Stochastic Analysis and Performance Evaluation of a Complex Thermal Power Plant

This paper present the stochastic analysis and performance evaluation of the thermal power plant which serve as an improvement of Vora 2011, by the use of performance evaluation using probabilistic approach. The research study consists mainly three sub-systems namely boiler, super heater and re-heater connected in series configuration with two type of preventive maintenance ie offline and online. The analysis shows that as failure rate increases, the availability decreases and as repair rate increases, the availability of the system increases and vice-versa. Performance matrices shows that Super heater subsystem is the most critical subsystem among the three subsystems in the power generation plant as far as maintenance is concern, as its availability percentage is the least among the three subsystem and boiler subsystem is having the higher percentage of availability with about 99% level. The results of the analysis are found beneficial to the plant management for the availability analysis of the system. Key words: Reliability, Availability, Maintainability

Availability Determination of a Complex Repairable Series- Parallel System Using Markovian Birth-Death Process

Availability and profit of an industrial system are becoming an increasingly important issue. This paper dealt with the evaluation of availability of a redundant system. The system considered consists of four subsystems arranged in series-parallel. Performance evaluation model for the availability based on Markovian Birth-Death process using probabilistic approach was formulated. A transition diagram representing the operational behavior of the system has been constructed. Failure and repair rates of subsystems were kept constant. It was found that as the availability of a system increases, the related profit will also increase

Laparoscopic vs. small incision cholecystectomy: Implications for pulmonary function and pain. A randomized clinical trial.

Item does not contain fulltextBACKGROUND: Upper abdominal surgery, including laparoscopic cholecystectomy (LC), is associated with post-operative pulmonary dysfunction. LC has, by consensus, become the treatment of choice for symptomatic cholecystolithiasis. The small-incision cholecystectomy (SIC), a procedure which does not require a pneumoperitoneum threatens to be lost to clinical practice even though there is evidence of equality. We hypothesized that the SIC technique should be equal and might even be superior to the LC when considering post-operative pulmonary function due to the short incision length. METHODS: A single-centre, randomized clinical trial was performed including patients scheduled for elective cholecystectomy. Pulmonary flow-volume curves were measured pre-operatively, post-operatively, and at follow up. Blood gas analyses were measured pre-operative, in the recovery phase and on post-operative day 1. Anaesthesia, analgesics, and peri-operative care were standardized by protocol. Post-operatively, patients and caregivers were blinded to the procedure. RESULTS: A total of 257 patients were analysed. There was one pulmonary complication (pneumonia) in the LC group. In both groups, similar reductions of approximately 20% in pulmonary function parameters occurred, with complete recovery to pre-operative values. Patients in the SIC group consumed more analgesia when compared with the LC group without impact on blood gas analysis. Patients converted to a conventional open technique showed significant differences in six of the eight parameters in pulmonary function tests. CONCLUSION: When evaluated with strict methodology and standardization of care, no clinically relevant differences were found between SIC and LC regarding pulmonary function. Our results suggest that the popularity of the laparoscopic technique cannot be attributed to pulmonary preservation

Tailoring midazolam-loaded chitosan nanoparticulate formulation for enhanced brain delivery via intranasal route

10.3390/polym12112589Polymers1211Jan-1

α-glucosidase inhibitors isolated from Mimosa pudica L.

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group