were signaled every 40 minutes during school hours, and every 2 hours after school. As soon as possible after receiving a signal, they responded to questions in their booklets. The questions provided subjective measures on levels of affect, activation, cognitive efficiency, self-esteem, motivation, and feedback from others. The students with learning disabilities reported feeling more positive and active than either of the other groups during school hours, while after school there were no differences on any of the subjective measures for the three groups. Specific LD school practices are highlighted for their probable impact on the heightened affect and activation of the students with learning disabilities.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68706/2/10.1177_002221949302600912.pd

Record Drilling Depth Struck in Greenland

On July 1, 1993, after 5 years of drilling, the Greenland Ice Sheet Project (GISP2) penetrated several meters of silty ice and reached bedrock at a depth of 3053.4 m. It then penetrated 1.5 m into the bedrock, producing the deepest ice core ever recovered (Figure 1). In July 1992, a nearby European ice coring effort, the Greenland Ice Core Project (GRIP), reached an ice depth of 3028.8 m, providing more than 250,000 years of record. Comparisons between these ice core records have already demonstrated the remarkable reproducibility of the upper ∼90% of the records unparalleled view of climatic and environmental change

Bell State Preparation using Pulsed Non-Degenerate Two-Photon Entanglement

We report a novel Bell state preparation experiment. High-purity Bell states are prepared by using femtosecond pulse pumped \emph{nondegenerate} collinear spontaneous parametric down-conversion. The use of femtosecond pump pulse {\em does not} result in reduction of quantum interference visibility in our scheme in which post-selection of amplitudes and other traditional mechanisms, such as, using thin nonlinear crystals or narrow-band spectral filters are not used. Another distinct feature of this scheme is that the pump, the signal, and the idler wavelengths are all distinguishable, which is very useful for quantum communications.Comment: 4 pages, submitted to PR

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

BACKGROUND: Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to develop more effective anti-cancer drugs in dogs. SG2000 (SJG-136) is a sequence selective DNA minor groove cross-linking agent. Based on its in vitro potency, the spectrum of in vivo and clinical activity against human tumours, and its tolerability in human patients, SG2000 has potential as a novel therapeutic against spontaneously occurring canine malignancies. RESULTS: In vitro cytotoxicity was assessed using SRB and MTT assays, and in vivo activity was assessed using canine tumour xenografts. DNA interstrand cross-linking (ICL) was determined using a modification of the single cell gel electrophoresis (comet) assay. Effects on cell cycle distribution were assessed by flow cytometry and measurement of γ-H2AX by immunofluorescence and immunohistochemistry. SG2000 had a multi-log differential cytotoxic profile against a panel of 12 canine tumour cell lines representing a range of common tumour types in dogs. In the CMeC-1 melanoma cell line, DNA ICLs increased linearly with dose following a 1 h treatment. Peak ICL was achieved within 1 h and no removal was observed over 48 h. A relationship between DNA ICL formation and cytotoxicity was observed across cell lines. The formation of γ-H2AX foci was slow, becoming evident after 4 h and reaching a peak at 24 h. SG2000 exhibited significant anti-tumour activity against two canine melanoma tumour models in vivo. Anti-tumour activity was observed at 0.15 and 0.3 mg/kg given i.v. either once, or weekly x 3. Dose-dependent DNA ICL was observed in tumours (and to a lower level in peripheral blood mononuclear cells) at 2 h and persisted at 24 h. ICL increased following the second and third doses in a repeated dose schedule. At 24 h, dose dependent γ-H2AX foci were more numerous than at 2 h, and greater in tumours than in peripheral blood mononuclear cells. SG2000-induced H2AX phosphorylation measured by immunohistochemistry showed good correspondence, but less sensitivity, than measurement of foci. CONCLUSIONS: SG2000 displayed potent activity in vitro against canine cancer cell lines as a result of the formation and persistence of DNA ICLs. SG2000 also had significant in vivo antitumour activity against canine melanoma xenografts, and the comet and γ-H2AX foci methods were relevant pharmacodynamic assays. The clinical testing of SG2000 against spontaneous canine cancer is warranted. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-015-0534-2) contains supplementary material, which is available to authorized users