5 research outputs found
The InterLACE study: design, data harmonization and characteristics across 20 studies on women's health
The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE
Associations between adult mental wellbeing and social class in childhood and adulthood.
<p>Associations between adult mental wellbeing and social class in childhood and adulthood.</p
Path analysis coefficients for the associations between father’s social class and adult Warwick-Edinburgh Mental Well-Being scores, mediated through adult SEP.
<p>Path analysis coefficients for the associations between father’s social class and adult Warwick-Edinburgh Mental Well-Being scores, mediated through adult SEP.</p
Path model of father’s social class and Warwick-Edinburgh Mental Wellbeing scores, mediated through adult SEP for the four birth cohort studies.
<p>Path model of father’s social class and Warwick-Edinburgh Mental Wellbeing scores, mediated through adult SEP for the four birth cohort studies.</p
Genetic impacts on DNA methylation help elucidate regulatory genomic processes
Background: Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk.
Results: We report heritability and methylation quantitative trait locus (meQTL) analysis at 724,499 CpGs profiled with the Illumina Infinium MethylationEPIC array in 2,358 blood samples from three UK cohorts. Methylation levels at 34.2% of CpGs are affected by SNPs, and 98% of effects are cis-acting or within 1 Mbp of the tested CpG. Our results are consistent with meQTL analyses based on the former Illumina Infinium HumanMethylation450 array. Both SNPs and CpGs with meQTLs are overrepresented in enhancers, which have improved coverage on this platform compared to previous approaches. Co-localisation analyses across genetic effects on DNA methylation and 56 human traits identify 1,520 co-localisations across 1,325 unique CpGs and 34 phenotypes, including in disease-relevant genes, such as USP1 and DOCK7 (total cholesterol levels), and ICOSLG (inflammatory bowel disease). Enrichment analysis of meQTLs and integration with expression QTLs give insights into mechanisms underlying cis-meQTLs (e.g. through disruption of transcription factor binding sites for CTCF and SMC3), and trans-meQTLs (e.g. through regulating the expression of ACD and SENP7 which can modulate DNA methylation at distal sites).
Conclusions: Our findings improve the characterisation of the mechanisms underlying DNA methylation variability and are informative for prioritisation of GWAS variants for functional follow-ups. The MeQTL EPIC Database and viewer are available online at https://epicmeqtl.kcl.ac.uk.</p