Shared and unique transcriptional changes in the orbitofrontal cortex in psychiatric disorders and suicide

Psychiatric disorders like major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BPD), represent a significant global public health concern. Sex differences in the prevalence and presentation of psychiatric disorders, and the association of a psychiatric diagnosis with increased risk of suicide, are well-established. However, the neurobiology underlying these features of disease are not well understood. Dysfunction of the orbitofrontal cortex (OFC), a brain region responsible for decision-making and sensory processing, has been implicated in psychiatric disorders but remains understudied compared to other frontocortical brain regions.  In this study we investigated sexual dimorphism in psychiatric illnesses and suicide by analyzing publicly available OFC transcriptional profiles (RNAseq data obtained from the Stanley Neuropathology Consortium) from individuals with SCZ, BPD, MDD, and non-psychiatric controls (n=15/group).   Gene set enrichment analysis (GSEA) revealed significant differences in immune-related processes in male and female comparisons and in psychiatric disorders relative to controls. Analysis of top differentially expressed genes found changes in P2RY12 in males and females who died by suicide. Additionally, downregulation of protein folding processes was observed in female suicide subjects, suggesting an association between dysregulated protein metabolism and suicide. Our results further our understanding of the shared and unique molecular pathways underlying psychiatric disorders and suicide.

A 24-year-old Female Traumatic Patient Following a Car Accident

A healthy 24-year-old female presented at the emergency department (ED) after a car accident with ambulance while injured severely after the bus got run over her lower limb. As the trauma team was activated, her primary survey was started: Ac (Airway and cervical collar): She was awake and could talk. Cervical collar was fixed, oxygenation with face mask was started. B (Breathing): Her chest rising was symmetrical without any laceration or abrasion. Chest auscultation was clear and there was no tenderness or crepitation on palpation. No tracheal shift was found. She had normal respiratory rate and O2 saturation of 94% at ambient air. C (Circulation): Two large bore IV lines were inserted and blood samples were obtained. Her vital signs were BP = 60/40 mmHg, PR = 130/min, RR = 12. E-FAST was performed which was negative for free fluid in abdomen, pelvis and thorax, tamponade, and hemopneumothorax. Her pelvis was unstable on examination and pelvic wrapping was performed with sheath. IV fluid therapy with normal saline was started followed by 3 units of packed RBC transfusion. More pack cells and FFP were also requested. D (Disability): She had Glasgow coma scale of 15/15 with normal size and reactive pupil. No neurologic deficit was found except disability of lower extremities due to crush injury. E (Exposure): She had no midline spinal tenderness with normal sphincter anal tone, but there was a laceration in the perineum which extended to the vagina. Portable chest and pelvic x-ray as an adjutant to primary survey were performed which showed type C pelvic fracture. On her secondary survey, she had abrasion on her scalp, 1.5 cm laceration on her right tibia, deformity of her right thigh, and laceration in her genitalia with some vaginal bleeding. Direct pressure was applied and all lacerations were packed. According to negative e-FAST and pelvic fracture and shock, since the angiography was not available, it was decided to fix the pelvis with external fixator in the operation room. After the fixation, and because shock persisted, operative pelvic packing was undertaken. Unfortunately, she suffered cardiorespiratory arrest in the operating room and died

Pengaruh Komunikasi Pimpinan dan Bawahan Terhadap Kinerja Karyawan Restoran Ayam Bawang Cak Per Cabang Malang

