7 research outputs found
The genetic architecture of type 2 diabetes
- Author
- Abboud Hanna E.
- Abecasis Goncalo
- Afzal Uzma
- Agarwala Vineeta
- Aguilar David
- Altshuler David
- Arya Rector
- Atzmon Gil
- Aung Tin
- Balkau Beverley
- Banks Eric
- Barroso Ines
- Barzilai Nir
- Beer Nicola L.
- Bell Graeme I.
- Below Jennifer E.
- Bergman Richard N.
- Bharadwaj Dwaipayan
- Blackwell Thomas W.
- Blancher Christine
- Blangero John
- Boehnke Michael
- Boeing Heiner
- Bonnycastle Lori L.
- Bork-Jensen Jette
- Bottinger Erwin P.
- Bowden Donald W.
- Brandslund Ivan
- Buck David
- Buck Gemma
- Burtt Noël P.
- Butterworth Adam S.
- Carey Jason
- Carneiro Mauricio O.
- Chambers John C.
- Chan Edmund
- Chan Juliana C.N.
- Chandak Giriraj R.
- Chen Han
- Chen Peng
- Chen Yuhui
- Cheng Ching-Yu
- Chia Kee Seng
- Chines Peter S.
- Cho Yoon Shin
- Christensen Cramer
- Cingolani Pablo
- Collins Francis S.
- Correa Adolfo
- Cox Nancy J.
- Curran Joanne E.
- Daly Mark J.
- Danesh John
- Day-Williams Aaron G.
- De Angelis Martin Hrabé
- DeFronzo Ralph A.
- Deloukas Panos
- DePristo Mark
- Doney Alex S.F.
- Donnelly Peter
- Duggirala Ravindranath
- Dupuis Josee
- Ebrahim Shah B.
- Elliott Paul
- Esko Tonu
- Fadista Joao
- Farjoun Yossi
- Farmer Andrew J.
- Farook Vidya S.
- Fennell Timothy
- Ferreira Teresa
- Fingerlin Tasha
- Flannick Jason
- Florez Jose C.
- Fontanillas Pierre
- Fowler Sharon P.
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Froguel Philippe
- Fuchsberger Christian
- Gabriel Stacey
- Gamazon Eric R.
- Gaulton Kyle J.
- Giedraitis Vilmantas
- Gieger Christian
- Gjesing Anette P.
- Glaser Benjamin
- Gloyn Anna L.
- Go Min Jin
- Gottesman Omri
- Grallert Harald
- Grant George
- Grarup Niels
- Green Todd
- Griswold Michael
- Groop Leif
- Groves Christopher J.
- Hakaste Liisa
- Hale Daniel Esten
- Han Bok-Ghee
- Hanis Craig L.
- Hansen Torben
- Hartl Christopher
- Hattersley Andrew T.
- Herder Christian
- Hicks Pamela J.
- Highland Heather M.
- Hodgkiss Dylan
- Hollensted Mette
- Horikoshi Momoko
- Howson Joanna M.M.
- Hu Cheng
- Hu Frank B.
- Huang Jinyan
- Huh Iksoo
- Huth Cornelia
- Huyghe Jeroen R.
- Ikram Mohammad Kamran
- Illig Thomas
- Im Hae Kyung
- Ingelsson Erik
- Isomaa Bo
- Jablonski Kathleen A.
- Jackson Anne U.
- Jenkinson Christopher P.
- Jia Weiping
- Jorgensen Marit E.
- Jorgensen Torben
- Jun Goo
- Justesen Johanne Marie
- Kang Hyun Min
- Karpe Fredrik
- Khor Chiea-Chuen
- Kim Bong-Jo
- Kim Yongkang
- Kim Young Jin
- Kinnunen Leena
- Koistinen Heikki A.
- Kooner Jaspal Singh
- Kravic Jasmina
- Kriebel Jennifer
- Kumar Ashish
- Kumar Satish
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kwak Soo-Heon
- Kwan Phoenix
- Kwon Min-Seok
- Käräjämäki Annemari
- Laakso Markku
- Ladenvall Claes
- Lam Vincent K.L.
- Lander Eric S.
- Langenberg Claudia
- Lannfelt Lars
- Lauritzen Torsten
- Lee Heung Man
- Lee Jaehoon
- Lee Jong-Young
- Lee Juyoung
- Lee Selyeong
- Lehman Donna M.
- Lehne Benjamin
- Levy Jonathan C.
