An evolutionary complex systems decision-support tool for the management of operations

Purpose - The purpose of this is to add both to the development of complex systems thinking in the subject area of operations and production management and to the limited number of applications of computational models and simulations from the science of complex systems. The latter potentially offer helpful decision-support tools for operations and production managers. Design/methodology/approach - A mechanical engineering firm was used as a case study where a combined qualitative and quantitative methodological approach was employed to extract the required data from four senior managers. Company performance measures as well as firm technologies, practices and policies, and their relation and interaction with one another, were elicited. The data were subjected to an evolutionary complex systems (ECS) model resulting in a series of simulations. Findings - The findings highlighted the effects of the diversity in management decision making on the firm's evolutionary trajectory. The CEO appeared to have the most balanced view of the firm, closely followed by the marketing and research and development managers. The manufacturing manager's responses led to the most extreme evolutionary trajectory where the integrity of the entire firm came into question particularly when considering how employees were utilised. Research limitations/implications - By drawing directly from the opinions and views of managers, rather than from logical "if-then" rules and averaged mathematical representations of agents that characterise agent-based and other self-organisational models, this work builds on previous applications by capturing a micro-level description of diversity that has been problematical both in theory and application. Practical implications - This approach can be used as a decision-support tool for operations and other managers providing a forum with which to explore: the strengths, weaknesses and consequences of different decision-making capacities within the firm; the introduction of new manufacturing technologies, practices and policies; and the different evolutionary trajectories that a firm can take. Originality/value - With the inclusion of "micro-diversity", ECS modelling moves beyond the self-organisational models that populate the literature but has not as yet produced a great many practical simulation results. This work is a step in that direction

Safety of localizing epilepsy monitoring intracranial electroencephalograph electrodes using MRI: radiofrequency-induced heating

Purpose: To investigate heating during postimplantation localization of intracranial electroencephalograph (EEG) electrodes by MRI. Materials and Methods: A phantom patient with a realistic arrangement of electrodes was used to simulate tissue heating during MRI. Measurements were performed using 1.5 Tesla (T) and 3T MRI scanners, using head- and body-transmit RF-coils. Two electrode-lead configurations were assessed: a standard condition with external electrode-leads physically separated and a fault condition with all lead terminations electrically shorted. Results: Using a head-transmit-receive coil and a 2.4 W/kg head-average specific absorption rate (SAR) sequence, at 1.5T the maximum temperature change remained within safe limits (<1°C). Under standard conditions, we observed greater heating (2.0°C) at 3T on one system and similar heating (<1°C) on a second, compared with the 1.5T system. In all cases these temperature maxima occurred at the grid electrode. In the fault condition, larger temperature increases were observed at both field strengths, particularly for the depth electrodes. Conversely, with a body-transmit coil at 3T significant heating (+6.4°C) was observed (same sequence, 1.2/0.5 W/kg head/body-average) at the grid electrode under standard conditions, substantially exceeding safe limits. These temperature increases neglect perfusion, a major source of heat dissipation in vivo. Conclusion: MRI for intracranial electrode localization can be performed safely at both 1.5T and 3T provided a head-transmit coil is used, electrode leads are separated, and scanner-reported SARs are limited as determined in advance for specific scanner models, RF coils and implant arrangements. Neglecting these restrictions may result in tissue injury

Feasibility of simultaneous intracranial EEG-fMRI in humans: a safety study

In epilepsy patients who have electrodes implanted in their brains as part of their pre-surgical assessment, simultaneous intracranial EEG and fMRI (icEEG-fMRI) may provide important localising information and improve understanding of the underlying neuropathology. However, patient safety during icEEG-fMRI has not been addressed. Here the potential health hazards associated with icEEG-fMRI were evaluated theoretically and the main risks identified as: mechanical forces on electrodes from transient magnetic effects, tissue heating due to interaction with the pulsed RF fields and tissue stimulation due to interactions with the switched magnetic gradient fields. These potential hazards were examined experimentally in vitro on a Siemens 3 T Trio, 1.5 T Avanto and a GE 3 T Signa Excite scanner using a Brain Products MR compatible EEG system. No electrode flexion was observed. Temperature measurements demonstrated that heating well above guideline limits can occur. However heating could be kept within safe limits (< 1.0 °C) by using a head transmit RF coil, ensuring EEG cable placement to exit the RF coil along its central z-axis, using specific EEG cable lengths and limiting MRI sequence specific absorption rates (SARs). We found that the risk of tissue damage due to RF-induced heating is low provided implant and scanner specific SAR limits are observed with a safety margin used to account for uncertainties (e.g. in scanner-reported SAR). The observed scanner gradient switching induced current (0.08 mA) and charge density (0.2 μC/cm2) were well within safety limits (0.5 mA and 30 μC/cm2, respectively). Site-specific testing and a conservative approach to safety are required to avoid the risk of adverse events

Dendritic cells and the immune response to Neisseria meningitis.

