On the Acquisition of Prepositions*

This work studies the acquisition of Greek Prepositional Phrases. We focus on locative prepositions, because they may combine a lexical and a functional element, hence, can offer insights for both the acquisition and the syntactic status of prepositions from this perspective. We found that both, se and apo, appear after the lexical part of complex prepositions, and fully develop after age three. We compare se and apo when part of complex prepositions and when conveying location/direction alone and conclude that the former may be acquired after the latter. Apo is also encountered much earlier alone, but only preceding locative adverbials

Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland

Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospholipids in adrenocortical cells. Inhibition of the rate-limiting enzyme of PUFA synthesis, fatty acid desaturase 2 (FADS2), leads to perturbations in the mitochondrial lipidome and diminishes steroidogenesis. Consistently, the adrenocortical mitochondria of Fads2$^{-/-}$ mice fed a diet with low PUFA concentration are structurally impaired and corticoid levels are decreased. On the contrary, FADS2 expression is elevated in the adrenal cortex of obese mice, and plasma corticosterone is increased, which can be counteracted by dietary supplementation with the FADS2 inhibitor SC-26192 or icosapent ethyl, an eicosapentaenoic acid ethyl ester. In humans, FADS2 expression is elevated in aldosterone-producing adenomas compared to non-active adenomas or nontumorous adrenocortical tissue and correlates with expression of steroidogenic genes. Our data demonstrate that FADS2-mediated PUFA synthesis determines adrenocortical steroidogenesis in health and disease

On the acquisition of prepositions

This work studies the acquisition of Greek Prepositional Phrases. We focus on locative prepositions, because they may combine a lexical and a functional element, hence, can offer insights for both the acquisition and the syntactic status of prepositions from this perspective. We found that both, se and apo, appear after the lexical part of complex prepositions, and fully develop after age three. We compare se and apo when part of complex prepositions and when conveying location/direction alone and conclude that the former may be acquired after the latter. Apo is also encountered much earlier alone, but only preceding locative adverbial

Necrotizing fasciitis in a 68-year old patient with insulin-treated steroid diabetes

A 68-year old man was admitted to our department with left arm erythema, pain, and swelling after injecting insulin isophane. LRINEC score, CT, and MRI imaging diagnosed necrotizing fasciitis. With surgical debridement, tight glycemic control and treatment, the patient was discharged 13 days later. Keywords: Necrotizing, Fasciitis, Diabetes, Methicillin, Resistant, Staphylococcu