Difluoromethylene Phosphabetaine as an Equivalent
of Difluoromethyl Carbanion
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Abstract
A method for nucleophilic difluoromethylation
of reactive Michael
acceptors, aldehydes, and azomethines is described. The reaction is
performed using the readily available and air-stable reagent difluoromethylene
phosphabetaine. The process involves interaction of an electrophilic
substrate with in situ generated difluorinated phosphonium ylide followed
by hydrolysis of the carbon–phosphorus bond under mild conditions