26 research outputs found
Π€ΡΠ½ΠΊΡΠΈΡ ΠΊΡΡΠΏΠ½ΡΡ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΏΡΠΈ ΠΏΡΠΎΡΠΈΠ°Π·Π΅ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΈ ΠΈΠ·Π±ΡΡΠΎΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΎΠΉ ΡΠ΅Π»Π° Π½Π° ΡΠΎΠ½Π΅ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°ΡΠΎΠΌ
Background. In recent years, the opinion has been established that skin manifestations of psoriasis are associated with the damage of other organs and systems, and that psoriatic lesions have a systemic nature, and therefore the term βpsoriatic diseaseβ is increasingly used in scientific literature. Among psoriasis comorbidities, metabolic disorders and cardiovascular diseases are of particular clinical importance. Our aim was to study the effect of systemic cytostatic therapy with methotrexate on the remodelling processes of large vessels in children with psoriasis who have normal and increased body mass index. Methods. The primary data was collected by extracting data from medical records and case follow-up records. The subsequent accumulation, storage, grouping and primary sorting of research data were carried out using a personal computer and Excel application package. Clinical evaluation of the severity of psoriasis and skin lesions was assessed by calculating the PASI index. Non-invasive oscillometric arteriography was performed on a portable ArterioGraph (TensioMed Ltd, Hungary). Results. A direct significant correlation has been established between the revealed impairments of the function of large arteries and the indicators of fat metabolism, the severity of psoriasis and body mass index. During the systemic pathogenetic cytostatic therapy with methotrexate, a significant positive dynamics of the function parameters of large arteries was revealed in children with psoriasis who have both normal and increased body mass index. Conclusion. The undertaken studies showed that methotrexate is an effective and safe agent for treating psoriasis in children aged from 3 to 18 years, has a positive effect on the function of large vessels.Nikolay N. Murashkin β receiving research funding from pharmaceutical companies Jansen, Eli Lilly. Receiving fees for scientific advice from Galderma, Pierre Fabre, Bayer, Astellas, Libriderm.Alexander I. Materikin β receiving research funding from pharmaceutical company Eli Lilly. Receiving fees for scientific advice from Bioderma, Libriderm.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅. Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΡΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΎΡΡ ΠΌΠ½Π΅Π½ΠΈΠ΅ ΠΎΠ± Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΊΠΎΠΆΠ½ΡΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ ΠΏΡΠΎΡΠΈΠ°Π·Π° Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π΄ΡΡΠ³ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΈΡΡΠ΅ΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΡΡΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΏΡΠΈ ΠΏΡΠΎΡΠΈΠ°Π·Π΅, Π² ΡΠ²ΡΠ·ΠΈ Ρ ΡΠ΅ΠΌ Π² Π½Π°ΡΡΠ½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ Π²ΡΠ΅ ΡΠ°ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ ΡΠ΅ΡΠΌΠΈΠ½ Β«ΠΏΡΠΎΡΠΈΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π±ΠΎΠ»Π΅Π·Π½ΡΒ». Π‘ΡΠ΅Π΄ΠΈ ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΡ
ΠΏΡΠΎΡΠΈΠ°Π·Ρ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ ΠΎΡΠΎΠ±ΠΎΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅ΡΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΈ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ²Π°ΡΠΊΡΠ»ΡΡΠ½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°ΡΠΎΠΌ Π½Π° ΠΏΡΠΎΡΠ΅ΡΡΡ ΡΠ΅ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΡΠΏΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ² ΠΏΡΠΈ ΠΏΡΠΎΡΠΈΠ°Π·Π΅ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠΌ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. ΠΠ΅ΡΠΎΠ΄Ρ. Π‘Π±ΠΎΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΡΡ ΠΏΡΡΠ΅ΠΌ Π²ΡΠΊΠΎΠΏΠΈΡΠΎΠ²ΠΊΠΈ Π΄Π°Π½Π½ΡΡ
ΠΈΠ· ΠΈΡΡΠΎΡΠΈΠΉ Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ ΠΈ ΠΊΠ°ΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ. ΠΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅, Ρ
