Risk Factors Analysis of Low Back Pain in Pregnancy

Low back pain (LBP) adalah hal yang umum terjadi pada populasi. Uniknya, pada perempuan, LBP terjadi pertama kali umumnya saat kehamilan. Dilaporkan kurang lebih 60% wanita hamil mengalami LBP dalam berbagai tingkatan. Meskipun frekuensi LBP dalam kehamilan cukup tinggi, data pasti mengenai prevalensi LBP dalam kehamilan masih sedikit. Identifikasi faktor resiko dan efektifitas intervensi yang dapat dilakukan terhadap penderita juga belum banyak dilaporkan. Dalam penelitian ini dilakukan identifikasi mengenai prevalensi, karakteristik, serta faktor risiko LBP pada ibu hamil. Penelitian menggunakan desain potong lintang dilakukan dengan wawancara terstruktur dan pemeriksaan fisik untuk menetapkan diagnosis dan mencari faktor risiko. Faktor risiko yang didapat bermakna secara statistik adalah riwayat LBP sebelumnya, baik saat hamil maupun tidak hamil, pekerjaan berisiko, kurangnya aktifitas fisik, serta kebiasaan berlibur. Setelah dilakukan analisis multivariat, kebiasaan berlibur tidak menjadi faktor risiko signifikan. Adanya pengetahuan mengenai faktor risiko ini diharapkan dapat membantu klinisi untuk menentukan intervensi yang tepat guna mencegah dan mengatasi LBP pada kehamilan

Obstroctuvie Sleep Apnea dalam Kehamilan

Obstructive sleep apnea (OSA) adalah gangguan tidur yang banyak terjadi pada wanita hamil, dengan prevalensi sebesar 0,3 sampai 5% dari semua wanita hamil. OSA terjadi karena penutupan komplit ataupun inkomplit hidung dan faring secara intermiten, dengan obesitas sebagai fakor risiko mayor. Pasien OSA akan mengalami mengantuk, rasa lelah, serta sakit kepala di siang hari. OSA pada wanita hamil berhubungan dengan kejadian hipertensi dalam kehamilan termasuk preeklampsia, kelahiran preterm, dan tingginya kelahiran sesar akibat inertia uteri. Berkurangnya aliran darah plasenta ke janin pada penderita OSA berhubungan dengan luaran janin yang buruk antara lain pertumbuhan janin terhambat, bayi berat lahir rendah, dan penurunan nilai Apgar akibat hipoksia intra uterin. Penurunan berat badan, perbaikan pola hidup, dan perubahan posisi tidur dikatakan efektif memperbaiki gejala OSA pada wanita hamil. Penggunaan CPAP sampai pembedahan merupakan pilihan terapi pada penderita OSA derajat berat

Maternal Obesity Increases Risk for Adverse Maternal Outcome at RSUP Dr. Mohammad Hoesin Palembang

Objective: To find the relationship between level of obesity and adverse maternal outcomes in pregnant women Method: An observational analytic study with a cross sectional design with secondary data from medical record. Subjects were pregnant women who gave birth at RSUP Dr. Mohammad Hoesin Palembang in January 2015-December 2017. Samples were taken by purposive sampling technique. BMIs  were divided into 5 categories based on WHO criteria, normoweight, overweight, obese level I, II, and III. Underweight was excluded from the study.Result: Of 252 research subjects, 94 (37.3%) were subjects with normal BMI, 102 (40.5%) were overweight, 44 (17.5%) were obese level I, 6 (2.4%) were level II, and 6 (2.4%) were level III. The maternal outcome consisted of 135 cases (53.6%) of preeclampsia, 6 cases of gestational diabetes mellitus (2.4%), 41 cases of uterine inertia (16.3%), 56 cases of preterm labor (22.2%), assisted delivery 111 cases (44%), and healthcare associated infections (HAIs) 6 cases (2.4%). Further analysis showed that increased level of maternal obesity is related significantly with preeclampsia, gestational diabetes mellitus, uterine inertia, and assisted delivery.Conclusion: There are statistically significant association between obesity level and the incidence of preeclamsia, gestational diabetes, uterine inertia and assisted delivery.Obesitas Pada Wanita Hamil Meningkatkan Morbiditas Maternal Di RSUP Dr. Mohammad Hoesin PalembangAbstrakTujuan: Untuk menemukan hubungan antara tingkat obesitas dengan luaran maternal pada wanita hamil. Metode: Studi analitik observasional dengan desain potong lintang menggunakan data sekunder rekam medis. Subjek adalah wanita hamil yang melahirkan di RSUP Dr.Mohammad Hoesin Palembang pada Januari 2015 - Desember 2017. Sampel diambil secara purposive sampling. Indeks massa tubuh (IMT) dibagi menjadi 5 sesuai kriteria WHO, yaitu normal, berat badan lebih, obesitas level I, II, dan III. Berat badan kurang diekslusi dari penelitian. Hasil: Subjek penelitian dari 252 orang, 94 (37.3%) subjek dengan IMT normal, 102 (40.5%) subjek berat badan berlebih,  44 (17.5%) obesitas level I,  6 (2.4%) obesitas level II, dan 6 (2.4%) obesitas level III. Luaran  maternal terdiri dari 135 kasus (53.6%) of preeklampsia, 6 kasus diabetes mellitus gestasional,  41 kasus inertia uteri  (16.3%), 56 kasus persalinan preterm (22.2%), 111 kasus (44%) persalinan pervaginam berbantu, dan infeksi luka 6 kasus (2.4%).  Analisis menunjukkan adanya tingkatan obesitas maternal berkaitan secara signifikan dengan kejadian preeklampsia, diabetes mellitus gestasional, inertia uteri, dan persalinan pervaginam berbantu. Kesimpulan: Terdapat hubungan antara tingkat obesitas pada ibu hamil dengan preeklampsia, diabetes mellitus gestasional, dan persalinan pervaginam berbantu. Kata kunci: Indeks Massa Tubuh, Obesitas, Luaran Maternal, Morbiditas

Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis

Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (

The Association between Aromatase Gene Polymorphism Cyp19 Val 80 and Endometriosis Risk

Background: Endometriosis implant has been known to express aromatase enzyme, Cytochrome p450 that catalyzes androgen into estrogen. It causes local estrogen production, leading to increased estrogen level, and subsequently triggers endometriosis lesion. CYP19 gene resided at chromosome 15q21.1 is the biggest component of aromatase coding cytochrome p450 enzyme. Objective: To identify relationship between aromatase gene polymorphism CYP19 Val 80 and the risk of endometriosis. Methods: This is an observational case-control study using frozen DNA sample from women with endometriosis and/ or adenomyosis who had undergone laparotomy/ laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang January-November 2013. Samples were amplified and cut by PCR-FRLP using Rsa1 restriction enzyme. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type).  Data were analyzed by SPSS 21.0 version. Results: PCR-RFLP results for A/A genotype were 20 (21.3%) in endometriosis group and 8 (8.5%) in control group. G/A genotype were 18 (19.1%) in endometriosis group and 22 (23.4%) in control group. G/G genotype were 9 (9.6%) and 17 (18.1%) in endometriosis group and control group, respectively. There was significant increase risk of endometriosis in women carrying genotype A/A to those with genotype G/G with OR 4.722 (p<0.05). Conclusion: Polymorphism on aromatase gene CYP19 Val 80 A/A increases risk of endometriosis

Identification of Lactic Acid Bacteria Isolate From Fermentation Food Bekasam

Bekasam is a local food from South Sumatera Indonesia, which is obtained through fermentation of fish. Previous study has shown that fermented food contained Lactic Acid Bacteria (LAB) bacteria, such as Lactobacillus plantarum, Lactobacillus sp, Pediococus sp and Weissella sp. The study was conducted to identify isolate LAB from bekasam. Bekasam contained fish, rice, and salt with a certain ratio. Further isolation of isolated LAB isolate, then performed PCR for bacterial analysis. Isolate 1 showed alleged bacteria Staphylococcus sp, non pathogen, while isolate 2 leads to Lactobacillus sp. The PCR results show the suitability of the bands formed between the Lactobacillus standard and the isolates.   Keywords: bacteria, lactobacillus, aci

Characteristics of Endometriosis Patients in Dr. Mohammad Hoesin General Hospital on 2018 to 2020

