Analysis, Design and Evaluation of an Interactive System to Support Dementia Patients and Integrate Carers

mobileWAY is an application for both tablets and smartphones which enables carers of dementia affected persons to remotely display dynamic, customized and illustrated information directly on the television of the dementia patient. In particular, mobileWAY enables caregivers to provide information about their identity, their whereabouts and the time remaining until they return to the home of the patient and thus supports dementia patients at home in situations of temporary lonesomeness and absence through information

462 Machine Translation Systems for Europe

We built 462 machine translation systems for all language pairs of the Acquis Communautaire corpus. We report and analyse the performance of these system, and compare them against pivot translation and a number of system combination methods (multi-pivot, multisource) that are possible due to the available systems.JRC.G.2-Global security and crisis managemen

Reassembling gastrulation

During development, a single cell is transformed into a highly complex organism through progressive cell division, specification and rearrangement. An important prerequisite for the emergence of patterns within the developing organism is to establish asymmetries at various scales, ranging from individual cells to the entire embryo, eventually giving rise to the different body structures. This becomes especially apparent during gastrulation, when the earliest major lineage restriction events lead to the formation of the different germ layers. Traditionally, the unfolding of the developmental program from symmetry breaking to germ layer formation has been studied by dissecting the contributions of different signaling pathways and cellular rearrangements in the in vivo context of intact embryos. Recent efforts, using the intrinsic capacity of embryonic stem cells to self-assemble and generate embryo-like structures de novo, have opened new avenues for understanding the many ways by which an embryo can be built and the influence of extrinsic factors therein. Here, we discuss and compare divergent and conserved strategies leading to germ layer formation in embryos as compared to in vitro systems, their upstream molecular cascades and the role of extrinsic factors in this process

Integrals over Gaussians under Linear Domain Constraints

Integrals of linearly constrained multivariate Gaussian densities are a frequent problem in machine learning and statistics, arising in tasks like generalized linear models and Bayesian optimization. Yet they are notoriously hard to compute, and to further complicate matters, the numerical values of such integrals may be very small. We present an efficient black-box algorithm that exploits geometry for the estimation of integrals over a small, truncated Gaussian volume, and to simulate therefrom. Our algorithm uses the Holmes-Diaconis-Ross (HDR) method combined with an analytic version of elliptical slice sampling (ESS). Adapted to the linear setting, ESS allows for rejection-free sampling, because intersections of ellipses and domain boundaries have closed-form solutions. The key idea of HDR is to decompose the integral into easier-to-compute conditional probabilities by using a sequence of nested domains. Remarkably, it allows for direct computation of the logarithm of the integral value and thus enables the computation of extremely small probability masses. We demonstrate the effectiveness of our tailored combination of HDR and ESS on high-dimensional integrals and on entropy search for Bayesian optimization