ON A DESIGN FROM PRIMITIVE REPRESENTATIONS OF THE FINITE SIMPLE GROUPS

In this paper we present a design construction from primitive permutation representations of a finite simple group G. The group G acts primitively onthe points and transitively on the blocks of the design. The construction has this property that with some conditions we can obtain t-design for t >=2. We examine our design for fourteen sporadic simple groups. As a result we found a 2-(176,5,4) design with full automorphism group M22

Evaluation of some factors affecting the risk of kidney damage in patients with hypertension

Chronic kidney disease (CKD) is an increasing cause of morbidity and mortality worldwide. Prospective data on risk factors for CKD are few. Hypertension is one of the risk factors for CKD. In the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(GFR), which limits its ability to detect impaired kidney function. Cystatin C and NGAL have recently been proven useful to quantitate CKD. Therefore in this study, we assessed the effect of some risk factors on reduction of estimated glomerular filtration rate (eGFR) in patients with high blood pressure. This study was performed on 42 hypertensive patients and 30 healthy volunteers, both with normal serum creatinine and urea concentration. In this study, we measured serum cystatin C and Plasma NGAL. Serum creatinine and urea levels of the patients were measured after an overnight fasting.  . Estimated glomerular filtration rate (eGFR) was considered as the gold standard method .Serum cystatin C and plasma NGAL were measured using commercially available human ELISA kits. Logistic   regression and T-test were used for statistical analysis. The results of logistic regression showed that among the variables studied, plasma levels of NGAL, age and duration of hypertension were significantly associated with the eGFR<78(P<0.05). Our findings suggest that, increased levels of NGAL, age and duration of hypertension predicts a higher odds of impaired renal functio

Subclinical Hypothyroidism and the Alterations of Lipid Profile as a Cardiovascular Risk Factor

The association between overt hypothyroidism and altered lipid profile is well known, whereas the significance of dyslipidemia in subclinical hypothyroidism (SCH) is still a matter of debate. The aim of the present study was to evaluate the lipid profile in patients with SCH in comparison to controls. Serum lipid parameters of 34 patients with SCH and 34 age- and sex-matched healthy controls were evaluated in our study. TC (198.88 ± 42.90 vs 171.40 ± 26.24 mg/dl, P < 0.01) and LDL-C concentrations (129.04 ± 35.44 vs 106.71 ± 26.21 mg/dl, P < 0.01) as well as ratio of LDL-C/HDL-C (3.51 ± 1.46 vs 2.81 ± 0.80, P < 0.05) were significantly higher in the patients in comparison to the controls, whereas HDL-C and TC/HDL-C ratio remained unaltered. TG concentrations were higher in the patients but this difference did not reach statistical significance (0.063). Correlation analyses revealed a significant correlation of TSH with TC, LDL-C and LDL-C/HDL-C ratio (r=0.351, r=0.345, r=0.340, respectively, P < 0.01) and a borderline correlation with TG (p=0.051). Our findings showed that SCH is associated with some lipid abnormalities suggesting higher risk of cardiovascular disease in these patients which seems to weigh in favor of treatment of patients with SCH

The epidemiology of microbial agents related to patients with multiple sclerosis (MS)

     Multiple Sclerosis (MS) is one of the autoimmune diseases which affects the central nervous system and its etiology has not yet been identified. The disparity between youth and disability in reproductive ages is considered to be of particular importance for this disease and the need for research which illuminates various epidemiological, etiologic, clinical and therapeutic angles of multiple sclerosis is deeply felt. The purpose of this study is to consider the epidemiology of microbial agents related to patients with multiple sclerosis (MS). From 37 patients with multiple sclerosis according to the physician examination and McDonald criteria , serum samples were taken. Until testing, serum samples were stored in a freezer at -70 ° C. Subsequently, viral and bacterial agents were identified using specific primers and PCR method. In this study, the numbers of microbial agents were as the following: 7 retrovirus associated with MS (MRSV), 17 EBV, 8 HSV6, 11 JC virus, 10 CMV, 8 B19, 14Corona virus, 1 Helicobacter pylori, 15 Acinetobacter, 9 Borrelia burgdorferi, and 19 Chlamydia pneumonia. Identification of the relationship between different infectious agents in MS is necessary to prepare feasible data about tracing and treatment of MS related to these microorganisms that may be beneficial to clinicians to select a convenient empirical therapeutic diet in MS related to pathogens at the bedhead and can open up a new path to new therapeutic approaches.

