11 research outputs found
Absorption Behavior of Acid Gases in Protic Ionic Liquid/Alkanolamine Binary Mixtures
Herein,
we studied the absorption of H<sub>2</sub>S and CO<sub>2</sub> by
alkanolamineâprotic ionic liquids binary mixtures
based on 2-hydroxyethylammonium (MEA) or triethanolammonium cations
and residues of 2-hydroxy-5-sulfobenzoic acid or pyridine-3-carboxylic
acid at various temperatures and partial gases pressures. It was found
that absorbents based on the 2-hydroxyethylammonium cation, performed
high absorption properties toward the H<sub>2</sub>S. The solubility
of hydrogen sulfide, characterized by the Henryâs Law constant,
in MEA-based binary mixtures had the values comparable to the commercially
available ionic liquids. The results of thermal desorption analysis
demonstrated that the capture of acid gases in MEA-based absorbents
occurred at two stages: through the dissolution in MEA component and
in protic ionic liquid
Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow
The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions
Synthesis of Chlorin-(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development
A series of multifunctional conjugates each consisting of a fluorescent chlorin photosensitizer and an (arylamino)quinazoline-based epidermal growth factor receptor/vascular endothelial growth factor receptor ligand, potentially useful in site-selective photodynamic antitumor therapy, were prepared and their photochemical properties were investigated
Decatungstateâmediated C(sp3)âH Heteroarylation via RadicalâPolar Crossover in Batch and Flow
Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp(3))âH functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with the oxidative radicalâpolar crossover concept to access the direct netâoxidative C(sp(3))âH heteroarylation. The present methodology demonstrates a high functional group tolerance (40 examples) and is scalable when using continuousâflow reactor technology. The developed protocol is also amenable to the lateâstage functionalization of biologically relevant molecules such as stanozolol, (â)âambroxide, podophyllotoxin, and dideoxyribose
Decatungstate-Mediated C(sp3)âH Heteroarylation via Radical-Polar Crossover in Batch and Flow
 Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)âH functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with the oxidative radicalâpolar crossover concept to access the direct net-oxidative C(sp3)âH heteroarylation. The present methodology demonstrates a high functional group tolerance (40 examples) and is scalable when using continuous-flow reactor technology. The developed protocol is also amenable to the late-stage functionalization of biologically relevant molecules such as stanozolol, (â)-ambroxide, podophyllotoxin, and dideoxyribose. </p
The Cation Effect on the Free Volume and the Solubility of H<sub>2</sub>S and CO<sub>2</sub> in Ionic Liquids Based on Bis(2-Ethylhexyl) Sulfosuccinate Anion
Herein, we report for the first time a study dedicated to acidic gasesâ solubility in ionic liquids with sterically hindered bulky anion, namely bis(2-ethylhexyl) sulfosuccinate ([doc]), experimentally evaluated at low pressures. The effect of cation change (imidazolium, pyridinium, and pyrrolidinium) on the thermophysical properties and sorption capacities was also discussed. The densities and the activation energies of the tested ILs exhibited minor differences. Furthermore, the COSMO-RS model was used to predict the free volumes of ILs aiming to investigate its influence on gas solubilities. The conducted calculations have revealed an antibate correlation between the fractional free volume (FFV) and Henryâs law constant. In particular, the lowest FFV in 1-methylimidazolium [doc] corresponded to the minimal sorption and vice versa. In addition, it was shown that the presence of protic cation results in a significant reduction in CO2 and H2S solubilities. In general, the solubility measurement results of the synthesized ILs have shown their superiority compared to fluorinated ILs based on the physical absorption mechanism
A First-in-Class ÎČ-Glucuronidase Responsive Conjugate for Selective Dual Targeted and Photodynamic Therapy of Bladder Cancer
In this report, we present a novel prodrug strategy that can significantly improve the efficiency and selectivity of combined therapy for bladder cancer. Our approach involved the synthesis of a conjugate based on a chlorin-e6 photosensitizer and a derivative of the tyrosine kinase inhibitor cabozantinib, linked by a ÎČ-glucuronidase-responsive linker. Upon activation by ÎČ-glucuronidase, which is overproduced in various tumors and localized in lysosomes, this conjugate released both therapeutic modules within targeted cells. This activation was accompanied by the recovery of its fluorescence and the generation of reactive oxygen species. Investigation of photodynamic and dark toxicity in vitro revealed that the novel conjugate had an excellent safety profile and was able to inhibit tumor cells proliferation at submicromolar concentrations. Additionally, combined therapy effects were also observed in 3D models of tumor growth, demonstrating synergistic suppression through the activation of both photodynamic and targeted therapy
Decatungstate-Mediated C(sp3)âH Heteroarylation via Radical-Polar Crossover in Batch and Flow
 Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)âH functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with the oxidative radicalâpolar crossover concept to access the direct net-oxidative C(sp3)âH heteroarylation. The present methodology demonstrates a high functional group tolerance (40 examples) and is scalable when using continuous-flow reactor technology. The developed protocol is also amenable to the late-stage functionalization of biologically relevant molecules such as stanozolol, (â)-ambroxide, podophyllotoxin, and dideoxyribose. </p
Supplementary data for the paper: Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow
The dataset contains characterization of compounds obtained via trifluoromethoxylation processes under photochemical conditions