6 research outputs found
Molecular Logic with a Saccharide Probe on the Few-Molecules Level
In this Communication we describe a two-component saccharide
probe
with logic capability. The combination of a boronic acid-appended
viologen and perylene diimide was able to perform a complementary
implication/not implication logic function. Fluorescence quenching
and recovery with fructose was analyzed with fluorescence correlation
spectroscopy on the level of a few molecules of the reporting dye
Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via <sup>19</sup>F NMR Barcodes
Fluorinated boronic acid-appended
benzyl bipyridinium salts, derived
from 4,4ā²-, 3,4ā²-, and 3,3ā²-bipyridines, were
synthesized and used to detect and differentiate diol-containing analytes
at physiological conditions via <sup>19</sup>F NMR spectroscopy. An
array of three water-soluble boronic acid receptors in combination
with <sup>19</sup>F NMR spectroscopy discriminates nine diol-containing
bioanalytesīøcatechol, dopamine, fructose, glucose, glucose-1-phosphate,
glucose-6-phosphate, galactose, lactose, and sucroseīøat low
mM concentrations. Characteristic <sup>19</sup>F NMR fingerprints
are interpreted as two-dimensional barcodes without the need of multivariate
analysis techniques
Red Light-Triggered CO Release from Mn<sub>2</sub>(CO)<sub>10</sub> Using Triplet Sensitization in Polymer Nonwoven Fabrics
Applicability
of phototherapeutic CO-releasing molecules (photoCORMs)
is limited because they are activated by harmful and poorly tissue-penetrating
near-ultraviolet light. Here, a strategy is demonstrated to activate
classical photoCORM Mn<sub>2</sub>(CO)<sub>10</sub> using red light
(635 nm). By mixing in solution a triplet photosensitizer (<b>PS</b>) with the photoCORM and shining red light, energy transfer occurs
from triplet excited-state <sup>3</sup><b>PS</b>* to a photolabile
triplet state of Mn<sub>2</sub>(CO)<sub>10</sub>, which, like under
near-UV irradiation, led to complete release of carbonyls. Crucially,
such ātriplet-sensitized CO-releaseā occurred in solid-state
materials: when <b>PS</b> and Mn<sub>2</sub>(CO)<sub>10</sub> were embedded in electrospun nonwoven fabrics, CO was liberated
upon irradiation with low-intensity red light (ā¤36 mW 635 nm)
Fluorinated Boronic Acid-Appended Pyridinium Salts and <sup>19</sup>F NMR Spectroscopy for Diol Sensing
The
identification and discrimination of diols is of fundamental importance
in medical diagnostics, such as measuring the contents of glucose
in the urine of diabetes patients. Diol sensors are often based on
fluorophore-appended boronic acids, but these severely lack discriminatory
power and their response is one-dimensional. As an alternative strategy,
we present the use of fluorinated boronic acid-appended pyridinium
salts in combination with <sup>19</sup>F NMR spectroscopy. A pool
of 59 (bio)Āanalytes was screened, containing monosaccharides, phosphorylated
and <i>N</i>-acetylated sugars, polyols, carboxylic acids,
nucleotides, and amines. The majority of analytes could be clearly
detected and discriminated. In addition, glucose and fructose could
be distinguished up to 1:9 molar ratio in mixtures. Crucially, the
receptors feature high sensitivity and selectivity and are water-soluble,
and their <sup>19</sup>F-NMR analyte fingerprint is pH-robust, thereby
making them particularly well-suited for medical application. Finally,
to demonstrate this applicability, glucose could be detected in synthetic
urine samples down to 1 mM using merely a 188 MHz NMR spectrometer
Fluorinated Boronic Acid-Appended Pyridinium Salts and <sup>19</sup>F NMR Spectroscopy for Diol Sensing
The
identification and discrimination of diols is of fundamental importance
in medical diagnostics, such as measuring the contents of glucose
in the urine of diabetes patients. Diol sensors are often based on
fluorophore-appended boronic acids, but these severely lack discriminatory
power and their response is one-dimensional. As an alternative strategy,
we present the use of fluorinated boronic acid-appended pyridinium
salts in combination with <sup>19</sup>F NMR spectroscopy. A pool
of 59 (bio)Āanalytes was screened, containing monosaccharides, phosphorylated
and <i>N</i>-acetylated sugars, polyols, carboxylic acids,
nucleotides, and amines. The majority of analytes could be clearly
detected and discriminated. In addition, glucose and fructose could
be distinguished up to 1:9 molar ratio in mixtures. Crucially, the
receptors feature high sensitivity and selectivity and are water-soluble,
and their <sup>19</sup>F-NMR analyte fingerprint is pH-robust, thereby
making them particularly well-suited for medical application. Finally,
to demonstrate this applicability, glucose could be detected in synthetic
urine samples down to 1 mM using merely a 188 MHz NMR spectrometer