61 research outputs found
The 14C, 13C, and 15N syntheses of a potent VEGFR-2 kinase inhibitor, Brivanib, and its prodrug, Brivanib Alaninate
No full textComparisons of Hydroperoxide Isomerase and Monooxygenase Activities of Cytochrome P450 for Conversions of Allylic Hydroperoxides and Alcohols to Epoxyalcohols and Diols: Probing Substrate Reorientation in the Active Site †
No full textDirect Carbon Isotope Exchange Through Decarboxylative Carboxylation
No full textA two-step degradation-reconstruction approach to the carbon-14 radiolabeling of alkyl carboxylic acids is presented. Simple activation via redox-active ester formation was followed by nickel-mediated decarboxylative carboxylation to afford a range of complex compounds with ample isotopic incorporations for drug metabolism and pharmacokinetic studies. The practicality and operational simplicity of the protocol was demonstrated by its use in an industrial carbon-14 radiolabeling setting
Asymmetric syntheses by Grignard compounds prepared in optically active solvents: Part I. Optically active monofunctional ethers
No full text
Biosynthesis of juvenile hormone in thececropia moth. labelling pattern from 1-[14C]-propionate through degradation to single carbon atom derivatives
No full text
Beziehungen zwischen Respiration und innerer Atmosph�re bei CO2-empfindlichen Kernobstsorten
No full text- …
