Additional file 1: Figure S1. of Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

In the highly predicted pathway ‘Fatty acid metabolism’ [hsa00071] targets of miR-31-5p are highlighted. Relevant pathways predicted to be targeted by the differentially expressed miRNAs. (PPTX 64 kb

Additional file 3: Figure S3. of Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

Targets actively regulated by miRNAs in “Arrhythmogenic right ventricular cardiomyopathy” pathway. (PPTX 301 kb

IOTF obesity risk of early life course factors.

a<p>Analyses were matched on sex, age and country.</p>b<p>Analyses were additionally adjusted for putative confounders (see last column).</p><p>Matched odds ratios (OR) and 95% confidence intervals (95% CI): OR with p<0.05 are printed in bold.</p

Risk factors investigated in the study.

<p>Risk factors investigated in the study.</p

Description of the study sample.

<p>Description of the study sample.</p

Multivariate models for pre-, peri- and postpartum risk factors on IOTF obesity risk.

a<p>Analyses were matched on sex, age and country.</p>b<p>Analyses were additionally adjusted for all parameters in the respective column.</p><p>Matched odds ratios (OR), 95% confidence intervals (95% CI) and Wald-statistics (Wald): OR with p<0.05 are printed in bold.</p

Anthropometric variables at T0 according to <i>FTO</i> rs9939609 genotypes.

<p>Values are mean (95% confidence interval (CI)).</p><p>Multiple regression analysis adjusted for age, sex and country of origin.</p><p>BMI = body mass index; WC = waist circumference; SS = sum of skinfolds (subscapular + tricipital); W/H = waist-to-height ratio.</p

Prevalence of overweight/obesity at T0 and T1 and incidence over the two-year follow-up, according to <i>FTO</i> rs9939609 genotypes.

<p>p for χ2 statistics.</p

Two-year variation in anthropometric variables according to <i>FTO</i> rs9939609 genotypes.

<p>Values are mean (95% confidence interval (CI)).</p><p>Multiple regression analysis adjusted for age, sex, country of origin, intervention/control study group, T0 values of the examined variables and individual time interval between T0 and T1.</p><p>BMI = body mass index; WC = waist circumference; SS = sum of skinfolds (subscapular + tricipital); W/H = waist-to-height ratio. ΔBMI = (BMI at T1) - (BMI at T0); ΔWC = (WC at T1) - (WC at T0); ΔSS = (SS at T1) - (SS at T0); ΔW/H = (W/H at T1) - (W/H at T0).</p

Predicted BMI growth trajectories of children having a mother with a BMI of 20 kg/m² (solid) vs. with a BMI of 25 kg/m² (dashed) by sex (girls: black; boys: grey) and country; all other covariates were set to a constant value (continuous covariates were set to 0 (i.e. to the value used for centring), categorical variables were set to the reference category).

<p>Predicted BMI growth trajectories of children having a mother with a BMI of 20 kg/m² (solid) vs. with a BMI of 25 kg/m² (dashed) by sex (girls: black; boys: grey) and country; all other covariates were set to a constant value (continuous covariates were set to 0 (i.e. to the value used for centring), categorical variables were set to the reference category).</p