The study examined the influence of fish oil (FO) supplementation on
serum 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG) levels as indicated by
DNA damage markers and total antioxidant capacity (TAC) among male
cigarette smokers. This double-blind, placebo-controlled randomized
study was conducted among healthy cigarette smokers (n=40) who were
part of a larger prospective cohort study. Twenty smokers were randomly
selected to receive FO for 3 months (1 g/day), and another 20 smokers
received a placebo for 3 months; 8-OHdG and TAC levels were measured in
blood samples before and after the intervention. Serum 8-OHdG
significantly decreased (p=0.001) and TAC increased (p<0.001) after
3 months of treatment with FO. Between baseline and endline, the
difference in 8-OHdG significantly correlated with the difference in
TAC among smokers who received FO (r=-0.540, p=0.014). The study
provides evidence that FO supplementation can modify decreased
antioxidants and increased oxidative DNA damage in cigarette smokers