ВЛИЯНИЕ ФАКТОРА НЕСТАБИЛЬНОСТИ ВНЕШНЕЙ СРЕДЫ НА СТРАТЕГИЮ ВЗАИМОДЕЙСТВИЯ ГОСУДАРСТВА И БИЗНЕСА В ВЫСОКОТЕХНОЛОГИЧНЫХ СФЕРАХ РОССИЙСКОЙ ЭКОНОМИКИ

The types of the unstable state of the macroeconomic environment affecting the strategy of forming government and business. Applied to high-tech industries studied forms of public-private partnerships. The structure of the organizational problems that arise in the creation and development of effective public-private partnership whose solution minimizes the negative effects of environmental factors.Рассмотрены виды нестабильного состояния макроэкономической среды, влияющие на формирование стратегии развития государства и бизнеса. Применительно к высокотехнологичным отраслям экономики исследованыформыгосударственно-частногопартнерства. Предложенаструктураорганизационныхзадач, возникающихвсфересозданияи эффективногоразвитиягосударственно-частногопартнерства, решение которыхминимизируетдействиенегативныхфактороввнешнейсред

Rapid Optimization of Metal Nanoparticle Surface Modification with High-Throughput Gel Electrophoresis

The ability to effectively control and optimize surface modification of metal nanoparticles is paramount to the ability to employ metal nanoparticles as diagnostic and therapeutic agents in biology and medicine. Here we present a high-throughput two-dimensional-grid gel electrophoresis cell (2D-GEC)-based method, capable of optimizing the surface modification of as many as 96 samples of metal nanoparticles in approximately 1 h. The 2D-GEC method determines not only the average zeta-potential of the modified particles but also the homogeneity of the surface modification by measuring the distance between the front of the sample track and the area where the maximum optical density is achieved. The method was tested for optimizing pH and concentration of the modifiers (pM) for functionalizing gold nanorod thiol-containing acidic agents