1 research outputs found
Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion
A method for nucleophilic difluoromethylation
of reactive Michael
acceptors, aldehydes, and azomethines is described. The reaction is
performed using the readily available and air-stable reagent difluoromethylene
phosphabetaine. The process involves interaction of an electrophilic
substrate with in situ generated difluorinated phosphonium ylide followed
by hydrolysis of the carbon–phosphorus bond under mild conditions