- Liang Liming
- Lim Wei Yen
- Lin Keng-Han
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Jianjun
- Locke Adam E.
- Loh Marie
- Loos Ruth J.F.
- Lu Yingchang
- Lyssenko Valeriya
- Ma Clement
- Ma Ronald C.W.
- Maguire Jared
- Mahajan Anubha
- Mangino Massimo
- Manning Alisa
- Maxwell Taylor J.
- McCarthy Davis J.
- McCarthy Mark I.
- McVean Gilean
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Mohlke Karen L.
- Morris Andrew D.
- Morris Andrew P.
- Moutsianas Loukas
- Murphy Jacquelyn
- Musani Solomon K.
- Mägi Reedik
- Müller-Nurasyid Martina
- Nagai Yoshihiko
- Narisu Narisu
- Navarro Carmen
- Neale Benjamin M.
- Neville Matt
- Ng Maggie C.Y.
- Nilsson Peter
- Njolstad Pal Rasmus
- O'Rahilly Stephen P.
- Onofrio Robert
- Orho-Melander Marju
- Owen Katharine R.
- Palli Domenico
- Palmer Colin N.A.
- Palmer Nicholette D.
- Park Kyong Soo
- Park Taesung
- Parker Stephen C.J.
- Pasko Dorota
- Pearson Richard D.
- Pedersen Oluf
- Perry John R.B.
- Peters Annette
- Pollin Toni I.
- Poplin Ryan
- Prabhakaran Dorairaj
- Prokopenko Inga
- Puppala Sobha
- Purcell Shaun
- Qi Lu
- Qi Qibin
- Rathmann Wolfgang
- Rauramaa Rainer
- Rayner N. William
- Ried Janina S.
- Rivas Manuel A.
- Robertson Neil R.
- Roden Michael
- Rolandsson Olov
- Rosengren Anders H.
- Rybin Denis
- Saleheen Danish
- Salomaa Veikko
- Sandhu Manjinder
- Schwarzmayr Thomas
- Scott James
- Scott Laura J.
- Scott Robert A.
- Scott William R.
- Seielstad Mark
- Shakir Khalid
- Sim Xueling
- Sladek Rob
- Small Kerrin S.
- Smith Joshua D.
- So Wing Yee
- Spector Timothy D.
- Stančáková Alena
- Stirrups Kathleen
- Stitzel Michael L.
- Strauch Konstantin
- Stringham Heather M.
- Strom Tim M.
- Surdulescu Gabriela L.
- Swift Amy
- Syvänen Ann-Christine
- Tai E. Shyong
- Tajes Juan Fernandez
- Tam Claudia H.T.
- Tan Sian-Tsung
- Tandon Nikhil
- Taylor Herman A.
- Teo Yik Ying
- Teslovich Tanya M.
- Thameem Farook
- Thorand Barbara
- Thuillier Dorothée
- Trakalo Joseph
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Van De Bunt Martijn
- Van Der Schouw Yvonne T.
- Varga Tibor V.
- Voight Benjamin F.
- Walker Mark
- Wang Xu
- Wareham Nicholas J.
- Watanabe Richard M.
- Welch Ryan P.
- Wieland Thomas
- Wilson Gregory
- Wilson James G.
- Wong Tien Yin
- Wood Andrew R.
- Yengo Loic
- Yoon Joon
- Zeggini Eleftheria
- Zhang Weihua
- Zhao Wei
- Publication venue
- Publication date
- 01/01/2016
- Field of study
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes
Diagnosis of Gastric Cancer by Serum Proteomic Fingerprinting
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Congenital Intrathoracic Stomach: Short Esophagus or Hiatal Hernia?
- Author
- Publication venue
- 'S. Karger AG'
- Publication date
- Field of study
Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register
- Author
- Aimin Yang
- Alex C.W. Ng
- Alice P. Kong
- Alicia J. Jenkins
- Anandwardhan A. Hardikar
- Andrea O. Luk
- Anthony C. Keech
- Baoqi Fan
- Cadmon K.P. Lim
- Cheung
- Claudia H.T. Tam
- Elaine Chow
- Eric S.H. Lau
- Feifei Cheng
- Harte
- Heung Man Lee
- Hongjiang Wu
- Jahangiry
- Joglekar
- Juliana C.N. Chan
- Jylhävä
- Masi
- Mugdha V. Joglekar
- Ronald C.W. Ma
- Spigoni
- Tamura
- Wang
- Wing Yee So
- Wu
- Publication venue
- 'American Diabetes Association'
- Publication date
- Field of study
The genetic architecture of type 2 diabetes
- Author
- Abboud Hanna E.
