8 research outputs found

    Additional file 2: Figure S2. of NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

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    Correlation analysis between Helicobacter Pylori (H. Pylori) infection and NOTCH1-4 mRNA expression. (TIF 698 kb

    Additional file 1: Table S1. of IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

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    Oligonucleotides used in the luciferase activity experiments. The oligonucleotides were annealed and subcloned into pMIR-REPORT via HindIII and SpeI restriction sites. WT (Wild type), full length of the putative miRNA binding site; Mutation, the binding site was mutated. (DOC 34 kb

    Additional file 1: Figure S1. of miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-ÎşB signaling in gastric carcinogenesis

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    Functional study of NFKB1 and RELA knockdown. (A) The representative figures of cell invasion in three GC cell lines (MKN28, MGC-803, and SGC-7901) after treatment with siScramble, siNFKB1 or siRELA. (B) The cell migration images of GC cell upon NFKB1 or RELA knockdown. (C) The representative cell cycle distribution images from FACS flow cytometry analysis in siScramble, siNFKb1 or siRELA transfectants. (D) siNFKB1 and siRELA significantly supressed the xenograft formation in a 28-day inoculation using MGC-803 cells. (TIF 5626 kb
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