A Call to Integrate Religious Communities Into Practice: The Case of Sikhs

Sikhs, an ethnic and religious minority group in the United States, have seen a significant shift in their social location since 9/11. They have experienced harassment and violence beyond race and ethnicity to the visible markers of the religion (e.g., turbans). In this article, we address how counseling psychology is uniquely positioned to work with Sikhs given these circumstances. We provide an overview of Sikh Americans, including specific experiences that may affect treatment such as race-based traumatic injury, identification as a part of a visible religious minority group, and the impact of historic community-level trauma. We discuss recommendations for practitioners working with Sikhs, recognizing how community-level interventions play an integral role and how institutions may serve as valuable allies and resources for practitioners to help better meet the Sikhs’ psychological needs in a culturally competent manner

Lymphangitic Retroperitoneal Carcinomatosis Occurring From Metastatic Sarcomatoid Chromophobe Renal Cell Carcinoma

AbstractA 45-year-old man with left renal mass underwent nephrectomy to reveal a 20-cm tumor diagnosed as sarcomatoid chromophobe renal cell carcinoma. Lymph node metastasis of chromophobe and sarcomatoid components, disseminated tumor in retroperitoneal fat, lymphatic vessels, and perirenal adipose tissue in lymphangitic carcinomatosis pattern were identified. Chromophobe epithelial cells were positive for epithelial membrane antigen, c-Kit, and cytokeratin 7; sarcomatoid cells were positive for CD10 and smooth muscle antigen with high proliferation index. Chromophobe epithelial cells had loss of heterozygosity in chromosomes 1p and 1q, whereas sarcomatoid cells had loss of heterozygosity in 3p, 1p, and 1q. In conclusion, sarcomatoid chromophobe renal cell carcinoma has aggressive biologic behavior and potential to metastasize in unusual patterns

Cephalosporin-resistant pneumococcal pneumonia: does it, affect outcome?

AbstractStudy Objectives: Penicillin resistance has been reported in various studies to have no impact on the outcome of pneumococcal pneumonia. However, the importance of cephalosporin resistance has not been systematically studied. We conducted an analysis of patients with high-level cephalosporin-resistant Streptococcus pneumoniae pneumonia (H-CRSPP)–Design: Retrospective matched, case–control study. Setting: Two inner-city academic hospitals. Patients: Twenty-six patients with H-CRSPP admitted to the hospital between 1995 and 1999 were identified. Each patient was matched with two controls with cephalosporin-sensitive but oxacillin-resistant pneumococcal pneumonia admitted during the same time period. Matching was done based on pneumonia severity of illness index (PSI) and for other factors.Interventions: None. Measurements and Results: We evaluated a number of outcomes including mortality, length of stay in the hospital, and time to respond to treatment. Patients with H-CRSPP took longer to respond to treatment (6.5±0.9 days vs 4.1±0.7 days, P=0.05) and had a longer length of stay in hospital (15.4±2.2 daysvs 9.2±1.6 days, P=0.02), None of the other outcomes were different between the two groups.Conclusions: Overall, we have found that the presence of cephalosporin resistance does impact the course of pneumococcal pneumonia

Neutral evolution of drug resistant colorectal cancer cell populations is independent of their KRAS status

Emergence of tumor resistance to an anti-cancer therapy directed against a putative target raises several questions including: (1) do mutations in the target/pathway confer resistance? (2) Are these mutations pre-existing? (3) What is the relative fitness of cells with/without the mutation? We addressed these questions in patients with metastatic colorectal cancer (mCRC). We conducted an exhaustive review of published data to establish a median doubling time for CRCs and stained a cohort of CRCs to document mitotic indices. We analyzed published data and our own data to calculate rates of growth (g) and regression (d, decay) of tumors in patients with CRC correlating these results with the detection of circulating MT-KRAS DNA. Additionally we estimated mathematically the caloric burden of such tumors using data on mitotic and apoptotic indices. We conclude outgrowth of cells harboring intrinsic or acquired MT-KRAS cannot explain resistance to anti-EGFR (epidermal growth factor receptor) antibodies. Rates of tumor growth with panitumumab are unaffected by presence/absence of MT-KRAS. While MT-KRAS cells may be resistant to anti-EGFR antibodies, WT-KRAS cells also rapidly bypass this blockade suggesting inherent resistance mechanisms are responsible and a neutral evolution model is most appropriate. Using the above clinical data on tumor doubling times and mitotic and apoptotic indices we estimated the caloric intake required to support tumor growth and suggest it may explain in part cancer-associated cachexia

The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D)

BACKGROUND: To investigate the association of DNA nucleotide excision repair (NER) defects with neurological degeneration, cachexia and cancer, we performed autopsies on 4 adult xeroderma pigmentosum (XP) patients with different clinical features and defects in NER complementation groups XP-A, XP-C or XP-D. RESULTS: The XP-A (XP12BE) and XP-D (XP18BE) patients exhibited progressive neurological deterioration with sensorineural hearing loss. The clinical spectrum encompassed severe cachexia in the XP-A (XP12BE) patient, numerous skin cancers in the XP-A and two XP-C (XP24BE and XP1BE) patients and only few skin cancers in the XP-D patient. Two XP-C patients developed internal neoplasms including glioblastoma in XP24BE and uterine adenocarcinoma in XP1BE. At autopsy, the brains of the 44 yr XP-A and the 45 yr XP-D patients were profoundly atrophic and characterized microscopically by diffuse neuronal loss, myelin pallor and gliosis. Unlike the XP-A patient, the XP-D patient had a thickened calvarium, and the brain showed vacuolization of the neuropil in the cerebrum, cerebellum and brainstem, and patchy Purkinje cell loss. Axonal neuropathy and chronic denervation atrophy of the skeletal muscles were observed in the XP-A patient, but not in the XP-D patient. CONCLUSIONS: These clinical manifestations and autopsy findings indicate advanced involvement of the central and peripheral nervous system. Despite similar defects in DNA repair, different clinicopathological phenotypes are seen in the four cases, and therefore distinct patterns of neurodegeneration characterize XP-D, XP-A and XP-C patients

A STUDY OF CONSUMER\'S WILLINGNESS TO PAY FOR NON-PIRATED SOFTWARE IN INDONESIA

A STUDY OF CONSUMER\'S WILLINGNESS TO PAY FOR NON-PIRATED SOFTWARE IN INDONESIA - Normative Susceptibility, Value Consciousness, Novelty Seeking, Performance risk, Social Risk, Prosecution Risk, Willingness To Pa

A Call to Integrate Religious Communities Into Practice: The Case of Sikhs

Sikhs, an ethnic and religious minority group in the United States, have seen a significant shift in their social location since 9/11. They have experienced harassment and violence beyond race and ethnicity to the visible markers of the religion (e.g., turbans). In this article, we address how counseling psychology is uniquely positioned to work with Sikhs given these circumstances. We provide an overview of Sikh Americans, including specific experiences that may affect treatment such as race-based traumatic injury, identification as a part of a visible religious minority group, and the impact of historic community-level trauma. We discuss recommendations for practitioners working with Sikhs, recognizing how community-level interventions play an integral role and how institutions may serve as valuable allies and resources for practitioners to help better meet the Sikhs’ psychological needs in a culturally competent manner

INHIBITION STEPS IN SULFONAMIDE BACTERIOSTASIS OF ESCHERICHIA COLI

This article does not have an abstract

INACTIVITY OF PTEROYLGLUTAMIC ACID AND LEUCOVORIN IN OVERCOMING SULFONAMIDE GROWTH INHIBITION OF ESCHERICHIA COLI

This article does not have an abstract