Upper bounds on the uniform spreads of the sporadic simple groups

‎‎A finite group $G$ has uniform spread $k$ if there exists a fixed conjugacy class $C$ of elements in $G$ with the property that‎ ‎for any $k$ nontrivial elements $s_1, s_2,‎ldots‎,s_k$ in $G$ there exists $yin C$ such that $G = langle s_i,yrangle$ for $i=1, 2,‎ldots,k$‎. ‎Further‎, ‎the exact uniform spread of $G$ is the largest $k$ such that $G$ has the uniform spread $k$‎. ‎In this paper we give upper bounds on the exact uniform spreads of thirteen sporadic simple groups‎

Assessment of Neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal impairment in hypertensive patients

Chronic kidney disease (CKD) is probably the most important problem of public health in advanced countries. Kidneys are often damaged as a result of high blood pressure. One of our main concerns in patients with hypertension is early detection of kidney disorders. The routine biomarkers such as creatinine have some limitation for this purpose, however recent studies suggest plasma NGAL to be a better marker. Therefor in this study we assessed the diagnostic value of plasma NGAL and compared it with serum creatinine in hypertensive patients. This study was performed on 42 hypertensive patients and 30 healthy Volunteer, both with normal serum creatinine and urea concentration  who referred to Shohada Tajrish Hospital, plasma NGAL were measured subsequently using ELISA method and eGFR was considered  as the gold standard method(cut off value of<78ml.min.1.73m2). mean NGAL level was significantly higher in patients  in comparison to control group. The sensitivity and specificity were  96% and 100% respectively for plasma NGAL(≥32.2 ng/ml) compared with 76% and 47% for serum creatinine (>0.97 mg/dl). Our findings indicate that NGAL is a better indicator of kidney impairment in the early stages of CKD as compared with serum creatinine in hypertensive patients

Anti –MBP autoantibody changes as a predictor of response to treatment in MS patients

Myelin basic protein (MBP) is one of the most important constituents of the CNS myelin sheaths. It is supposed that an autoimmune response directed against MBP is crucial in the demyelination process in patients with multiple sclerosis. Studies have proved that free anti-MBP level in CSF of MS patients is declined when the patient entered into clinical remission. Some researchers evaluate the changes in serum or CSF level of this antibody during immunomodulatory therapy; the results are different and the relation between the changes in this antibody and response to treatment is poorly investigated. The objective of this study was to assess the relation between the changes in serum level of anti-MBP and clinical remission in patients during treatment with fingolimod. 37 MS patients that were non responder to interferon and glatiramer acetate and were candidates to receive fingolimod were nominated for this study.  In this study, the serum level of anti-MBP was evaluated before and after 3 and 6 months of therapy and clinical remission was assessed by changes in Expanded Disability Status Scale (EDSS) scores. The result of this study showed that MS patients, after treatment with interferon, have lower serum anti-MBP level than healthy control group and this difference is statistically significant (p =0.03).  The present study demonstrated that the serum anti-MBP level in MS patient during 6 months of treatment with fingolimod significantly decreased (p<0.001). However, there was no significant difference in EDSS of MS patients during 6 months of treatment with fingolimod ( p < 0.001)

Comparative Study of Serum levels of Granzyme H & Estrogen In Patients Suffering From Breast Cancer

GranymeH is a functional cytotoxic serine protease of NK cell granules,which expands the cell death-inducing repertoire of innate immune system.The purpose of this study was to determine GranymeH(GZMH)level in breast cancer(BC) and healty women.This study was performed on 30 patients with BC and 30 healty woman.GZMH and Estrogen levels were measured in cancer patients  and healty women subsequently using ELISA and Radioimmunoassay(RIA) methods. Mean GZMH value was lower in BC than healty women(p<0.0001) and  mean Estrogen level was  higher  in BC patients  in comparison to healty women (p<0.003).Our finding indicates probability of existance of suppressor or a problem in production of GZMH in cancer patient