18 research outputs found
Combined effect of obesity and diabetes on early breast cancer outcome: A prospective observational study
Background: Previous studies suggested that obesity and diabetes were correlated
with breast cancer outcome. The aim of the present study was to investigate the
prognostic effect of obesity and diabetes on the outcome of early breast cancer patients.
Materials and Methods: Overall, 841 early breast cancer patients were
prospectively enrolled between January 2009 and December 2013. Study population
was divided into four groups: (1) patients without obesity or diabetes; (2) patients
with only diabetes; (3) patients with only obesity; and (4) patients with both diabetes
and obesity. Categorical variables were analyzed by the chi-square test and survival
data by the log-rank test.
Results: At diagnosis, obese and diabetic patients were more likely to be older
(p < 0.0001) and post-menopausal (p < 0.0001) and to have a tumor larger than 2 cm
(p < 0.0001) than patients in groups 1–3. At univariate analyses, obese and diabetic
patients had a worse disease-free survival (p = 0.01) and overall survival (p = 0.001)
than did patients without obesity and diabetes. At multivariate analyses, the
co-presence of obesity and diabetes was an independent prognostic factor for diseasefree
survival (hazard ratio=2.62, 95% CI 1.23–5.60) but not for overall survival.
Conclusions: At diagnosis, patients with obesity and diabetes were older, had
larger tumors and a worse outcome compared to patients without obesity or diabetes.
These data suggest that metabolic health influences the prognosis of patients affected
by early breast cance
Handbook of Active Ageing and Quality of Life: From Concepts to Applications
La edición de este libro estuvo a cargo de Fermina Rojo-Pérez y Gloria Fernández-Mayoralas.El documento adjunto contiene la cubierta, portada e índice del libro.This handbook presents an overview of studies on the relationship of active ageing and quality of life. It addresses the new challenges of ageing from the paradigm of positive ageing (active, healthy and successful) for a better quality of life. It provides theoretical perspectives and empirical studies, including scientific knowledge as well as practical experiences about the good ageing and the quality of later life around the world, in order to respond to the challenges of an aged population. The handbook is structured in 4 sections covering theoretical and conceptual perspectives, social policy issues and research agenda, methods, measurement instrument-scales and evaluations, and lastly application studies including domains and geographical contexts.Peer reviewe
Experimental identification of the subarachnoid and subpial compartments by intracranial pressure measurements
Vesico-vaginal fistula and bladder stone caused by a protruding spiral tacker 4 years after a laparoscopic sacrocolpopexy: Case report
Our case report demonstrates that the use of tackers or other devices in a improper way should be avoid and it can be correlated with late complication of laparoscopic colposacropexy
Intracranial pressure measurements and rheological behavior of the intracranial system in dogs
Peritoneal Carcinosis: What the Radiologist Needs to Know
Peritoneal carcinosis is a condition characterized by the spread of cancer cells to the peritoneum, which is the thin membrane that lines the abdominal cavity. It is a serious condition that can result from many different types of cancer, including ovarian, colon, stomach, pancreatic, and appendix cancer. The diagnosis and quantification of lesions in peritoneal carcinosis are critical in the management of patients with the condition, and imaging plays a central role in this process. Radiologists play a vital role in the multidisciplinary management of patients with peritoneal carcinosis. They need to have a thorough understanding of the pathophysiology of the condition, the underlying neoplasms, and the typical imaging findings. In addition, they need to be aware of the differential diagnoses and the advantages and disadvantages of the various imaging methods available. Imaging plays a central role in the diagnosis and quantification of lesions, and radiologists play a critical role in this process. Ultrasound, computed tomography, magnetic resonance, and PET/CT scans are used to diagnose peritoneal carcinosis. Each imaging procedure has advantages and disadvantages, and particular imaging techniques are recommended based on patient conditions. Our aim is to provide knowledge to radiologists regarding appropriate techniques, imaging findings, differential diagnoses, and treatment options. With the advent of AI in oncology, the future of precision medicine appears promising, and the interconnection between structured reporting and AI is likely to improve diagnostic accuracy and treatment outcomes for patients with peritoneal carcinosis