Magnetic field tuning of polaron losses in Fe doped BaTiO3 single crystals

Artificial tuning of dielectric parameters can result from interface conductivity in polycrystalline materials. In ferroelectric single crystals, it was already shown that ferroelectric domain walls can be the source of such artificial coupling. We show here that low temperature dielectric losses can be tuned by a dc magnetic field. Since such losses were previously ascribed to polaron relaxation we suggest this results from the interaction of hopping polarons with the magnetic field. The fact that this losses alteration has no counterpart on the real part of the dielectric permittivity confirms that no interface is to be involved in this purely dynamical effect. The contribution of mobile charges hopping among Fe related centers was confirmed by ESR spectroscopy showing maximum intensity at ca T\sim40 K.Comment: Submitte

DOES RURAL JOB GROWTH LEAD THE ECONOMY OUT OF RECESSION?

This paper explores the dynamics of rural and non-rural job growth to investigate if job growth starts in rural places, making it one of the leading indicators of economic growth. Empirical results provide mixed evidence. The mixed results of the Granger non-causality tests could be sensitive to the non-rural area definition. The relationship between rural job growth and non-rural job growth is not restricted to post-recession periods. Analysis of Bureau of Labor Statistics data suggests the spillover effects of non-rural growth are larger than the spillover effect of rural growth on non-rural areas. But this positive response of rural growth disappears over time and turns sharply negative. In the long run, "backwash" effects outweigh "spread" effects.Community/Rural/Urban Development,

BILATERAL TRADING AND THE CURSE OF KNOWLEDGE: AN EXPERIMENTAL ECONOMICS STUDY

This research investigates the impact of reporting different kinds of trade information to buyers and sellers in laboratory markets, for which exchange is made through bilateral bargaining. Results suggest that public information may improve the bargaining position of buyers relative to sellers when there is spot delivery. In some cases sellers earn less than in a no information baseline. There is evidence of a curse of knowledge for sellers in our information experiments when quantity traded for the entire market is known. The mandatory price reporting of all trades does not improve the income of sellers.International Relations/Trade,

The Spermatophore in Glossina morsitans morsitans: Insights into Male Contributions to Reproduction.

Male Seminal Fluid Proteins (SFPs) transferred during copulation modulate female reproductive physiology and behavior, impacting sperm storage/use, ovulation, oviposition, and remating receptivity. These capabilities make them ideal targets for developing novel methods of insect disease vector control. Little is known about the nature of SFPs in the viviparous tsetse flies (Diptera: Glossinidae), vectors of Human and Animal African trypanosomiasis. In tsetse, male ejaculate is assembled into a capsule-like spermatophore structure visible post-copulation in the female uterus. We applied high-throughput approaches to uncover the composition of the spermatophore in Glossina morsitans morsitans. We found that both male accessory glands and testes contribute to its formation. The male accessory glands produce a small number of abundant novel proteins with yet unknown functions, in addition to enzyme inhibitors and peptidase regulators. The testes contribute sperm in addition to a diverse array of less abundant proteins associated with binding, oxidoreductase/transferase activities, cytoskeletal and lipid/carbohydrate transporter functions. Proteins encoded by female-biased genes are also found in the spermatophore. About half of the proteins display sequence conservation relative to other Diptera, and low similarity to SFPs from other studied species, possibly reflecting both their fast evolutionary pace and the divergent nature of tsetse's viviparous biology

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions.

Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins. Proteome-wide detection of SUMOylation sites on target proteins typically requires ectopic expression of mutant SUMOs with introduced tryptic sites. Here, we report a method for proteome-wide, site-level detection of endogenous SUMOylation that uses α-lytic protease, WaLP. WaLP digestion of SUMOylated proteins generates peptides containing SUMO-remnant diglycyl-lysine (KGG) at the site of SUMO modification. Using previously developed immuno-affinity isolation of KGG-containing peptides followed by mass spectrometry, we identified 1209 unique endogenous SUMO modification sites. We also demonstrate the impact of proteasome inhibition on ubiquitin and SUMO-modified proteomes using parallel quantitation of ubiquitylated and SUMOylated peptides. This methodological advancement enables determination of endogenous SUMOylated proteins under completely native conditions

