The Trusted UHF Receiver for Radio Frequency Identification of Critical Infrastructure Objects

Results of designing the low-noise amplifier, quadrature demodulator, and baseband amplifier with an integrated low-pass filter for the UHF radio frequency identification receiver are presented. IP-blocks are designed for implementation in the domestic CMOS 180 nm technology process. The low-noise amplifier is implemented with integrated single pole double throw switches based on the MOSFETs which are needed for bypass mode realization at the RF input. The benefits of this approach are increased input linearity of the receiver by no less than 30 dB with an increase of a noise figure. The quadrature demodulator is realized according to a typical design based on the passive MOSFET mixer core. The programmable-gain baseband amplifier is implemented with an integrated low-pass filter based on Tow-Thomas biquad architecture. IP-blocks designed for use in an RFID reader transceiver VLSI IC with sensitivity value no more than -75 dBm and input linearity value not less than 10 dBm in a «Talk» mode. The trustiness of the receiver is provided by the full-cycle design procedure and verification under experimental investigation. The electric parameters values of the proposed receiver correspond to foreign VLSIs implemented in a CMOS process with the same technology nodes. Thus, it is important to design the domestic ISO 18000-6C reader equipment intended for critical infrastructure

The Design Technique for Power Management Unit of the Tag IC for Radio Frequency Identification of Critical Infrastructure Objects

The ultra-high frequency (UHF) tag IC’s main part of the power management unit (PMU) design technique is presented. The technique is a step-by-step algorithm for designing a PMU and consists of five interrelated stages. At the first stage, the requirements for the parameters of the PMU (output voltage, output DC power, efficiency, output capacitor capacity) and the Q-factor of the tag analog front-end are determinates. At the second stage, the design of an electrical circuit of a voltage multiplier (VM) is carried out. VM is required to convert the voltage of the input radio frequency (RF) signal into an DC voltage. During the third stage, the design of the electrical circuit of the DC voltage limiter is carried out, which is necessary to reduce the output voltage of VM to a safe level. The result of stage 4 is an electrical circuit of surge protection designed to provide the required level of immunity of the tag IC to the effects of electrostatic discharge and a high-power RF signal. As part of the final stage, the evaluation and alignment with the required Q-factor value of the tag IC analog front-end is carried out. The proposed technique can be used for the development of domestic UHF tag ICs (ISO 18000-6C, GJB 7377.1, etc.) based on CMOS technological processes, including ICs designed for radio frequency identification of critical infrastructure objects. Using the presented technique, the design of a PMU with an estimated efficiency value of 70%, an estimated Q-factor of the analog front-end of less than 15 at an RF input signal power of -12.7 dBm was performed

GQIcombi application to subdue glioma via differentiation therapy

Current therapy protocols fail to cure high-grade gliomas and prevent recurrence. Therefore, novel approaches need to be developed. A re-programing of glioma cell fate is an alternative attractive way to stop tumor growth. The two-step protocol applies the antiproliferative GQ bi-(AID-1-T) and small molecule inducers with BDNF to trigger neural differentiation into terminally differentiated cells, and it is very effective on GB cell cultures. This original approach is a successful example of the “differentiation therapy”. To demonstrate a versatility of this approach, in this publication we have extended a palette of cell cultures to gliomas of II, III and IV Grades, and proved an applicability of that version of differential therapy for a variety of tumor cells. We have justified a sequential mode of adding of GQIcombi components to the glioma cells. We have shown a significant retardation of tumor growth after a direct injection of GQIcombi into the tumor in rat brain, model 101/8. Thus, the proposed strategy of influencing on cancer cell growth is applicable to be further translated for therapy use

Prospects of Geoinformatics in Analyzing Spatial Heterogeneities of Microstructural Properties of a Tectonic Fault

The paper proposes a special technique for microstructural analysis (STMA) of rock samples based on two provisions. The first one is an algorithm for the automatic detection and digitalization of microstructures in images of oriented thin sections. The second one utilizes geographic information system (GIS) tools for an automatized analysis of objects at the micro scale. Using STMA allows the establishment of geometric features of fissure and pore space of rock samples to determine the parameters of stress–strain fields at different stages of rock massif deformation and to establish a relationship between microstructures and macrostructures. STMA makes it possible to evaluate the spatial heterogeneity of physical and structural properties of rocks at the micro scale. Verification of STMA was carried out using 15 rock samples collected across the core of the Primorsky Fault of the Baikal Rift Zone. Petrographic data were compared to the quantitative parameters of microfracture networks. The damage zone of the Primorsky Fault includes three clusters characterized by different porosity, permeability, and deformation type. Findings point to the efficiency of STMA in revealing the spatial heterogeneity of a tectonic fault

A Novel Photoswitchable Azobenzene-Containing Local Anesthetic Ethercaine with Light-Controlled Biological Activity In Vivo

Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity particularly important. Photopharmacology makes it possible to reduce the side effects of an anesthetic and control its biological activity in the body. The purpose of this work was to create a new light-controlled local anesthetic and study its biological activity in animals. A compound with a simple scheme of synthesis was chosen to shift the UV-Vis absorption band towards the visible range of the spectrum and was synthesized for the first time. Some computer calculations were performed to make sure that the aforementioned changes would not lead to loss of biological activity. The micellar form of the new compound was prepared, and in vivo biological studies were carried out in rabbits. The existence of a local anesthetic effect, which disappeared almost completely on irradiation with light (λ = 395 nm), was shown using the surface anesthesia model. Moreover, the possibility of multiple reversible changes in the biological activity of ethercaine under the action of light was demonstrated. The latter compound manifests no local irritating effect, either. The data obtained indicate the prospects for the development of new compounds based on azobenzene for light-controlled local anesthesia

The Specialized RF Elements Library for Trusted Transceiver VLSI Design

Results of designing the specialized RF elements library intended for use in the CMOS 180 nm process are presented. The RF library includes a set of RF MOSFETs for amplifiers and switches design,  three types of varactors based on the MOS-structure, spiral inductors, MIM-capacitors and other elements. The RF library is intended for use in combination with CAD Cadence Virtuoso IC and is focused on designing a set of amplifiers, frequency oscillators and convertors, controlled attenuators and phase shifters microwave IP-blocks of the transceiver VLSI. A test chip is developed with using the presented RF library, focused on conducting research by probe methods and containing 13 types of basic elements and specialized structures for the RF characterization of the domestic CMOS 180 nm process

Internal Carotid Artery Injury in Transsphenoidal Surgery: Tenets for Its Avoidance and Refit—A Clinical Study

One of the most serious/potentially fatal complications of transsphenoidal surgery (TSS) is internal carotid artery (ICA) injury. Of 6230 patients who underwent TSS, ICA injury occurred in 8 (0.12%). The etiology, possible treatment options, and avoidance of ICA injury were analyzed. ICA injury occurred at two different stages: (1) during the exposure of the sella floor and dural incision over the sella and cavernous sinus and (2) during the resection of the cavernous sinus extension of the tumor. The angiographic collateral blood supply was categorized as good, sufficient, and nonsufficient to help with the decision making for repairing the injury. ICA occlusion with a balloon was performed at the injury site in two cases, microcoils in two patients, microcoils plus a single barrel extra-intracranial high-flow bypass in one case, stent grafting in one case, and no intervention in two cases. The risk of ICA injury diminishes with better preoperative preparation, intraoperative navigation, and ultrasound dopplerography. Reconstructive surgery for closing the defect and restoring the blood flow to the artery should be assessed depending on the site of the injury and the anatomical features of the ICA

Internal Carotid Artery Injury in Transsphenoidal Surgery: Tenets for Its Avoidance and Refit—A Clinical Study

One of the most serious/potentially fatal complications of transsphenoidal surgery (TSS) is internal carotid artery (ICA) injury. Of 6230 patients who underwent TSS, ICA injury occurred in 8 (0.12%). The etiology, possible treatment options, and avoidance of ICA injury were analyzed. ICA injury occurred at two different stages: (1) during the exposure of the sella floor and dural incision over the sella and cavernous sinus and (2) during the resection of the cavernous sinus extension of the tumor. The angiographic collateral blood supply was categorized as good, sufficient, and nonsufficient to help with the decision making for repairing the injury. ICA occlusion with a balloon was performed at the injury site in two cases, microcoils in two patients, microcoils plus a single barrel extra-intracranial high-flow bypass in one case, stent grafting in one case, and no intervention in two cases. The risk of ICA injury diminishes with better preoperative preparation, intraoperative navigation, and ultrasound dopplerography. Reconstructive surgery for closing the defect and restoring the blood flow to the artery should be assessed depending on the site of the injury and the anatomical features of the ICA

Influence of temporal variations in plasma conditions on the electric potential near self-organized dust chains

Self-organization of dust grains into stable filamentary dust structures (or “chains”) largely depends on dynamic interactions between individual charged dust grains and complex electric potential arising from the distribution of charges within a local plasma environment. Recent studies have shown that the positive column of the gas discharge plasma in the Plasmakristall-4 (PK-4) experiment at the International Space Station supports the presence of fast-moving ionization waves, which lead to variations of plasma parameters by up to an order of magnitude from the average background values. The highly variable environment resulting from ionization waves may have interesting implications for the dynamics and self-organization of dust particles, particularly concerning the formation and stability of dust chains. Here, we investigate the electric potential surrounding dust chains in the PK-4 experiment by employing a molecular dynamics model of the dust and ions with boundary conditions supplied by a particle-in-cell with Monte Carlo collision simulation of the ionization waves. The model is used to examine the effects of the plasma conditions within different regions of the ionization wave and compare the resulting dust structure to that obtained by employing the time-averaged plasma conditions. The comparison between simulated dust chains and experimental data from the PK-4 experiment shows that the time-averaged plasma conditions do not accurately reproduce observed results for dust behavior, indicating that more careful treatment of plasma conditions in the presence of ionization waves is required. It is further shown that commonly used analytic forms of the electric potential do not accurately describe the electric potential near charged dust grains under these plasma conditions