2 research outputs found
Protective Effect of Fish Oil Supplementation on DNA Damage Induced by Cigarette Smoking
The study examined the influence of fish oil (FO) supplementation on
serum 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG) levels as indicated by
DNA damage markers and total antioxidant capacity (TAC) among male
cigarette smokers. This double-blind, placebo-controlled randomized
study was conducted among healthy cigarette smokers (n=40) who were
part of a larger prospective cohort study. Twenty smokers were randomly
selected to receive FO for 3 months (1 g/day), and another 20 smokers
received a placebo for 3 months; 8-OHdG and TAC levels were measured in
blood samples before and after the intervention. Serum 8-OHdG
significantly decreased (p=0.001) and TAC increased (p<0.001) after
3 months of treatment with FO. Between baseline and endline, the
difference in 8-OHdG significantly correlated with the difference in
TAC among smokers who received FO (r=-0.540, p=0.014). The study
provides evidence that FO supplementation can modify decreased
antioxidants and increased oxidative DNA damage in cigarette smokers
Protective Effect of Fish Oil Supplementation on DNA Damage Induced by Cigarette Smoking
The study examined the influence of fish oil (FO) supplementation on
serum 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels as indicated by
DNA damage markers and total antioxidant capacity (TAC) among male
cigarette smokers. This double-blind, placebo-controlled randomized
study was conducted among healthy cigarette smokers (n=40) who were
part of a larger prospective cohort study. Twenty smokers were randomly
selected to receive FO for 3 months (1 g/day), and another 20 smokers
received a placebo for 3 months; 8-OHdG and TAC levels were measured in
blood samples before and after the intervention. Serum 8-OHdG
significantly decreased (p=0.001) and TAC increased (p<0.001) after
3 months of treatment with FO. Between baseline and endline, the
difference in 8-OHdG significantly correlated with the difference in
TAC among smokers who received FO (r=-0.540, p=0.014). The study
provides evidence that FO supplementation can modify decreased
antioxidants and increased oxidative DNA damage in cigarette smokers