Preservation of vestibular evoked myogenic potentials with modified translabyrinthine approach

Vestibular evoked myogenic potentials (VEMPs) represent a relatively recent subject of investigation in regard to diagnosing specific vestibular disorders. Numerous experimental animal models(1-3) and clinical studies(4-9) suggest that VEMPs are a vestibular-colic reflex, the afferent branch of which originates in the acoustic cells of the saccule, conducting signals through the inferior vestibular nerve. These studies have proposed hypotheses based on the possibility of VEMPs originating in the saccule but have provided no definitive proof to that effect

Балансові показники як інструмент стратегічного бухгалтерського обліку та аналізу

In the article it has been grounded the significant meaning of balanced scorecard for strategic goals realization at an enterprise. It has been also analyzed some approaches considered by different scientists concerning the definition of notions “strategic accounting” and “strategic analysis”. The algorithm of strategic goals realization by means of BSC at an enterprise has been suggested by authors and the basic requirements to analytical and accounting information in the given system have been generalized. The study made it possible to find the connection of balanced scorecard as a method of strategic analysis with accounting to be proved with necessity of unified analytical and accounting system application for effectiveness increase at an enterprise based on the balanced scorecard use.Обоснована необходимость внедрения системы сбалансированных показателей для реализации стратегических целей предприятия. Также проанализированы взгляды ученых на определение понятий «стратегический учет» и «стратегический анализ». Авторами предложен алгоритм реализации стратегических целей предприятия при помощи сбалансованной системы показателей и обобщены основе требования к учетно-аналитической информации у данной системе. Исследование дало возможность определить связь сбалансированной системы показателей, как метода стратегического анализа, с бухгалтерским учетом, что подтверждает необходимость применения целостной учетно-аналитической системы для повышения эффективности деятельности предприятия, в основе которой лежит сбалансированная система показателей.Обґрунтовано важливість впровадження системи збалансованих показників для реалізації стратегічних цілей підприємства. Також проаналізовано погляди різних науковців на визначення поняття «стратегічний облік» і «стратегічний аналіз». Запропоновано алгоритм реалізації стратегічних цілей підприємства за допомогою збалансованої системи показників та узагальнено основні вимоги до обліково-аналітичної інформації у даній системі. Дослідження дало змогу виявити зв'язок збалансованої системи показників як методу стратегічного аналізу з бухгалтерським обліком, що підтверджує необхідність застосування єдиної обліково-аналітичної системи для підвищення ефективності діяльності підприємства, в основі якої лежить використання збалансованої системи показників

IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis

On the basis of their biological function, potential genetic candidates for susceptibility to rheumatoid arthritis can be postulated. IFNGR1, encoding the ligand-binding chain of the receptor for interferon gamma, IFNγR1, is one such gene because interferon gamma is involved in the pathogenesis of the disease. In the coding sequence of IFNGR1, two nucleotide positions have been described to be polymorphic in the Japanese population. We therefore investigated the association of those two IFNGR1 single nucleotide polymorphisms with rheumatoid arthritis in a case-control study in a central European population. Surprisingly, however, neither position was polymorphic in the 364 individuals examined, indicating that IFNGR1 does not contribute to susceptibility to rheumatoid arthritis, at least in Caucasians

The role of parafacial neurons in the control of breathing during exercise

Neuronal cell groups residing within the retrotrapezoid nucleus (RTN) and C1 area of the rostral ventrolateral medulla oblongata contribute to the maintenance of resting respiratory activity and arterial blood pressure, and play an important role in the development of cardiorespiratory responses to metabolic challenges (such as hypercapnia and hypoxia). In rats, acute silencing of neurons within the parafacial region which includes the RTN and the rostral aspect of the C1 circuit (pFRTN/C1), transduced to express HM4D (Gi-coupled) receptors, was found to dramatically reduce exercise capacity (by 60%), determined by an intensity controlled treadmill running test. In a model of simulated exercise (electrical stimulation of the sciatic or femoral nerve in urethane anaesthetised spontaneously breathing rats) silencing of the pFRTN/C1 neurons had no effect on cardiovascular changes, but significantly reduced the respiratory response during steady state exercise. These results identify a neuronal cell group in the lower brainstem which is critically important for the development of the respiratory response to exercise and, determines exercise capacity