Impact of changing relations upon the duration of an obligation

<p>Eligibility and enrollment of TB cases included at sites that enrolled prospectively.</p

Participant characteristics at retrospective sites, KwaZulu-Natal Province, South Africa (n = 403).

<p>Participant characteristics at retrospective sites, KwaZulu-Natal Province, South Africa (n = 403).</p

Study sites and risk classifications.

<p>Classifications of areas in KwaZulu-Natal Province, South Africa, as high or low risk for rifampicin resistant TB based on Lot Quality Assurance Sampling and GeneXpert testing. Areas in dark blue were included in the study. <i>Modified from "Map of South Africa with district borders (2011)" (author</i>: <i>Htonl) under a CC Attribution-Share Alike 3</i>.<i>0 Unported license</i>, <i>with permission from Wikimedia Commons</i>, <i>original copyright 2011</i>. <i>Available</i>: <a href="https://commons.wikimedia.org/wiki/File:Map_of_South_Africa_with_district_borders_(2011).svg" target="_blank">https://commons.wikimedia.org/wiki/File:Map_of_South_Africa_with_district_borders_(2011).svg</a></p

Operating characteristic curve for a sample size of 82 and decision rule of 4.

<p>The operating characteristic curve demonstrates that a sample size of 82 new TB cases and a decision cut-off of 4 achieves the desired misclassification properties (<10% misclassifications at a true prevalence of resistance of 8% and at a true prevalence of resistance of 2%).</p

LQAS classifications: prospective sites (n = 164).

<p>LQAS classifications: prospective sites (n = 164).</p

LQAS classifications: retrospective sites (n = 403).

<p>LQAS classifications: retrospective sites (n = 403).</p

MGIT liquid culture drug-susceptibility testing (DST) results for patients identified as RIF-R by GeneXpert.

<p>(Bold font denotes MDR).</p

Line listing of samples with discordance between GeneXpert and MGIT liquid culture for detection of TB.

<p>Line listing of samples with discordance between GeneXpert and MGIT liquid culture for detection of TB.</p

Participant characteristics at prospective sites, KwaZulu-Natal Province, South Africa (n = 164).

<p>Participant characteristics at prospective sites, KwaZulu-Natal Province, South Africa (n = 164).</p

Characterisation of the Phage 1 clone identified using HTP Illumina sequencing.

<p>Phage 1 was amplified and 5×10¹¹, 1×10¹²phages (x-axis) were used for a plate binding assay with (A) <i>M. tb</i> H37Rv, (B) (Δleu/Δpan) <i>M. tb</i>, (C) <i>BCG</i> and (D) <i>M. smegmatis</i> as solid-phase antigens. The unselected library was used as a control. A two-tailed, unpaired t-test was used to analyse significance (**<i>p</i><0.01). Error bars represent standard deviations of the arithmetic means of the normalised optical densities at 405 nm performed in triplicates.</p