4,124 research outputs found
Review of \u3cem\u3eDiverging Pathways: Social Structure and Career Deflections.\u3c/em\u3e Alan C. Kerkckhoff. Reviewed by Karl L. Alexander, Johns Hopkins University.
Alan C. Kerckhoff. Diverging Pathways: Social Structure and Career Deflections. Cambridge University Press, 1993. $49.95 hardcover
Non-Pharmacological Therapy for Atrial Fibrillation: Managing the Left Atrial Appendage
The prevalence of atrial fibrillation (AF) is increasing in parallel with an ageing population leading to increased morbidity and mortality. The most feared complication of AF is stroke, with the arrhythmia being responsible for up to 20% of all ischemic strokes. An important contributor to this increased risk of stroke is the left atrial appendage (LAA). A combination of the LAA's unique geometry and atrial fibrillation leads to low blood flow velocity and stasis, which are precursors to thrombus formation. It has been hypothesized for over half a century that excision of the LAA would lead to a reduction in the incidence of stroke. It has only been in the last 20–25 years that the knowledge and technology has been available to safely carry out such a procedure. We now have a number of viable techniques, both surgical and percutaneous, which will be covered in this paper
Burning Both Ends: Examining Overload, Trait Motivation, and Burnout Through the Person-Environment Interaction
Burnout has received substantial attention in academic literature and popular media due to its extensive breadth and detrimental impact on individual and organizational outcomes. To effectively address and combat the phenomenon, it is important to understand the boundary conditions in which burnout occurs and the individual and environmental interactions that predict burnout. In the current study, the relationships among burnout, overload, and trait motivation were investigated. Data were collected via Amazon Mechanical Turk from a sample of working professionals. Overload was negatively related to approach motivation and positively related to avoidance motivation and burnout. Approach motivation was negatively related to burnout, while avoidance motivation was positively related. A series of moderation models were tested to understand the interaction between trait motivation and overload in the relationship to burnout. The moderation results were not confirmed, but the main effects were significant. Understanding relevant boundary conditions and individual differences associated with motivation and burnout will equip organizational leaders and decision-makers to effectively combat the phenomenon and preserve employee well-being
The First Stage of Cardinal Direction Selectivity Is Localized to the Dendrites of Retinal Ganglion Cells
SummaryInferring the direction of image motion is a fundamental component of visual computation and essential for visually guided behavior. In the retina, the direction of image motion is computed in four cardinal directions, but it is not known at which circuit location along the flow of visual information the cardinal direction selectivity first appears. We recorded the concerted activity of the neuronal circuit elements of single direction-selective (DS) retinal ganglion cells at subcellular resolution by combining GCaMP3-functionalized transsynaptic viral tracing and two-photon imaging. While the visually evoked activity of the dendritic segments of the DS cells were direction selective, direction-selective activity was absent in the axon terminals of bipolar cells. Furthermore, the glutamate input to DS cells, recorded using a genetically encoded glutamate sensor, also lacked direction selectivity. Therefore, the first stage in which extraction of a cardinal motion direction occurs is the dendrites of DS cells
Generation of GeV protons from 1 PW laser interaction with near critical density targets
The propagation of ultra intense laser pulses through matter is connected
with the generation of strong moving magnetic fields in the propagation channel
as well as the formation of a thin ion filament along the axis of the channel.
Upon exiting the plasma the magnetic field displaces the electrons at the back
of the target, generating a quasistatic electric field that accelerates and
collimates ions from the filament. Two-dimensional Particle-in-Cell simulations
show that a 1 PW laser pulse tightly focused on a near-critical density target
is able to accelerate protons up to an energy of 1.3 GeV. Scaling laws and
optimal conditions for proton acceleration are established considering the
energy depletion of the laser pulse.Comment: 26 pages, 8 figure
Brain-Inspired Computational Intelligence via Predictive Coding
Artificial intelligence (AI) is rapidly becoming one of the key technologies
of this century. The majority of results in AI thus far have been achieved
using deep neural networks trained with the error backpropagation learning
algorithm. However, the ubiquitous adoption of this approach has highlighted
some important limitations such as substantial computational cost, difficulty
in quantifying uncertainty, lack of robustness, unreliability, and biological
implausibility. It is possible that addressing these limitations may require
schemes that are inspired and guided by neuroscience theories. One such theory,
called predictive coding (PC), has shown promising performance in machine
intelligence tasks, exhibiting exciting properties that make it potentially
valuable for the machine learning community: PC can model information
processing in different brain areas, can be used in cognitive control and
robotics, and has a solid mathematical grounding in variational inference,
offering a powerful inversion scheme for a specific class of continuous-state
generative models. With the hope of foregrounding research in this direction,
we survey the literature that has contributed to this perspective, highlighting
the many ways that PC might play a role in the future of machine learning and
computational intelligence at large.Comment: 37 Pages, 9 Figure
Fine Structure in the Circumstellar Environment of a Young, Solar-like Star: the Unique Eclipses of KH 15D
Results of an international campaign to photometrically monitor the unique
pre-main sequence eclipsing object KH 15D are reported. An updated ephemeris
for the eclipse is derived that incorporates a slightly revised period of 48.36
d. There is some evidence that the orbital period is actually twice that value,
with two eclipses occurring per cycle. The extraordinary depth (~3.5 mag) and
duration (~18 days) of the eclipse indicate that it is caused by circumstellar
matter, presumably the inner portion of a disk. The eclipse has continued to
lengthen with time and the central brightness reversals are not as extreme as
they once were. V-R and V-I colors indicate that the system is slightly bluer
near minimum light. Ingress and egress are remarkably well modeled by the
passage of a knife-edge across a limb-darkened star. Possible models for the
system are briefly discussed.Comment: 19 pages, 5 figure
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