2,342 research outputs found
Look What They\u27ve Done to My Song Ma - Digital Sampling in the 90\u27s: A Legal Challenge for Tthe Music Industry
Potassium accumulation in interstitial space during epileptiform seizures
The K42 surface efflux from the cat neocortex and rat hippocampus was studied after preloading with K42 from the surface. This K42 efflux increases from two to nine times during or after all electrically or Metrazol-induced seizures and "spontaneous" seizures. The K42 influex does not change during a seizure, so this increased efflux is not due to change in the diffusion constant or water flow from brain. The time course of the efflux is not compatable with the efflux simply idicating increased turnover of potassium from cells. We conclude there is an increase in the concentration of potassium in the interstitial space during seizures. A model is proposed in which this potassium accumulation is an important step in the regenerative, all-or-none-aspect of the initiation of seizures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32795/1/0000168.pd
Ariel - Volume 2 Number 7
Editors
Richard J. Bonanno
Robin A. Edwards
Associate Editors
Steven Ager
Stephen Flynn
Shep Dickman
Tom Williams
Lay-out Editor
Eugenia Miller
Contributing Editors
Michael J. Blecker
W. Cherry Light
James J. Nocon
Lynne Porter
Editors Emeritus
Delvyn C. Case, Jr.
Paul M. Fernhof
Ariel - Volume 2 Number 6
Editors
Richard J. Bonanno
Robin A. Edwards
Associate Editors
Steven Ager
Stephen Flynn
Shep Dickman
Tom Williams
Lay-out Editor
Eugenia Miller
Contributing Editors
Michael J. Blecker
W. Cherry Light
James J. Nocon
Lynne Porter
Editors Emeritus
Delvyn C. Case, Jr.
Paul M. Fernhof
Research to Practice: Barriers to Transition Planning for Parents of Adolescents with Special Health Care Needs
An examination of the transition planning experiences and concerns of family members of young adults with special health care needs
Silicon based substrate with environmental/ thermal barrier layer
A barrier layer for a silicon containing substrate which inhibits the formation of gaseous species of silicon when exposed to a high temperature aqueous environment comprises a barium-strontium alumino silicate
The Cost of Sex: Quantifying Energetic Investment in Gamete Production by Males and Females
The relative energetic investment in reproduction between the sexes forms the basis of sexual selection and life history theories in evolutionary biology. It is often assumed that males invest considerably less in gametes than females, but quantifying the energetic cost of gamete production in both sexes has remained a difficult challenge. For a broad diversity of species (invertebrates, reptiles, amphibians, fishes, birds, and mammals), we compared the cost of gamete production between the sexes in terms of the investment in gonad tissue and the rate of gamete biomass production. Investment in gonad biomass was nearly proportional to body mass in both sexes, but gamete biomass production rate was approximately two to four orders of magnitude higher in females. In both males and females, gamete biomass production rate increased with organism mass as a power law, much like individual metabolic rate. This suggests that whole-organism energetics may act as a primary constraint on gamete production among species. Residual variation in sperm production rate was positively correlated with relative testes size. Together, these results suggest that understanding the heterogeneity in rates of gamete production among species requires joint consideration of the effects of gonad mass and metabolism
The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite of excretory-secretory products that have recently been subject to in-depth proteomic analysis. Surprisingly, the most abundant secreted protein of adult Brugia malayi is triose phosphate isomerase (TPI), a glycolytic enzyme usually associated with the cytosol. We now show that while TPI is a prominent target of the antibody response to infection, there is little antibody-mediated inhibition of catalytic activity by polyclonal sera. We generated a panel of twenty-three anti-TPI monoclonal antibodies and found only two were able to block TPI enzymatic activity. Immunisation of jirds with B. malayi TPI, or mice with the homologous protein from the rodent filaria Litomosoides sigmodontis, failed to induce neutralising antibodies or protective immunity. In contrast, passive transfer of neutralising monoclonal antibody to mice prior to implantation with adult B. malayi resulted in 60–70% reductions in microfilarial levels in vivo and both oocyte and microfilarial production by individual adult females. The loss of fecundity was accompanied by reduced IFNγ expression by CD4+ T cells and a higher proportion of macrophages at the site of infection. Thus, enzymatically active TPI plays an important role in the transmission cycle of B. malayi filarial parasites and is identified as a potential target for immunological and pharmacological intervention against filarial infections
The Updated Zwicky Catalog (UZC)
The Zwicky Catalog of galaxies (ZC), with m_Zw<=15.5mag, has been the basis
for the Center for Astrophysics (CfA) redshift surveys. To date, analyses of
the ZC and redshift surveys based on it have relied on heterogeneous sets of
galaxy coordinates and redshifts. Here we correct some of the inadequacies of
previous catalogs by providing: (1) coordinates with <~2 arcsec errors for all
of the Nuzc catalog galaxies, (2) homogeneously estimated redshifts for the
majority (98%) of the data taken at the CfA (14,632 spectra), and (3) an
estimate of the remaining "blunder" rate for both the CfA redshifts and for
those compiled from the literature. For the reanalyzed CfA data we include a
calibrated, uniformly determined error and an indication of the presence of
emission lines in each spectrum. We provide redshifts for 7,257 galaxies in the
CfA2 redshift survey not previously published; for another 5,625 CfA redshifts
we list the remeasured or uniformly re-reduced value. Among our new
measurements, Nmul are members of UZC "multiplets" associated with the original
Zwicky catalog position in the coordinate range where the catalog is 98%
complete. These multiplets provide new candidates for examination of tidal
interactions among galaxies. All of the new redshifts correspond to UZC
galaxies with properties recorded in the CfA redshift compilation known as
ZCAT. About 1,000 of our new measurements were motivated either by inadequate
signal-to-noise in the original spectrum or by an ambiguous identification of
the galaxy associated with a ZCAT redshift. The redshift catalog we include
here is ~96% complete to m_Zw<=15.5, and ~98% complete (12,925 galaxies out of
a total of 13,150) for the RA(1950) ranges [20h--4h] and [8h--17h] and
DEC(1950) range [-2.5d--50d]. (abridged)Comment: 34 pp, 7 figs, PASP 1999, 111, 43
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