Comparisons Between Modeling and Measured Performance of the BNL Linac

Quite good agreement has been achieved between computer modeling and actual performance of the Brookhaven 200 MeV Linac. We will present comparisons between calculated and measured performance for the beam transport through the RFQ, the 6 meter transport from RFQ to the linac and meching and transport through the linac.Comment: 3 page

A Super-Conducting Linac Driver for the HFBR

This paper reports on the feasibility study of a proton Super-Conducting Linac (SCL) as a driver gor the High-Flux Breader Reactor (HFBR) at Brookhaven National Laboratory (BNL). The Linac operates in Continuos Wave (CW) mode to produce an average 10 MW of beam power. The Linac energy is 1.0 GeV. The average proton beam intensity is 10 mA.Comment: 3 page

The NSNS High Energy Beam Transport Line

In the National Spallation Neutron Source (NSNS) design, a 180 meter long transport line connects the 1 GeV linac to an accumulator ring. The linac beam has a current of 28 mA, pulse length of 1 ms, and 60 Hz rep rate. The high energy transport line consists of sixteen 60 degrees FODO cells, and accommodates a 90 degrees achromatic bend, an energy compressor, collimators, part of injection system, and enough diagnostic devices to measure the beam quality before injection. To reduce the uncontrolled beam losses, this line has nine beam halo scrapers and very tight tolerances on both transverse and longitudinal beam dynamics under space charge conditions. The design of this line is presented.Comment: 3 pages, transfer line desig

The relevance of point defects in studying silica-based materials from bulk to nanosystems

The macroscopic properties of silica can be modified by the presence of local microscopic modifications at the scale of the basic molecular units (point defects). Such defects can be generated during the production of glass, devices, or by the environments where the latter have to operate, impacting on the devices’ performance. For these reasons, the identification of defects, their generation processes, and the knowledge of their electrical and optical features are relevant for microelectronics and optoelectronics. The aim of this manuscript is to report some examples of how defects can be generated, how they can impact device performance, and how a defect species or a physical phenomenon that is a disadvantage in some fields can be used as an advantage in others

Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance

This is the final versionPoster presented at the 43rd Annual European Calcified Tissue Society Congress, Rome, Italy, 14 - 17 May 2016Pseudohypoaldosteronism type II (PHAII) is a hereditary disease characterized by hypertension, hypercalciuria and osteopenia. PHAII is caused by mutations in with-no-lysine kinase 1 (WNK1), WNK4, or the cullin RING ligase family members kelch-like 3 (KLHL3) or cullin 3 (CUL3). All mutations result in up-regulation of the WNK signalling pathway which activates thiazide-sensitive Na-Cl cotransporters (NCC) in renal distal tubules, leading to salt retention and hypertension in PHAII. The mechanism underlying hypercalciuria in PHAII is unknown. To better understand the mechanisms leading to osteopenia in PHAII, we used KLHL3R528H/+ knock-in mice carrying the same mutation as some PHAII patients. As expected, KLHL3R528H/+ mutants exhibited hyperkalemia, hypernatremia, renal calcium wasting and increased phosphorylation of NCC in the kidney. Furthermore, KLHL3R528H/+ mutants showed elevated serum parathyroid hormone (PTH), increased bone resorption as demonstrated by elevated urinary collagen crosslinks excretion and increased osteoclast numbers in femoral cancellous bone, and reduced distal femoral cancellous bone BMD and volume as evidenced by pQCT and μCT analysis. Analysis of the expression of proteins involved in renal calcium transport revealed elevated membrane abundance of the fully glycosylated epithelial calcium channel TRPV5, decreased TRPV6 abundance, and unchanged calbindin D28k expression in KLHL3R528H/+ mutants. In contrast to the upregulated TRPV5 protein expression, TRPV5 phosphorylation was reduced in KLHL3R528H/+ mutants, suggesting downregulated TRPV5 activity. In line with a crosstalk between NCC activity and PTH-mediated TRPV5 activation, we found by 2-photon microscopy that the PTH-mediated increase in Ca2+ uptake in mouse distal tubular mpkDCT4 cells was enhanced by the NCC blocker chlorothiazide or by knockout of NCC. Taken together, our study provides a mechanistic explanation for the hypercalciuria and bone loss found in PHAII patients: elevated NCC activity in KLHL3R528H/+ mice blocks PTH-mediated TRPV5 activation, leading to renal PTH resistance with subsequent renal Ca wasting and a counter-regulatory PTH-induced bone loss

DELAMINAZIONE INTERLAMINARE DI COMPOSITI CFRP AL VARIARE DELLE CONDIZIONI DI CURA DELLA MATRICE

In questo lavoro si è condotto uno studio sperimentale del comportamento a delaminazione interlaminare in Modo I di laminati compositi unidirezionali in fibra di carbonio e matrice epossidica (CFRP), al variare delle condizioni di cura della matrice. Tutti i sistemi analizzati hanno utilizzato lo stesso tessuto e lo stesso monomero epossidico DGEBA. Variando il processo di cura (cura termica o mediante radiazioni), gli agenti di cura (ammine o anidridi per i sistemi curati termicamente), e l’impiego di additivi tenacizzanti (es. il PES per i sistemi irradiati), è stato possibile controllare e modificare sia il grado di adesione fibra/matrice, che il grado di fragilità della matrice (monitorato attraverso il Fattore Critico di Intensificazione degli Sforzi KIC). Il lavoro quindi propone una analisi critica dei meccanismi di resistenza alla delaminazione controllati dalla tenacità della matrice e dalla resistenza dell’interfaccia fibra-matrice, mediante la determinazione delle Curve di Resistenza e dei valori di GIC di Innesco e di Propagazione ottenuti per i diversi sistemi presi in esame

Optics modification of the electron collector for the Relativistic Heavy Ion Collider Electron Beam Ion Source

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Alcohol Use Disorder in the Age of Technology: A Review of Wearable Biosensors in Alcohol Use Disorder Treatment

Biosensors enable observation and understanding of latent physiological occurrences otherwise unknown or invasively detected. Wearable biosensors monitoring physiological constructs across a wide variety of mental and physical health conditions have become an important trend in innovative research methodologies. Within substance use research, explorations of biosensor technology commonly focus on identifying physiological indicators of intoxication to increase understanding of addiction etiology and to inform treatment recommendations. In this review, we examine the state of research in this area as it pertains to treatment of alcohol use disorders specifically highlighting the gaps in our current knowledge with recommendations for future research. Annually, alcohol use disorders affect approximately 15 million individuals. A primary focus of existing wearable technology-based research among people with alcohol use disorders is identifying alcohol intoxication. A large benefit of wearable biosensors for this purpose is they provide continuous readings in a passive manner compared with the gold standard measure of blood alcohol content (BAC) traditionally measured intermittently by breathalyzer or blood draw. There are two primary means of measuring intoxication with biosensors: gait and sweat. Gait changes have been measured via smart sensors placed on the wrist, in the shoe, and mobile device sensors in smart phones. Sweat measured by transdermal biosensors detects the presence of alcohol in the blood stream correlating to BAC. Transdermal biosensors have been designed in tattoos/skin patches, shirts, and most commonly, devices worn on the ankle or wrist. Transdermal devices were initially developed to help monitor court-ordered sobriety among offenders with alcohol use disorder. These devices now prove most useful in continuously tracking consumption throughout clinical trials for behavioral treatment modalities. More recent research has started exploring the uses for physical activity trackers and physiological arousal sensors to guide behavioral interventions for relapse prevention. While research has begun to demonstrate wearable devices\u27 utility in reducing alcohol consumption among individuals aiming to cutdown on their drinking, monitoring sustained abstinence in studies exploring contingency management for alcohol use disorders, and facilitating engagement in activity-based treatment interventions, their full potential to further aid in understanding of, and treatment for, alcohol use disorders has yet to be explored