- Abecasis Goncalo
- Afzal Uzma
- Agarwala Vineeta
- Aguilar David
- Altshuler David
- Arya Rector
- Atzmon Gil
- Aung Tin
- Balkau Beverley
- Banks Eric
- Barroso Ines
- Barzilai Nir
- Beer Nicola L.
- Bell Graeme I.
- Below Jennifer E.
- Bergman Richard N.
- Bharadwaj Dwaipayan
- Blackwell Thomas W.
- Blancher Christine
- Blangero John
- Boehnke Michael
- Boeing Heiner
- Bonnycastle Lori L.
- Bork-Jensen Jette
- Bottinger Erwin P.
- Bowden Donald W.
- Brandslund Ivan
- Buck David
- Buck Gemma
- Burtt Noël P.
- Butterworth Adam S.
- Carey Jason
- Carneiro Mauricio O.
- Chambers John C.
- Chan Edmund
- Chan Juliana C.N.
- Chandak Giriraj R.
- Chen Han
- Chen Peng
- Chen Yuhui
- Cheng Ching Yu
- Chia Kee Seng
- Chines Peter S.
- Cho Yoon Shin
- Christensen Cramer
- Cingolani Pablo
- Collins Francis S.
- Correa Adolfo
- Cox Nancy J.
- Curran Joanne E.
- Daly Mark J.
- Danesh John
- Day-Williams Aaron G.
- De Angelis Martin Hrabé
- DeFronzo Ralph A.
- Deloukas Panos
- DePristo Mark
- Doney Alex S.F.
- Donnelly Peter
- Duggirala Ravindranath
- Dupuis Josee
- Ebrahim Shah B.
- Elliott Paul
- Esko Tonu
- Fadista Joao
- Farjoun Yossi
- Farmer Andrew J.
- Farook Vidya S.
- Fennell Timothy
- Ferreira Teresa
- Fingerlin Tasha
- Flannick Jason
- Florez Jose C.
- Fontanillas Pierre
- Fowler Sharon P.
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Froguel Philippe
- Fuchsberger Christian
- Gabriel Stacey
- Gamazon Eric R.
- Gaulton Kyle J.
- Giedraitis Vilmantas
- Gieger Christian
- Gjesing Anette P.
- Glaser Benjamin
- Gloyn Anna L.
- Go Min Jin
- Gottesman Omri
- Grallert Harald
- Grant George
- Grarup Niels
- Green Todd
- Griswold Michael
- Groop Leif
- Groves Christopher J.
- Hakaste Liisa
- Hale Daniel Esten
- Han Bok Ghee
- Hanis Craig L.
- Hansen Torben
- Hartl Christopher
- Hattersley Andrew T.
- Herder Christian
- Hicks Pamela J.
- Highland Heather M.
- Hodgkiss Dylan
- Hollensted Mette
- Horikoshi Momoko
- Howson Joanna M.M.
- Hu Cheng
- Hu Frank B.
- Huang Jinyan
- Huh Iksoo
- Huth Cornelia
- Huyghe Jeroen R.
- Ikram Mohammad Kamran
- Illig Thomas
- Im Hae Kyung
- Ingelsson Erik
- Isomaa Bo
- Jablonski Kathleen A.
- Jackson Anne U.
- Jenkinson Christopher P.
- Jia Weiping
- Jorgensen Marit E.
- Jorgensen Torben
- Jun Goo
- Justesen Johanne Marie
- Kang Hyun Min
- Karpe Fredrik
- Khor Chiea Chuen
- Kim Bong Jo
- Kim Yongkang
- Kim Young Jin
- Kinnunen Leena
- Koistinen Heikki A.
- Kooner Jaspal Singh
- Kravic Jasmina
- Kriebel Jennifer
- Kumar Ashish
- Kumar Satish
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kwak Soo Heon
- Kwan Phoenix
- Kwon Min Seok
- Käräjämäki Annemari
- Laakso Markku
- Ladenvall Claes
- Lam Vincent K.L.
- Lander Eric S.
- Langenberg Claudia
- Lannfelt Lars
- Lauritzen Torsten
- Lee Heung Man
- Lee Jaehoon
- Lee Jong Young
- Lee Juyoung
- Lee Selyeong
- Lehman Donna M.