The human specific pathogen Neisseria meningitidis is a major cause of bacterial sepsis and meningitis. Effective vaccines have been developed against group A and C strains, but as yet there is no suitable vaccine available for group B N. meningitidis. The activation of Dendritic Cells (DCs) is fundamental to the initiation of an immune response. Microorganisms and microbial products induce DC maturation, including expression of co-stimulatory molecules, HLA molecules, chemokine receptors and cytokines. Maturation and migration of DCs to secondary lymphoid organs is required for the optimal induction of T-lymphocyte responses. This study investigated the importance of lipopolysaccharide (LPS) in the human pathogen N. meningitidis for DC maturation, migration and activation of T cells. DCs activated with wild type N. meningitidis increased expression of co-stimulatory molecules and HLA-DR, and produced high levels of cytokines (TNFalpha and IL-12). Expression of the chemokine receptor CCR7 was increased and DCs migrated in response to the chemokine MIPS? and showed enhanced migration through an endothelial monolayer. In co-culture experiments, T cell proliferation was enhanced by DCs that had been activated with wild type bacteria. In addition, T cell IFNgamma production was increased and IL-4/IL-13 decreased compared to controls, this is consistent with Thl differentiation. In contrast, although DCs activated by the LPS deficient isogenic mutant IpxA- increased expression of co-stimulatory molecules and HLA-DR, they produced less cytokines (TNFalpha and IL-1) than DCs stimulated with wild type bacteria and little or no IL-12. In addition, they did not increase expression of CCR7 or migrate in the presence of MIP3. DCs stimulated with IpxA- were able to activate T cells to proliferate but did not induce Thl differentiation. TLR4 has been shown to be important for responses to LPS but the Asp299Gly polymorphism described in humans was found not to affect monocyte responses to wild type N. meningitidis. These findings have important implications for vaccine design to group B N. meningitidis and suggest that in vitro responses to DCs may be used as a surrogate for in vivo immunisation experiments to test vaccine efficacy

Functional MRI with active, fully implanted, deep brain stimulation systems: Safety and experimental confounds

We investigated safety issues and potential experimental confounds when performing functional magnetic resonance imaging (fMRI) investigations in human subjects with fully implanted, active, deep brain stimulation (DBS) systems. Measurements of temperature and induced voltage were performed in an in vitro arrangement simulating bilateral DBS during magnetic resonance imaging (MRI) using head transmit coils in both 1.5 and 3.0 T MRI systems. For MRI sequences typical of an fMRI study with coil-averaged specific absorption rates (SARs) less than 0.4 W/kg, no MRI-induced temperature change greater than the measurement sensitivity (0.1 °C) was detected at 1.5 T, and at 3 T temperature elevations were less than 0.5 °C, i.e. within safe limits. For the purposes of demonstration, MRI pulse sequences with SARs of 1.45 W/kg and 2.34 W/kg (at 1.5 T and 3 T, respectively) were prescribed and elicited temperature increases (> 1 °C) greater than those considered safe for human subjects. Temperature increases were independent of the presence or absence of active stimulator pulsing. At both field strengths during echo planar MRI, the perturbations of DBS equipment performance were sufficiently slight, and temperature increases sufficiently low to suggest that thermal or electromagnetically mediated experimental confounds to fMRI with DBS are unlikely. We conclude that fMRI studies performed in subjects with subcutaneously implanted DBS units can be both safe and free from DBS-specific experimental confounds. Furthermore, fMRI in subjects with fully implanted rather than externalised DBS stimulator units may offer a significant safety advantage. Further studies are required to determine the safety of MRI with DBS for other MRI systems, transmit coil configurations and DBS arrangements

Animal Agriculture in South Carolina

Livestock Production/Industries,

Dependence of the Superconducting Transition Temperature of MgB2 on Pressure to 20 GPa

The dependence of Tc on nearly hydrostatic pressure has been measured for an isotopically pure (11B) MgB2 sample in a helium-loaded diamond-anvil-cell to nearly 20 GPa. Tc decreases monotonically with pressure from 39.1 K at ambient pressure to 20.9 K at 19.2 GPa. The initial dependence is the same as that obtained earlier (dTc/dP = -1.11(2) K/GPa) on the same sample in a He-gas apparatus to 0.7 GPa. The observed pressure dependence Tc(P) to 20 GPa can be readily described in terms of simple lattice stiffening within standard phonon-mediated BCS superconductivity.Comment: 9 pages, 3 figure

Animal Agriculture in South Carolina: A Fact Book

Livestock Production/Industries,

Interaction between lateral sorting in river bends and vertical sorting in dunes

Sediment is sorted in river bends under the influence of gravity that pulls the heavier grains downslope and secondary flow that drags the finer grains upslope. Furthermore, when dunes are present, sediment is also sorted vertically at the dune lee side. However, sorting functions are poorly defined, since the relation to transverse bed slope and the interaction between lateral and vertical sorting is not yet understood for lack of data under controlled conditions. The objective of this study is to describe lateral sorting as a function of transverse bed slope and to gain an understanding of the interaction between lateral and vertical sorting in river bends. To this end, experiments were conducted with a poorly sorted sediment mixture in a rotating annular flume in which secondary flow intensity can be controlled separately from the main flow velocity, and therefore transverse bed slope towards the inner bend and dune dimensions can be systematically varied. Sediment samples were taken along cross‐sections at the surface of dune troughs and dune crests, and over the entire depth at the location of dune crests (bulk samples), which enabled comparison of the relative contribution of vertical sorting by dunes to lateral sorting by the transverse bed slope. The data show that lateral sorting is always the dominant sorting mechanism in bends, and bulk samples showed minor effects of vertical sorting by dunes as long as all grain‐size fractions are mobile. An empirical bend sorting model was fitted that redistributes the available sediment fractions over the cross‐section as a function of transverse bed slope. Comparison with field data showed that the model accurately reproduces spatially‐averaged trends in sorting at the bend apex in single‐thread channels. The bend sorting model therefore provides a better definition of bend sorting with conservation of mass by size fraction and adds to current understanding of bend sorting. The implication for numerical modelling is that bend sorting mechanisms can be modelled independently of dunes, allowing the application of the active layer concept