Photometry Results for the Globular Clusters M10 and M12: Extinction Maps, Color-Magnitude Diagrams, and Variable Star Candidates

We report on photometry results of the equatorial globular clusters (GCs) M10 and M12. These two clusters are part of our sample of GCs which we are probing for the existence of photometrically varying eclipsing binary stars. During the search for binaries in M10 and M12, we discovered the signature of differential reddening across the fields of the clusters. The effect is stronger for M10 than for M12. Using our previously described dereddening technique, we create differential extinction maps for the clusters which dramatically improve the appearance of the color-magnitude diagrams (CMDs). Comparison of our maps with the dust emissivity maps of Schlegel, Finkbeiner, & Davis (SFD) shows good agreement in terms of spatial extinction features. Several methods of adding an E_{V-I} zero point to our differential maps are presented of which isochrone fitting proved to be the most successful. Our E_{V-I} values fall within the range of widely varying literature values. More specifically, our reddening zero point estimate for M12 agrees well with the SFD estimate, whereas the one for M10 falls below the SFD value. Our search for variable stars in the clusters produced a total of five variables: three in M10 and two in M12. The M10 variables include a binary system of the W Ursa Majoris (W UMa) type, a background RR Lyrae star, and an SX Phoenicis pulsator, none of which is physically associated with M10. M12's variables are two W UMa binaries, one of which is most likely a member of the cluster. We present the phased photometry lightcurves for the variable stars, estimate their distances, and show their locations in the fields and the CMDs of the GCs.Comment: 22 pages, 21 figures, to be published in AJ October 2002. For a higher-resolution version of this paper, please visit http://www.astro.lsa.umich.edu/~kaspar/M10_M12_photometry.ps.gz (gzipped postscript) or http://www.astro.lsa.umich.edu/~kaspar/M10_M12_photometry.pdf (pdf file

Counting Statistics of an Adiabatic Pump

We consider quantum statistics of charge transmitted through a mesoscopic device in the adiabatic pumping process. A general formula for the distribution function of the transmitted charge in terms of the time-dependent S-matrix is obtained. It is applied to a few simple examples of the pumping cycles. We identify coherent pumping strategies which lead to the binomial charge distribution and minimize the fluctuations of the pumped current. Conditions for the ideal noiseless quantized pump are discussed.Comment: 4 page

Band Formation during Gaseous Diffusion in Aerogels

We study experimentally how gaseous HCl and NH_3 diffuse from opposite sides of and react in silica aerogel rods with porosity of 92 % and average pore size of about 50 nm. The reaction leads to solid NH_4Cl, which is deposited in thin sheet-like structures. We present a numerical study of the phenomenon. Due to the difference in boundary conditions between this system and those usually studied, we find the sheet-like structures in the aerogel to differ significantly from older studies. The influence of random nucleation centers and inhomogeneities in the aerogel is studied numerically.Comment: 7 pages RevTex and 8 figures. Figs. 4-8 in Postscript, Figs. 1-3 on request from author

Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial.

BackgroundAdjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides a modest survival benefit. Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to platinum-based chemotherapy in advanced-stage non-squamous NSCLC. We aimed to evaluate the addition of bevacizumab to adjuvant chemotherapy in early-stage resected NSCLC.MethodsWe did an open-label, randomised, phase 3 trial of adult patients (aged ≥18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1 and who had completely resected stage IB (≥4 cm) to IIIA (defined by the American Joint Committee on Cancer 6th edition) NSCLC. We enrolled patients from across the US National Clinical Trials Network, including patients from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) affiliates in Europe and from the Canadian Cancer Trials Group, within 6-12 weeks of surgery. The chemotherapy regimen for each patient was selected before randomisation and administered intravenously; it consisted of four 21-day cycles of cisplatin (75 mg/m2 on day 1 in all regimens) in combination with investigator's choice of vinorelbine (30 mg/m2 on days 1 and 8), docetaxel (75 mg/m2 on day 1), gemcitabine (1200 mg/m2 on days 1 and 8), or pemetrexed (500 mg/m2 on day 1). Patients in the bevacizumab group received bevacizumab 15 mg/kg intravenously every 21 days starting with cycle 1 of chemotherapy and continuing for 1 year. We randomly allocated patients (1:1) to group A (chemotherapy alone) or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by chemotherapy regimen, stage of disease, histology, and sex. No one was masked to treatment assignment, except the Data Safety and Monitoring Committee. The primary endpoint was overall survival, analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00324805.FindingsBetween June 1, 2007, and Sept 20, 2013, 1501 patients were enrolled and randomly assigned to the two treatment groups: 749 to group A (chemotherapy alone) and 752 to group B (chemotherapy plus bevacizumab). 383 (26%) of 1458 patients (with complete staging information) had stage IB, 636 (44%) had stage II, and 439 (30%) had stage IIIA disease (stage of disease data were missing for 43 patients). Squamous cell histology was reported for 422 (28%) of 1501 patients. All four cisplatin-based chemotherapy regimens were used: 377 (25%) patients received vinorelbine, 343 (23%) received docetaxel, 283 (19%) received gemcitabine, and 497 (33%) received pemetrexed. At a median follow-up of 50·3 months (IQR 32·9-68·0), the estimated median overall survival in group A has not been reached, and in group B was 85·8 months (95% CI 74·9 to not reached); hazard ratio (group B vs group A) 0·99 (95% CI 0·82-1·19; p=0·90). Grade 3-5 toxicities of note (all attributions) that were reported more frequently in group B (the bevacizumab group) than in group A (chemotherapy alone) were overall worst grade (ie, all grade 3-5 toxicities; 496 [67%] of 738 in group A vs 610 [83%] of 735 in group B), hypertension (60 [8%] vs 219 [30%]), and neutropenia (241 [33%] vs 275 [37%]). The number of deaths on treatment did not differ between the groups (15 deaths in group A vs 19 in group B). Of these deaths, three in group A and ten in group B were considered at least possibly related to treatment.InterpretationAddition of bevacizumab to adjuvant chemotherapy did not improve overall survival for patients with surgically resected early-stage NSCLC. Bevacizumab does not have a role in this setting and should not be considered as an adjuvant therapy for patients with resected early-stage NSCLC.FundingNational Cancer Institute of the National Institutes of Health

Torsion pairs and simple-minded systems in triangulated categories

Let T be a Hom-finite triangulated Krull-Schmidt category over a field k. Inspired by a definition of Koenig and Liu, we say that a family S of pairwise orthogonal objects in T with trivial endomorphism rings is a simple-minded system if its closure under extensions is all of T. We construct torsion pairs in T associated to any subset X of a simple-minded system S, and use these to define left and right mutations of S relative to X. When T has a Serre functor \nu, and S and X are invariant under \nu[1], we show that these mutations are again simple-minded systems. We are particularly interested in the case where T is the stable module category of a self-injective algebra \Lambda. In this case, our mutation procedure parallels that introduced by Koenig and Yang for simple-minded collections in the derived category of \Lambda. It follows that the mutation of the set of simple \Lambda-modules relative to X yields the images of the simple \Gamma-modules under a stable equivalence between \Gamma\ and \Lambda, where \Gamma\ is the tilting mutation of \Lambda\ relative to X.Comment: Minor corrections. To appear in Applied Categorical Structures. The final publication is available at springerlink.com: http://link.springer.com/article/10.1007%2Fs10485-014-9365-

Design and performance of the multiplexing spectrometer CAMEA

The cold neutron multiplexing secondary spectrometer CAMEA (Continuous Angle Multiple Energy Analysis) was commissioned at the Swiss spallation neutron source SINQ at the Paul Scherrer Institut at the end of 2018. The spectrometer is optimised for an efficient data collection in the horizontal scattering plane, allowing for detailed and rapid mapping of excitations under extreme conditions. The novel design consists of consecutive, upward scattering analyzer arcs underneath an array of position sensitive detectors mounted inside a low permeability stainless-steel vacuum vessel. The construction of the world's first continuous angle multiple energy analysis instrument required novel solutions to many technical challenges, including analyzer mounting, vacuum connectors, and instrument movement. These were solved by extensive prototype experiments and in-house developments. Here we present a technical overview of the spectrometer describing in detail the engineering solutions and present our first experimental data taken during the commissioning. Our results demonstrate the tremendous gains in data collection rate for this novel type of spectrometer design

О становлении трансплантологии в Украине: юридические аспекты

Рассмотрены основные аспекты развития трансплантологии, их положительное и отрицательное влияние на прогресс пересадки органов в странах с различным уровнем развития демократических принципов. Показано значение юридических проблем в развитии клинической и экспериментальной трансплантологии.Main aspects of transplantology development, their favorable and unfavorable influence on the process of organ transplantation in the countries with different level of democracy are featured. Significance of legal problems in clinical and experimental transplantology is shown