Abstract: This research aims to understand: 1) The communication intensity level at Ayam Bawang Cak Per Restaurant, Malang Branch; 2) The employee performance at Ayam Bawang Cak Per Restaurant, Malang Branch; and 3) To know the communication influence between branch managers to employees on employee performance at Ayam Bawang Cak Per Restaurant, Malang Branch. This research used quantitative methods in the process and consist of two variables, dependent and independent. Communication is the independent variable and employee performance is the dependent variable. The research sample was taken 99% of the total population 50 people. Sampling in the study using the population sample method. Where in this case the researcher made the entire population as the research sample.The result showed that: 1) The communication intensity level between branch managers and subordinates was at a moderate level with a percentage of 75% of 30 employees; 2) The employee performance level was at the medium category with a percentage of 65% of 24 employees; and 3) There is a significant influence between communication on employee performance at Ayam Bawang Cak Per Restaurant, Malang Branch.The effective contribution or predictive power is shown by a coefficient (R2) of 0.256, which means that communication has an effect of 25.6% on employee performance, and the rest is due to variables not mentioned in this study

neurogenomics/rworkflows: v1

<h1>rworkflows 1.0.0</h1> <h2>New features</h2> <ul> <li>Synchronise <code>rworkflows</code> package versioning with <code>rworkflows</code> action Release versioning.</li> <li><code>use_vignette_docker</code>/<code>use_vignette_getstarted</code><ul> <li>Autofill <code>package</code> arg if not provided.</li> </ul> </li> </ul> <h2>Bug fixes</h2> <ul> <li><em>inst/template/docker.Rmd</em><ul> <li>Remove the need to include <code>construct_cont</code>, as not everyone will have <code>rworkfows</code> installed on the machine where the vignette is being rendered.</li> </ul> </li> <li><em>use_vignette_docker</em><ul> <li>Add <em>-autolink_bare_uris</em> bit to avoid CRAN check errors.</li> </ul> </li> <li>Change <code>\itemize</code> --> <code>describe</code> to avoid CRAN check errors.</li> </ul&gt

The similarity of Ali (as) and Jesus (PBUH) in Islamic tradition

According to the teachings of the Shia, Imam Ali (AS) has unique features by which he earned the merits of becoming the successor to the Prophet (pbuh) as the Imam and Wali. One of the most important of his features is his similarity to the Jesus as one of the greatest prophets before Prophet Muhammad (pbuh). This similarity was first mentioned in some Islamic traditions, especially the ones narrated through Shiite Isnad in interpretation of the verses 57-59 of the Surta Az-Zukhruf. In these traditions, the Prophet has regarded the Position of Imam Ali (AS) in his nation the same as Jesus's Position among the Israel. The Quran has cited the inimical arguments of the Arab infidels against this prophet's saying: they considered the worshiping of their own gods better than accepting Prophet's remark in equating his cousin with Jesus (pbuh). By resorting to this remark, the infidels regarded worshiping their own gods more preferable than deifying a man. Therefore, the first and most prominent similarity between Imam Ali (AS) and Jesus Christ (pbuh) is attributing divinity to Imam Ali (AS), at least by some of his extreme lovers. The Quranic command saying: "Do not Exaggerate about your religion… .(Quran 4:17) refers to the Christian extremism in deifying Jesus, But soon word Ghali was borrowed from this verse and used to refer to Shiite extremists. Moreover, the Quran (4: 159), talks about the advent of Jesus Christ to his followers before their death .The same concept has been mentioned in Shiite traditions about Imam Ali (AS), according to which, he is believed to be present beside every dying Muslim individual. This appearance of Imam Ali (AS) would remind us the idea of Imam Ali's (AS) return to this world. Thus, the return of Imam Ali (AS) to this world is the third similarity between Imam Ali (AS) and Jesus Christ (PBUH). Not only the return of Jesus has been mentioned in in the Christian tradition as the one manifested to the apostles after his ascension and also his return as the Messiah, the savior of the world, but in the Islamic tradition and the Koran (AZ-ZUKHRUF: 61) it is also pointed out that Jesus's (pbuh ) return is certainly a sign for resurrection. It is so interesting that in Shiite commentaries under this verse and other Quranic verses (Naml:2) the return of Imam Ali (AS) to the world has been mentioned as eschatological signs. This return happens due to the high position of Jesus Christ and Ali (AS) both of whom in Christian and Shiite traditions possess the two concepts of ascending and descending. It is narrated from Imam Ali (AS) that he described himself as having the quality of return. The reflection of such remarks among the Shiite extremists led to the denial of Imam Ali's death and his divinity. The extremists who were known as Nasiris expressed the divinity of Imam Ali (AS) in the form of trinity and in Baktashi Sufism; this concept has been elaborated as the three hypostases of Allah, Muhammad and Ali. In Ibn Arabi mysticism the divinity has been manifested in ultimate authority he considers for both of them. Besides all these similarities, the miracles done by Imam Ali (like: the revival of the dead, speaking in the cradle, and rising in the clouds) are all similar to the ones narrated for Jesus Christ. Furthermore, Imam Ali's moral features like his chivalry and piety match the qualities of Jesus inferred from his biography