ΡΠ°Π½Π΅Π½ΠΈΠ΅, Π³ΡΡΠΏΠΏΠΈΡΠΎΠ²ΠΊΠ° ΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΠΎΡΡΠΈΡΠΎΠ²ΠΊΠ° Π΄Π°Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ° ΠΈ ΠΏΠ°ΠΊΠ΅ΡΠ° ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΡΡ
ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ Excel. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΠΆΠ΅ΡΡΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ°Π·Π° ΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΠΎΠ²Π° ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»Π°ΡΡ ΠΏΡΡΠ΅ΠΌ ΠΏΠΎΠ΄ΡΡΠ΅ΡΠ° ΠΈΠ½Π΄Π΅ΠΊΡΠ° PASI. ΠΠ΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½Π°Ρ ΠΎΡΡΠΈΠ»Π»ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΡΡΠ΅ΡΠΈΠΎΠ³ΡΠ°ΡΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ Π½Π° ΠΏΠΎΡΡΠ°ΡΠΈΠ²Π½ΠΎΠΌ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ΅ ArterioGraph (TensioMed Ltd, ΠΠ΅Π½Π³ΡΠΈΡ). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΏΡΡΠΌΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΊΡΡΠΏΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΠΉ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΆΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, ΡΡΠΆΠ΅ΡΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ°Π·Π° ΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. ΠΠ° ΡΠΎΠ½Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°ΡΠΎΠΌ Π²ΡΡΠ²Π»Π΅Π½Π° Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΡΠ½ΠΊΡΠΈΠΉ ΠΊΡΡΠΏΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΠΉ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΏΡΠΎΡΠΈΠ°Π·ΠΎΠΌ ΠΊΠ°ΠΊ Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠΌ, ΡΠ°ΠΊ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΌΠ΅ΡΠΎΡΡΠ΅ΠΊΡΠ°Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΡΠΌ ΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΎΡΠΈΠ°Π·Π° Ρ Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 3 Π΄ΠΎ 18 Π»Π΅Ρ, ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΡΠ½ΠΊΡΠΈΠΈ ΠΊΡΡΠΏΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ².Π.Π. ΠΡΡΠ°ΡΠΊΠΈΠ½ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Jansen, Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Galderma, Pierre Fabre, Bayer, Astellas, Libriderm.Π.Π. ΠΠ°ΡΠ΅ΡΠΈΠΊΠΈΠ½ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Bioderma, Libriderm
ΠΠΎΠΏΡΠΎΡΡ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠ΅Π»Π΅Π½ΠΎΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ Π² ΡΠ²Π΅ΡΠ΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΎ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
Diaper dermatitis is a disease belonging to the group of contact dermatitis. Clinical manifestations include skin inflammation in the area of contact with the diaper due to barrier epidermal dysfunction. The paper analyses the pathogenesis of the disease and presents data on a local clinical study on the safety and efficacy of the medication with a regenerative potential.ΠΠ΅Π»Π΅Π½ΠΎΡΠ½ΡΠΉ Π΄Π΅ΡΠΌΠ°ΡΠΈΡ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠΈΡ ΠΊ Π³ΡΡΠΏΠΏΠ΅ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ½ΡΡ
Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠΎΠ² ΠΈ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΆΠΈ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ° Ρ ΠΏΠΎΠ΄Π³ΡΠ·Π½ΠΈΠΊΠΎΠΌ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ Π±Π°ΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ. Π ΡΡΠ°ΡΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π· Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Ρ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ.ΠΠΎΠ½ΡΠ»ΠΈΠΊΡ ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ²Π.Π. ΠΡΡΠ°ΡΠΊΠΈΠ½ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Jansen, Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Galderma, Pierre Fabre, Bayer, ΠΠΠ Β«ΠΠ΅Π»Π΄ΠΈΡ-Π€Π°ΡΠΌΠ°Β». Π.Π‘. ΠΡΡΠ³Π»ΠΎΠ²Π° β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Galderma, Bayer, Astellas, Libriderm, ΠΠΠ Β«ΠΠ΅Π»Π΄ΠΈΡ-Π€Π°ΡΠΌΠ°Β». Π.Π. ΠΠ°ΡΠ΅ΡΠΈΠΊΠΈΠ½, Π.Π’. ΠΠΌΠ±Π°ΡΡΡΠ½ Π .Π. ΠΠΏΠΈΡΠ΅Π² β ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ»ΠΈΠΊΡΠ° ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ², ΠΎ ΠΊΠΎΡΠΎΡΠΎΠΌ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΠΎΠΎΠ±ΡΠΈΡΡ
