Association of Genetics traits with obesity in men: A review on the current knowledge in Iran

Today, obesity is one of the leading causes of death. It also causes other diseases such as diabetes, cardiovascular disease, and various types of cancer. Obesity is a multifactorial disease caused by factors such as genetics and lifestyle. However, scientists imagine that about 40-70% of the disease originates from genetics. In this review, we examined the role of different genes in obesity by examining 30 articles published on the role of genetics in the obesity of Iranian men, according to their BMI, comorbidities and family history. We concluded that most of the research has been done on the FTO, Hind III and S447 genes. We also showed an apparent relationship between these genes and obesity. Finally, according to studies, FTO can be considered as the most important and strongest contributor to obesity

Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function.

BackgroundC1q TNF related protein 3 (CTRP3) is an adipokine secreted from adipose tissue. Previous studies have suggested that CTRP3 improves insulin sensitivity and reduces inflammation. Human studies have evaluated circulating levels of this adipokine in patients with diabetes mellitus (DM), diabetic retinopathy, metabolic syndrome, and coronary artery diseases. However, circulating levels of this adipokine in patients with diabetic nephropathy have not been evaluated. The present study aimed to assess serum levels of CTRP3 in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (T2DM-NP) and its relationship with metabolic and inflammatory markers.MethodsThis cross-sectional study was performed on 55 controls, 54 patients with T2DM, and 55 patients with T2DM-NP. Serum levels of CTRP3, adiponectin, TNF-α, and IL-6 were measured by ELISA technique.ResultsSerum levels of CTRP3 were significantly lower in patients with T2DM (257.61 ± 69.79 ng/mL, p ConclusionDecreased serum levels of CTRP3 in patients with T2DM and diabetic nephropathy and its association with pathologic mechanism in these patients suggested a possible role for CTRP3 in pathogenesis of diabetic nephropathy; nevertheless, further studies are required in this regard