neurogenomics/rworkflows: v1

<h1>rworkflows 1.0.0</h1> <h2>New features</h2> <ul> <li>Synchronise <code>rworkflows</code> package versioning with <code>rworkflows</code> action Release versioning.</li> <li><code>use_vignette_docker</code>/<code>use_vignette_getstarted</code><ul> <li>Autofill <code>package</code> arg if not provided.</li> </ul> </li> </ul> <h2>Bug fixes</h2> <ul> <li><em>inst/template/docker.Rmd</em><ul> <li>Remove the need to include <code>construct_cont</code>, as not everyone will have <code>rworkfows</code> installed on the machine where the vignette is being rendered.</li> </ul> </li> <li><em>use_vignette_docker</em><ul> <li>Add <em>-autolink_bare_uris</em> bit to avoid CRAN check errors.</li> </ul> </li> </ul&gt

neurogenomics/rworkflows: v0

Continuous integration for R packages. Automates testing ✅, documentation website building , & containerised deployment

neurogenomics/rworkflows: v0

Continuous integration for R packages. Automates testing ✅, documentation website building , & containerised deployment

neurogenomics/rworkflows: v1

Continuous integration for R packages. Automates testing ✅, documentation website building , & containerised deployment

The metabolic syndrome and nonfatal ischemic heart disease; a population-based study

Objectives: Metabolic syndrome comprises insulin resistance, abdominal fat distribution, dyslipidemia and hypertension. The metabolic syndrome is expected to be diagnosed in millions of subjects in the near future worldwide. There are very few data in literature clearly documenting that subjects with metabolic syndrome have an increased cardiovascular risk. Design: Cross-sectional, population-based study. Materials and methods: We used National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP)-III criteria and Minnesota Code of a 12-lead resting electrocardiogram (EKG) to assess the association of metabolic syndrome and nonfatal ischemic heart disease in 3723 subjects, aged 25 years and over, selected by cluster random sampling in three Iranian ports in the northern Persian Gulf. Electrocardiogram with evidence of IHD (IHD EKG) was defined as myocardial infarction (codes 1.1 and 1.2) and ischemia (codes 1.3, 4.1– 4.4, 5.1–5.3 and 7.1) together. Results: An estimated 49.08% (52.04% of males and 46.34% of females) were identified as fulfilling NCEP-ATP III criteria for diagnosing the metabolic syndrome. Prevalence of EKG with evidence of ischemic heart disease (IHD EKG) was 12.7% (10.4% for men and 14.7% for women, pb0.0001). In multiple logistic regression analysis, metabolic syndrome was found to have a significant association with IHD EKG [OR=1.35, CI (1.09–1.66), p=0.005] after adjusting for sex and age. Of the metabolic syndrome components, elevated blood sugar (OR=2.69, pb0.001), high blood pressure (OR=1.79, p=0.001) and low HDL-C (OR=1.27, p=0.02) had significant independent association with IHD EKG. Conclusion: The metabolic syndrome, which occurs very frequently in the general population, has a significant association with nonfatal ischemic heart disease by electrocardiogram criteria. © 2006 Elsevier Ireland Ltd. All rights reserved