ΠΠ½Π½ΠΎΠ²Π°ΡΠΈΠΈ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ°, ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ³ΠΎ Π²ΡΠΎΡΠΈΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ
Reduced skin barrier properties in patients with atopic dermatitis (AtD) are largely caused by microbiome changes and extensive Staphylococcus aureus colonisation of the skin. In this regard, the integument of patients with AtD requires constant care and the use of various emollients. The inclusion of lysates of non-pathogenic microorganisms and prebiotics in the composition of emollients ensures the normalisation of the microbiome composition and the immunological barrier of the skin. The article presents the results of our own observations on the application of two cosmetic scin-care products for damaged skin with vitamin F in children with AtD complicated by a secondary infection, while the composition of one of the products is additionally enriched with ceramides and prebiotics. The safety and high efficacy of both products have been shown, however, the presence of ceramides and prebiotics in the emollient composition makes it possible to achieve a marked decrease in the degree of S. aureus colonisation of the skin.Π‘Π½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π±Π°ΡΡΠ΅ΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΠΎΠ²Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠΎΠΌ (ΠΡΠ) Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΌ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠΌΠ° ΠΈ ΠΎΠ±ΡΠΈΡΠ½ΠΎΠΉ ΠΊΠΎΠ»ΠΎΠ½ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ ΠΊΠΎΠΆΠΈ Staphylococcus aureus. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π½Π°ΡΡΠΆΠ½ΡΠΉ ΠΏΠΎΠΊΡΠΎΠ² Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΡΠ ΡΡΠ΅Π±ΡΠ΅Ρ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎΠ³ΠΎ ΡΡ
ΠΎΠ΄Π° ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠΌΠΎΠ»Π΅Π½ΡΠΎΠ². ΠΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π² ΡΠΎΡΡΠ°Π² ΡΠΌΠΎΠ»Π΅Π½ΡΠΎΠ² Π»ΠΈΠ·Π°ΡΠΎΠ² Π½Π΅ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠ² ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΠΎΡΡΠ°Π²Π° ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠΌΠ° ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π±Π°ΡΡΠ΅ΡΠ° ΠΊΠΎΠΆΠΈ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΉ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΡΠ, ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΌ Π²ΡΠΎΡΠΈΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ, Π΄Π²ΡΡ
ΠΊΠΎΡΠΌΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΏΠΎ ΡΡ
ΠΎΠ΄Ρ Π·Π° ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΊΠΎΠΆΠ΅ΠΉ Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠΌ F, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠΎΡΡΠ°Π² ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· Π½ΠΈΡ
Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΎΠ±ΠΎΠ³Π°ΡΠ΅Π½ ΡΠ΅ΡΠ°ΠΌΠΈΠ΄Π°ΠΌΠΈ ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΈ Π²ΡΡΠΎΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠ±ΠΎΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΠΎΠ΄Π½Π°ΠΊΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π² ΡΠΎΡΡΠ°Π²Π΅ ΡΠΌΠΎΠ»Π΅Π½ΡΠ° ΡΠ΅ΡΠ°ΠΌΠΈΠ΄ΠΎΠ² ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΠ±ΠΈΠ²Π°ΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΊΠΎΠ»ΠΎΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΠΎΠ²Π° S. aureus.ΠΠΠΠ€ΠΠΠΠ’ ΠΠΠ’ΠΠ ΠΠ‘ΠΠΠ. Π. ΠΡΡΠ°ΡΠΊΠΈΠ½ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Jansen, Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Galderma, Pierre Fabre, Bayer, Astellas, Libriderm.Π. Π. ΠΠ°ΡΠ΅ΡΠΈΠΊΠΈΠ½ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Bioderma, Libriderm.Π. Π’. ΠΠΌΠ±Π°ΡΡΡΠ½ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Jansen, Libriderm.Π . Π. ΠΠΏΠΈΡΠ΅Π² β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
