52 research outputs found
Correction: Treatment of achalasia: the short-term response to botulinum toxin injection seems to be independent of any kind of pretreatment
Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design
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Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl− Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl− Currents
Helicobacter pylori eradication does not influence gastroesophageal reflux disease: a prospective, parallel, randomized, open-label, controlled trial
Mechanisms of excitatory actions of neurotensin on canine small intestinal circular muscle in vivo and in vitro.
We have shown previously that close intra-arterial injections of neurotensin in vivo inhibited phasic activity induced by field stimulation of the canine small intestine during anaesthesia but had little effect during quiescence. In contrast, in vitro in the present study, full thickness strips of the muscularis externa cut in the circular axis responded to the lowest effective neurotensin concentrations (10(-12) to 10(-9) M) with an increase in frequency and amplitude of spontaneous contractions; as the concentration was increased from 10(-8) to 10(-7) M, neurotensin inhibited spontaneous activity. A small tonic contraction also occurred; it was maximal at 10(-7) M. Since sufficient tetrodotoxin to block field-stimulated nerve responses did not significantly reduce any of these responses in vitro, the neurotensin responses in vitro did not appear to involve actions on nerves. Indomethacin did not alter the excitatory response to 10(-11) M neurotensin but 5,8,11,14-eicosatetraynoic acid inhibited the excitatory response in a reversible fashion, without altering the response to acetylcholine. Thus excitation in vitro may require the release of excitatory metabolites of arachidonic acid via the lipoxygenase pathway. The neurotensin response in vivo was further studied by evaluating its actions against repetitive submaximal contractions induced by intra-arterial injections of acetylcholine given every minute. Doses that produced a short inhibition of the field-stimulated activity (10(-11) to 10(-10) mol intra-arterially) did not produce inhibition but 10(-10) mol significantly increased the response to acetylcholine. Higher doses (10(-9) mol) produced a significant inhibition of the first subsequent acetylcholine dose but no enhancement of later doses.(ABSTRACT TRUNCATED AT 250 WORDS
Hypopharyngeale und ösophageale Defekte nach anteriorer Instrumentierung der HWS - seltene Komplikation und rekonstruktive Herausforderung
Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography
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