Estimation of macro and micro nutrients in some important medicinal plants of Soon Valley, District Khushab, Pakistan

Plants are potential source of therapeutic values in different traditional medicine systems of the world. Ethnomedicinal uses of 10 medicinal plants (MPs) of soon valley (Khushab) of Pakistan were documented and explored for trace (Zn, Cu, Cr, Ni, Co, Cd, Pb, Mn and Fe) and major (K, Na, Ca and Mg) elemental composition by atomic absorption spectrophotometer (AAS). Results depicted that Zn was 15.36 ppm in Convolvulus arvensis. Cu showed max conc. was in P. harmala (18.72 ppm). Cr was highest in Cannabis sativa (30.39 ppm). Ni conc was 30.39 ppm in C. sativa. B. campestris had highest value of Co (8.44 ppm) in analyzed specimens, while H. vulgare recorded least amount of 0.98 ppm. Cd concentration was 2.76 ppm in A. aspera. H. vulgare exhibited higher Pb higher concentration (32.64 ppm). The occurrence range of Mn was 74.60 ppm in P. harmala and 105.56 ppm in A. aspera. Fe in the studied plants was max in H. vulgare (1889.69 ppm). B. campestris exhibited higher concentration of Ca (4210.92 ppm). The contents of Mg were 13342.88 ppm in C. arvensis and 6350.63 ppm in A. aspera, respectively. The quantity of macro and micro elements in analyzed MPs was high and beyond the safety standards of WHO. It demonstrates that use of botanical medicines or its products by man may be fatal and injurious for health and culminating into death. It is necessary to study and accomplish thorough analytical research on herbal medicines (MPs) of Pakistan in order to bring them at par with international standards.Key words: Soon valley, elemental contents, medicinal plants, safety standards, Khushab, Pakistan

Machine learning-based country-level annual air pollutants exploration using Sentinel-5P and Google Earth Engine

Climatic condition is triggering human health emergencies and earth’s surface changes. Anthropogenic activities, such as built-up expansion, transportation development, industrial works, and some extreme phases, are the main reason for climate change and global warming. Air pollutants are increased gradually due to anthropogenic activities and triggering the earth’s health. Nitrogen Dioxide (NO2), Carbon Monoxide (CO), and Aerosol Optical Depth (AOD) are truthfully important for air quality measurement because those air pollutants are more harmful to the environment and human’s health. Earth observational Sentinel-5P is applied for monitoring the air pollutant and chemical conditions in the atmosphere from 2018 to 2021. The cloud computing-based Google Earth Engine (GEE) platform is applied for monitoring those air pollutants and chemical components in the atmosphere. The NO2 variation indicates high during the time because of the anthropogenic activities. Carbon Monoxide (CO) is also located high between two 1-month different maps. The 2020 and 2021 results indicate AQI change is high where 2018 and 2019 indicates low AQI throughout the year. The Kolkata have seven AQI monitoring station where high nitrogen dioxide recorded 102 (2018), 48 (2019), 26 (2020) and 98 (2021), where Delhi AQI stations recorded 99 (2018), 49 (2019), 37 (2020), and 107 (2021). Delhi, Kolkata, Mumbai, Pune, and Chennai recorded huge fluctuations of air pollutants during the study periods, where ~ 50–60% NO2 was recorded as high in the recent time. The AOD was noticed high in Uttar Pradesh in 2020. These results indicate that air pollutant investigation is much necessary for future planning and management otherwise; our planet earth is mostly affected by the anthropogenic and climatic conditions where maybe life does not exist.Validerad;2023;Nivå 2;2023-05-22 (hanlid)</p

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

10.1038/s41467-022-30053-9NATURE COMMUNICATIONS13

Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

Ototoxicity is a major adverse effect of platinum-based chemotherapeutics and currently, there remains a lack of United States Food and Drug Administration-approved therapies to prevent or treat this problem. In our study, we examined the role of the sphingosine 1-phosphate receptor 2 (S1P2) in attenuating cisplatin-induced ototoxicity in several different animal models and cell lines. We found that ototoxicity in S1P2 knockout mice is dependent on reactive oxygen species (ROS) production and that S1P2 receptor activation with a specific agonist, CYM-5478, significantly attenuates cisplatin-induced defects, including hair cell degeneration in zebrafish and prolonged auditory brainstem response latency in rats. We also evaluated the cytoprotective effect of CYM-5478 across different cell lines and showed that CYM-5478 protects neural-derived cell lines but not breast cancer cells against cisplatin toxicity. We show that this selective protection of CYM-5478 is due to its differential effects on key regulators of apoptosis between neural cells and breast cancer cells. Overall, our study suggests that targeting the S1P2 receptor represents a promising therapeutic approach for the treatment of cisplatin-induced ototoxicity in cancer patients

Groundwater level prediction using machine learning models: A comprehensive review

Validerad;2022;Nivå 2;2022-03-23 (joosat)</p