Accessibility 101: A Researcher’s Guide to Making Content Accessible

What is accessibility? Accessibility refers to whether a product or service is usable by all regardless of disability status. Principles of accessibility are not limited to physical spaces (such as stairs or curbs) – the same principles apply to websites and public facing documents. There are guidelines to follow to make documents, web pages, presentations, products, and research findings more accessible to people with disabilities. This tip sheet offers an introduction to accessibility and will be followed by tip sheets that focus on specifics. Visit the CeKTER website

Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.

Treatment strategies for advanced malignancy remain limited in their success, despite major advances in the understanding of cancer aetiology and molecular biology. The incidence of many cancers, including melanoma, continues to rise, with a huge demand for therapies even if treatment goals are purely cytostatic. One particular therapeutic strategy is the metronomic (continuous and low) dosing of conventional chemotherapy. There is evidence to suggest that tumour vasculature is the main target of this dosing schedule resulting in an overall ‘non specific’ anti-angiogenic effect. It is now being studied in clinical trials alone and in combination with specific antiangiogenic agents.This thesis had two main aims: firstly to investigate the additive or synergistic antiendothelial effects of a number of conventional cytotoxic agents (Temozolomide, Paclitaxel, Vinorelbine, Etoposide, Carboplatin) in vitro given in a metronomic schedule in combination with a specific anti-angiogenic compound (Sorafenib) and a non-specific sompound (Combretastatin). The anti-proliferative, cytotoxic activities of the metronomic combinatorial schedules were assessed on microvascular endothelial cells and cancer cells using an MTT proliferation assay. Results confirmed significant (

Knowledge Systems and Risk Management: Towards a Risk and Threat Assessment Framework

Knowledge is the most important asset that a company can have. Thus, it is imperative that this asset is safeguarded just like generic information assets. However, knowledge management (KM) and knowledge systems are different than traditional information systems with different threats and different operational requirements. Risk assessment is the corner stone to security. This paper discusses risk assessment. frameworks and builds on a KM/knowledge system specific risk assessment framework with a step-by-step guideline for managers as well as a generic KM/knowledge system specific threat assessment

The Effect of Retro-Cueing on an ERP Marker of VSTM Maintenance

Previous research has found that Contralateral Delay Activity (CDA) is correlated with the number of items maintained in Visual Short Term Memory from one visual field (VF) (Vogel & Machizawa, 2004). CDA is usually elicited by a to-be-remembered array after a prospective cue (pro-cue) signalling the relevant side of the visual display, and is interpreted as a putative electrophysiological signature of WM maintenance. Attention can also be directed to the contents of VSTM, after the presentation of a visual array, using a retroactive cue (retro-cue) (Nobre, Griffin, & Rao, 2008). Because retro-cueing directs attention within a memory trace, potentially reducing the load of items to be maintained, we hypothesised that this would significantly attenuate the CDA. Participants were initially presented with a spatial pro-cue which reduced the number of to-be-remembered items to one side. After a delay, a memory array of either four (low load) or eight (high load) items was displayed. A retro-cue then cued participants to one location within the relevant VF, further reducing the load of to-be-remembered items; or provided no information, requiring participants to hold all items in the relevant VF. At the end of the trial, participants performed a same/different judgement on a test stimulus. Retro-cues significantly improved VSTM performance. Unexpectedly, the CDA was found to be abolished by the presentation of both spatially predictive and neutral cues, independently of the VSTM load participants had to maintain

Introduction to Confidentiality, Integrity, and Availability of Knowledge and Data Minitrack

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Talking about sunbed tanning: Social representations and identity-work

Rationale Despite the publicised health risks associated with its usage, sunbed tanning remains popular in many Western countries. Previous research indicates that knowledge of the harmful effects does not necessarily lead to a reduction in sunbed use. Objective The aim of this study was to develop a more extensive social psychological understanding of sunbed use, in the United Kingdom, by exploring the social representations of sunbed tanning held by both those who use and who have never used sunbeds. Method Semi-structured interviews were conducted with 15 sunbed users and 10 who had never used a sunbed. Results A thematic analysis identified two dimensions in the social representations of both the users and non-users; these were concerned with a) health and b) beauty. However, whereas non-users emphasised the health risks, users downplayed and minimised them, instead emphasising the health benefits. Similarly, whereas non-users emphasised the negative aspects of excessive concern with beauty, sunbed users challenged and distanced themselves from this negativity. Sunbed users were engaged in a form of identity-work to protect themselves from the wider negativity and disapproval of which they were aware. Conclusion Theoretically, social representations theory has provided a unique lens through which to explore this topic, highlighting the importance of taking into consideration the wider environment in which sunbed use takes place. Preliminary practical suggestions include that health workers should consider identity-work when designing interventions aimed at reducing sunbed use. Findings also suggest that, rather than continuing to educate sunbed users about the risks, campaigns and interventions should challenge the commonly drawn upon arguments about the health benefits. These benefits emerged as a particularly powerful discursive tool for the sunbed users in helping to justify their behaviour, but also to counteract negative stereotypes and assumptions they knew others held of them

Knowledge Systems and Risk Management: Threat Lessons Learned from COVID-19 in 2020-21

The year 2020-21 has shown us that the likelihood of extreme events is greater than we would have expected. When organizational resources are stretched to their limits due to extreme events, they are also more vulnerable to cyber-attacks and knowledge risks. Based on the events that took place during the 2020-21 period, we identify five knowledge risks and categorize them as technical, behavioral, and legal risks. We identify possible controls to mitigate these knowledge risks: proper knowledge identification, guidelines for employee knowledge behavior, identification and evaluation of online communication channels, and risk re-assessment to knowledge