- Lehne Benjamin
- Levy Jonathan C.
- Liang Liming
- Lim Wei Yen
- Lin Keng Han
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Jianjun
- Locke Adam E.
- Loh Marie
- Loos Ruth J.F.
- Lu Yingchang
- Lyssenko Valeriya
- Ma Clement
- Ma Ronald C.W.
- Maguire Jared
- Mahajan Anubha
- Mangino Massimo
- Manning Alisa
- Maxwell Taylor J.
- McCarthy Davis J.
- McCarthy Mark I.
- McVean Gilean
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Mohlke Karen L.
- Morris Andrew D.
- Morris Andrew P.
- Moutsianas Loukas
- Murphy Jacquelyn
- Musani Solomon K.
- Mägi Reedik
- Müller-Nurasyid Martina
- Nagai Yoshihiko
- Narisu Narisu
- Navarro Carmen
- Neale Benjamin M.
- Neville Matt
- Ng Maggie C.Y.
- Nilsson Peter
- Njolstad Pal Rasmus
- O'Rahilly Stephen P.
- Onofrio Robert
- Orho-Melander Marju
- Owen Katharine R.
- Palli Domenico
- Palmer Colin N.A.
- Palmer Nicholette D.
- Park Kyong Soo
- Park Taesung
- Parker Stephen C.J.
- Pasko Dorota
- Pearson Richard D.
- Pedersen Oluf
- Perry John R.B.
- Peters Annette
- Pollin Toni I.
- Poplin Ryan
- Prabhakaran Dorairaj
- Prokopenko Inga
- Puppala Sobha
- Purcell Shaun
- Qi Lu
- Qi Qibin
- Rathmann Wolfgang
- Rauramaa Rainer
- Rayner N. William
- Ried Janina S.
- Rivas Manuel A.
- Robertson Neil R.
- Roden Michael
- Rolandsson Olov
- Rosengren Anders H.
- Rybin Denis
- Saleheen Danish
- Salomaa Veikko
- Sandhu Manjinder
- Schwarzmayr Thomas
- Scott James
- Scott Laura J.
- Scott Robert A.
- Scott William R.
- Seielstad Mark
- Shakir Khalid
- Sim Xueling
- Sladek Rob
- Small Kerrin S.
- Smith Joshua D.
- So Wing Yee
- Spector Timothy D.
- Stančáková Alena
- Stirrups Kathleen
- Stitzel Michael L.
- Strauch Konstantin
- Stringham Heather M.
- Strom Tim M.
- Surdulescu Gabriela L.
- Swift Amy
- Syvänen Ann Christine
- Tai E. Shyong
- Tajes Juan Fernandez
- Tam Claudia H.T.
- Tan Sian Tsung
- Tandon Nikhil
- Taylor Herman A.
- Teo Yik Ying
- Teslovich Tanya M.
- Thameem Farook
- Thorand Barbara
- Thuillier Dorothée
- Trakalo Joseph
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Van De Bunt Martijn
- Van Der Schouw Yvonne T.
- Varga Tibor V.
- Voight Benjamin F.
- Walker Mark
- Wang Xu
- Wareham Nicholas J.
- Watanabe Richard M.
- Welch Ryan P.
- Wieland Thomas
- Wilson Gregory
- Wilson James G.
- Wong Tien Yin
- Wood Andrew R.
- Yengo Loic
- Yoon Joon
- Zeggini Eleftheria
- Zhang Weihua
- Zhao Wei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 04/08/2016
- Field of study
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- António Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecile Yelnik
- Cedric Laouenan
- Ceila Sant'Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chloe Donohue
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
- Claire Lévy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Clotilde Allavena
- Clément Le Bihan
- Colin McArthur
- Coline Jaud-Fischer
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cédric Joseph
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Dafsah Juzar
- Damien Bouhour
- Daniel Glikman
- Daniel Haber
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- David L. Robertson
- David Maslove
- David Richardson
- David S.Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Debby Bogaert
- Deepashankari Suppiah
- Dehbia Benkerrou
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana Adrião
- Diana Hernández
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Fernando Rincon
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dyah Kanya Wati
- Dzawani Muhamad
- Eder Caceres
- Edmund Manning
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elise Artaud-Macari
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Ema Leal
- Eman Al Qasim
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L'her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
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- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
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- Abel Lynn
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease