Role of the Recoil Ion in Single-Electron Capture and Single-Ionization Processes for Collisions of Protons with He and Ar Atoms

In this work the single-electron capture and single-ionization processes are studied for proton collisions with He and Ar atoms at impact energies in the range 25–100 keV. Classical trajectory Monte Carlo simulations are benchmarked against experimental data obtained at the reaction microscope in Bariloche, Argentina, which employs the cold target recoil-ion momentum spectroscopy technique. Special emphasis is placed on describing the momentum transfer to the recoil ion for these collision systems

Postnatal Development of ACTH and a-MSH in the Medulla Oblongata of Rat: c -MSH Is the Predominant Peptide

development of ACTH and a-MSH in the medulla oblongata of rat: a-MSH i.s the predominant peptide. PE PTIDES 6: Suppl. 2, 137-141, 1985.-ACTH and a-MSH levels were measured by radioimmunoassays in extracts of the caudal medulla oblongata of developing rats on postnatal (P) days 1-42 at 7 day intervals, and in adult rats. From PI to adulthood, ACTH increased > ! 1-fold from 7.2_ + 1.9 fmol to 82.4_+ 12.6 fmol per medulla section (mean_+ S.E.M.). In comparison, a-MSH increased >7-fold from 68.75_+ 11.0 fmol to 491 _+97.8 fmol during this time period. ACTH/p.g of soluble protein decreased during postnatal development from 0.006_+0.01 to 0.005_+0.001 fmol//zg of protein and a-MSH increased from 0.06_+0.01 fmol//zg of protein to 0.11 -+0.009 fmol//xg of protein between P1 and P7, decreased to 0.015_+0.003 fmol/#g of protein by P42 and increased to 0.03-+0.006 fmol/protein per unit protein by adulthood. These data indicate a significant shift in the levels of a-MSH detected during development with a decrease in the concentration of material occurring from early postnatal development (P1-P7) to adulthood, which does not appear to be solely related to a regional increase in protein. These studies, as well as radioimmunoassays for ACTH and a-MSH in combination with sizing chromatography of pooled extracts at P1. P7 and the adult, demonstrated the predominance of a-MSH at all ages

Successful intravenous immunoglobulin treatment for steroid-resistant eosinophilic enteritis in a patient with systemic lupus erythematosus.

Eosinophilic gastroenteritis is a rare condition of unknown etiology characterized by eosinophilic infiltration of the bowel. Corticosteroids are the mainstay of EG therapy. Although rare, steroid-resistant EG could be a life-threatening condition with tissue destructive evolution. Associations of eosinophilic gastroenteritis with systemic lupus erythematosus have rarely been reported. In this report we describe a case of successful IVIG treatment in a patient with systemic lupus erythematosus and steroid-refractory eosinophilic gastroenteritis

Supercritical Antisolvent Precipitation of Quercetin Systems: Preliminary Experiments

Flavonoids have attracted a lot of attention due to their antioxidant, antitumor and antibacterial activities. Quercetin (3,5,7,3,4-pentahydroxyflavone) is a polyphenolic flavonoid that shows several biological effects including a strong inhibitory effect on the growth of several human and animal cancer cell lines and enhances the antiproliferative effect of cisplatin both in-vitro and in-vivo. In spite of a variety of its biological effects. Quercetin is very poorly soluble in water, which has limited its absorption upon oral administration. As known, the solubility of drug is often due to the increase of the surface/volume ratio which implies the increase of the number of surface atoms (or molecules) with respect to the number of bulk atoms (or molecules). With this aim, we investigated the use of supercritical antisolvent (SAS) technique for Quercetin microparticles generation finding the best operative conditions through the Peng Robinson’s Equation of State. The obtained simulation behaviors were confirmed by experimental precipitation: the physicochemical characterizations of the samples were also performe

Supercritical Antisolvent Precipitation of Quercetin Systems: Preliminary Experiments

Flavonoids have attracted a lot of attention due to their antioxidant, antitumor and antibacterial activities. Quercetin (3,5,7,3,4-pentahydroxyflavone) is a polyphenolic flavonoid that shows several biological effects including a strong inhibitory effect on the growth of several human and animal cancer cell lines and enhances the antiproliferative effect of cisplatin both in-vitro and in-vivo. In spite of a variety of its biological effects. Quercetin is very poorly soluble in water, which has limited its absorption upon oral administration. As known, the solubility of drug is often due to the increase of the surface/volume ratio which implies the increase of the number of surface atoms (or molecules) with respect to the number of bulk atoms (or molecules). With this aim, we investigated the use of supercritical antisolvent (SAS) technique for Quercetin microparticles generation finding the best operative conditions through the Peng Robinson’s Equation of State. The obtained simulation behaviors were confirmed by experimental precipitation: the physicochemical characterizations of the samples were also performe

Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis C.

Eosinophilic infiltrate of liver tissue is described in primary cholestatic diseases, hepatic allograft rejection and drug-induced liver injury, but its significance and its implications in chronic hepatitis C are unknown. The aim of this study was to investigate the clinical significance of eosinophilic liver infiltrate in patients with chronic hepatitis C. We retrospectively evaluated 147 patients with chronic hepatitis C. The presence of eosinophilic infiltrate was investigated in liver biopsies, and a numeric count of eosinophilic leucocytes in every portal tract was assessed. An eosinophilic infiltrate of liver tissue (≥3 cells evaluated in the portal/periportal spaces) was observed in 46 patients (31%), and patients who consumed drugs had an odds ratio (OR) of 4.02 (95% CI: 1.62-9.96) to have an eosinophilic infiltrate in liver biopsy. By logistic regression analysis, the presence of steatosis was independently associated with eosinophilic infiltrate (OR 5.86; 95% CI: 2.46-13.96) and homeostasis model assessment-score (OR 1.18; 95% CI: 1.00-1.39). Logistic regression analysis also showed that fibrosis staging ≥ 2 by Scheuer score was associated with grading >1 by Scheuer score (OR 6.82; 95% CI 2.46-18.80) and eosinophilic infiltrate (OR 4.00; 95% CI 1.23-12.91). In conclusion, we observed that the eosinophilic infiltrate of liver tissue was significantly more frequent in patients who assumed drugs, and found a significant association between eosinophilic infiltrate, liver steatosis and liver fibrosis. These preliminary data could lead to a constant assumption of drugs as a co-factor of eosinophils-mediated liver injury in chronic hepatitis