Π³ΡΠ°Π½ΡΠΎΠ² ΠΎΡ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Eli Lilly. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠ½ΠΎΡΠ°ΡΠΎΠ² Π·Π° Π½Π°ΡΡΠ½ΠΎΠ΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Jansen, Libriderm.Π. Π. Π€ΡΠ΄ΠΎΡΠΎΠ² ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ» ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ»ΠΈΠΊΡΠ° ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ², ΠΎ ΠΊΠΎΡΠΎΡΠΎΠΌ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΠΎΠΎΠ±ΡΠΈΡ
Observational study of pimecrolimus 1% cream for prevention of transcutaneous sensitization in children with atopic dermatitis during their first year of life
IntroductionEpidermal barrier dysfunction in children with atopic dermatitis can cause transcutaneous sensitization to allergens and allergic diseases. We evaluated the effectiveness of an early-intervention algorithm for atopic dermatitis treatment, utilizing pimecrolimus for long-term maintenance therapy, in reducing transcutaneous sensitization in infants.MethodThis was a single-center cohort observational study that enrolled children aged 1-4 months with family history of allergic diseases, moderate-to-severe atopic dermatitis, and sensitization to β₯ 1 of the investigated allergens. Patients who sought medical attention at atopic dermatitis onset (within 10 days) were group 1 βbaseline therapy with topical glucocorticoids with subsequent transition to pimecrolimus as maintenance therapyβ; patients who sought medical attention later were group 2 βbaseline and maintenance therapy with topical glucocorticoids, without subsequent use of pimecrolimusβ. Sensitization class and level of allergen-specific immunoglobulin E were determined at baseline, and 6 and 12 months of age. Atopic dermatitis severity was evaluated using the Eczema Area and Severity Index score at baseline and 6, 9 and 12 months of age.ResultsFifty-six and 52 patients were enrolled in groups 1 and 2, respectively. Compared with group 2, group 1 demonstrated a lower level of sensitization to cow's milk protein, egg white and house dust mite allergen at 6 and 12 months of age, and a more pronounced decrease in atopic dermatitis severity at 6, 9 and 12 months of age. No adverse events occurred.DiscussionThe pimecrolimus-containing algorithm was effective in treating atopic dermatitis and prophylaxis of early forms of allergic diseases in infants.Trial registrationhttps://clinicaltrials.gov/NCT04900948, retrospectively registered, 25 May 2021
The Function of Large Vessels in Normal-Weight and Overweight Children With Psoriasis During Methotrexate Therapy
Background. In recent years, the opinion has been established that skin manifestations of psoriasis are associated with the damage of other organs and systems, and that psoriatic lesions have a systemic nature, and therefore the term βpsoriatic diseaseβ is increasingly used in scientific literature. Among psoriasis comorbidities, metabolic disorders and cardiovascular diseases are of particular clinical importance. Our aim was to study the effect of systemic cytostatic therapy with methotrexate on the remodelling processes of large vessels in children with psoriasis who have normal and increased body mass index. Methods. The primary data was collected by extracting data from medical records and case follow-up records. The subsequent accumulation, storage, grouping and primary sorting of research data were carried out using a personal computer and Excel application package. Clinical evaluation of the severity of psoriasis and skin lesions was assessed by calculating the PASI index. Non-invasive oscillometric arteriography was performed on a portable ArterioGraph (TensioMed Ltd, Hungary). Results. A direct significant correlation has been established between the revealed impairments of the function of large arteries and the indicators of fat metabolism, the severity of psoriasis and body mass index. During the systemic pathogenetic cytostatic therapy with methotrexate, a significant positive dynamics of the function parameters of large arteries was revealed in children with psoriasis who have both normal and increased body mass index. Conclusion. The undertaken studies showed that methotrexate is an effective and safe agent for treating psoriasis in children aged from 3 to 18 years, has a positive effect on the function of large vessels.Nikolay N. Murashkin β receiving research funding from pharmaceutical companies Jansen, Eli Lilly. Receiving fees for scientific advice from Galderma, Pierre Fabre, Bayer, Astellas, Libriderm.Alexander I. Materikin β receiving research funding from pharmaceutical company Eli Lilly. Receiving fees for scientific advice from Bioderma, Libriderm