Background. Endometriosis is defined as the presence of endometrial-like tissue outside the uterus. The prevalence of endometriosis is not known with certainty because it is necessary to perform a laparoscopy to confirm the diagnosis of endometriosis and is usually found during examination for other indications. This study aims to explore the characteristics of endometriosis patients at Dr. Mohammad Hoesin General Hospital Palembang. Methods. This research is descriptive observational research. The research data were obtained from the medical records of endometriosis patients treated at Dr. Mohammad Hoesin General Hospital Palembang from 2018 to 2020. Results. Of the 105 sample data studied, the most distribution of endometriosis patients was in the reproductive age group (15-49 years) (99%), menarche 12-14 years (67.6%), the location of endometriosis in the ovaries (58.1%), status indoor workers (99%), marital status (85.7%), fertile (43.8%), and infertile patients (41.9%), the chief complaint of dysmenorrhea (66.7%), stage IV disease (63, 8%), nullipara (60%), surgical management (79%). Conclusion. Most of the characteristics of endometriosis patients were in the reproductive age group (15 – 49 years), menarche 12-14 years, endometriosis location in the ovary, indoor worker status, marital status, infertility, the main complaint of dysmenorrhea, stage IV disease, nullipara, surgical treatment

The Relation Between Prenatal Maternal Stress and Sleep Quality of Pregnant Women in Palembang

Objective: The aim of this research is to know incidence and relationship between prenatal maternal stress and sleep quality in pregnant women in Palembang City. This study also aims to determine the factors that influence prenatal maternal stress.Method: Observational analytic study by collecting questionnaires on October 18 - November 19, 2022 in 6 puskesmas in Palembang City. This study used Pregnancy Stress Rating Scale (PSRS) and Pittsburgh Sleep Quality Index (PSQI), followed by calculating the Prevalence Risk.Results: In this study, the results obtained were that of 56 pregnant women in Palembang City, 57.1% experienced stress (mild stress (51.8%) and moderate stress (5.3%)). There were 39.3% of pregnant women with good sleep quality and 60.7% with poor sleep quality. It was found that there was a significant relationship between prenatal maternal stress and sleep quality of pregnant women (PR=4.350; 95% CI; (1.979 – 9.564; p= 0.000). There was a significant relationship between the age of pregnant women and prenatal maternal stress (PR= 0.323; 95) % CI: (0.168 – 0.612); p=0.000) and a significant relationship between maternal work and prenatal maternal stress (PR= 0.425; 95% CI: (0.198 – 0.913); p = 0.013)Conclusion: 57.1% of pregnant women in Palembang experienced stress and 60.7% have poor sleep quality. There was significant relationship between prenatal maternal stress and sleep quality in pregnant women in Palembang City. Factors that influence prenatal maternal stress, namely age and mother's occupation.Hubungan antara Prenatal Maternal Stress dan Kualitas Tidur Ibu Hamil di Kota PalembangAbstractTujuan: Penelitian ini dilakukan dengan tujuan untuk mengetahui insidensi dan hubungan antara prenatal maternal stress dan kualitas tidur pada ibu hamil di Kota Palembang. Penelitian ini juga bertujuan untuk mengetahui faktor-faktor yang memengaruhi prenatal maternal stress.Metode: Penelitian analitik observasional dengan mengumpulkan kuisioner pada tanggal 18 Oktober - 19 November 2022 di 6 puskesmas di Kota Palembang. Penelitian ini menggunakan Pregnancy Stress Rating Scale (PSRS) dan Pittsburgh Sleep Quality Index (PSQI) yang kemudian dilanjutkan penghitungan Prevalence Risk .Hasil: Pada penelitian ini diperoleh hasil, dari 56 ibu hamil di Kota Palembang sebanyak 57,1% mengalami stres (stres ringan (51,8%) dan stres sedang (5,3%)). Terdapat 39,3% ibu hamil dengan kualitas tidur baik dan 60,7% dengan kualitas tidur buruk. Ditemukan bahwa ada hubungan signifikan antara prenatal maternal stress dan kualitas tidur ibu hamil (PR=4.350; 95% CI; (1.979 – 9.564; p= 0,000). Terdapat hubungan signifikan antara usia ibu hamil dengan prenatal maternal stress (PR= 0,323; 95% CI: (0.168 – 0.612); p=0,000) dan hubungan yang signifikan antara pekerjaan ibu dengan prenatal maternal stress (PR= 0.425; 95% CI: (0.198 – 0.913); p = 0,013)Kesimpulan: Sebanyak 57,1% ibu hamil di kota Palembang mengalami stres dan 60,7% memiliki kualitas tidur buruk. Terdapat hubungan signifikan antara prenatal maternal stress dan kualitas tidur pada ibu hamil di Kota Palembang. Faktor yang mempengaruhi  prenatal maternal stress, yaitu usia dan pekerjaan ibu. Kata kunci: Ibu hamil, Prenatal Maternal Stress, Kualitas Tidu