THE ROLE OF EPIDERMAL BARRIER IMPAIRMENTS IN ATOPIC DERMATITIS: MODERN CONCEPTS OF DISEASE PATHOGENESIS
Atopic dermatitis is a common chronic inflammatory skin disease characterized by a recurring course and progressive decrease in the quality of life. Recent studies in this area demonstrate the multifaceted pathogenesis of atopic dermatitis. Interaction of such factors as epidermal dysfunction, immune system disorders, and the consequences of genetic mutations contributes not only to the development of the disease but also to its progression and chronic course. The article presents various components of the etiopathogenesis of atopic dermatitis, describes the role of lipids, thereby the new therapeutic targets are revealed to specialists
Contemporary View of the Structural and Functional Peculiarities of the Skin, Items of Care and Prevention of Dermatological Pathology in Infants
The article presents the modern knowledge of the structural and functional peculiarities of the skin in children. Information on the etiopathogenesis of a debut atopic dermatitis has been also given. The results of our own observations with an analysis of the clinical efficacy and safety of cosmetics based on highly purified lanolin and cotton extract in infants have been presented
Problems of Prevention and Treatment of Diaper Dermatitis in Children within the Current Concepts of the Disease Pathogenesis
Diaper dermatitis is a disease belonging to the group of contact dermatitis. Clinical manifestations include skin inflammation in the area of contact with the diaper due to barrier epidermal dysfunction. The paper analyses the pathogenesis of the disease and presents data on a local clinical study on the safety and efficacy of the medication with a regenerative potential
Innovations in the Therapy of Atopic Dermatitis Complicated by a Secondary Infection
Reduced skin barrier properties in patients with atopic dermatitis (AtD) are largely caused by microbiome changes and extensive Staphylococcus aureus colonisation of the skin. In this regard, the integument of patients with AtD requires constant care and the use of various emollients. The inclusion of lysates of non-pathogenic microorganisms and prebiotics in the composition of emollients ensures the normalisation of the microbiome composition and the immunological barrier of the skin. The article presents the results of our own observations on the application of two cosmetic scin-care products for damaged skin with vitamin F in children with AtD complicated by a secondary infection, while the composition of one of the products is additionally enriched with ceramides and prebiotics. The safety and high efficacy of both products have been shown, however, the presence of ceramides and prebiotics in the emollient composition makes it possible to achieve a marked decrease in the degree of S. aureus colonisation of the skin
Features and Basic Approaches to Pyoderma Topical Treatment in Children
Pyodermas are the most frequent reason for visiting dermatologists among children. The immunity to development of pyodermas is based on skin barrier the part of which is cutaneous microbiome. The microbiome composition is unique and depends on age, localization on various body regions, environment. The change of its qualitative and quantitative composition leads to the development of purulent dermal diseases characterized by clinical diversity and severe course and development of complications (without adequate treatment). In this regard the choice of the correct therapy remains relevant. The results of studies covering the effectiveness of various topic antibacterial agents are analysed. Practical aspects of pyodermia therapy in children using local therapy are illustrated