74 research outputs found
Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia, A double-blind, randomised, placebo-controlled trial
Rationale: Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone in addition to standard treatment in COVID-19 pneumonia. Methods: In this multicenter, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with Covid-19 pneumonia were randomised to receive 1 g of methylprednisolone intravenously for 3 consecutive days or placebo in addition to standard dexamethasone. The primary outcome was the duration of the patient hospitalisation, calculated as the time interval between randomisation and hospital discharge without the need of supplementary oxygen. The key secondary outcomes were survival free from invasive ventilation with orotracheal intubation and overall survival. Results: Overall, 112 of 151 (75.4%) patients in the pulse methylprednisolone arm and 111 of 150 (75.2%) in the placebo arm were discharged from hospital without oxygen within 30 days from randomisation. Median time to discharge was similar in both groups [15 days (95% confidence interval (CI), 13.0 to 17.0) and 16 days (95%CI, 13.8 to 18.2); hazard ratio (HR), 0.92; 95% CI 0.71-1.20; p=0.528]. No significant differences between pulse methylprednisolone and placebo arms were observed in terms of admission to Intensive Care Unit with orotracheal intubation or death (20.0% versus 16.1%; HR, 1.26; 95%CI, 0.74-2.16; p=0.176), or overall mortality (10.0% versus 12.2%; HR, 0.83; 95%CI, 0.42-1.64; p=0.584). Serious adverse events occurred with similar frequency in the two groups. Conclusions: Methylprenisolone pulse therapy added to dexamethasone was not of benefit in patients with COVID-19 pneumonia. Message of the study: Pulse glucocorticoid therapy is used for severe and/or life threatening immuno-inflammatory diseases. The addition of pulse glucocorticoid therapy to the standard low dose of dexamethasone scheme was not of benefit in patients with COVID-19 pneumonia
RIGENERAZIONI URBANE SOSTENIBILI E GREEN ECONOMY
La crisi epocale nella quale siamo immersi ha spostato il centro della questione ad un livello molto pi\uf9 alto.Uno dei primi, pi\uf9 importanti presupposti \ue8 che molti degli edifici, a volte interi quartieri, a volte anche vaste parti di citt\ue0, che costituiscono il patrimonio edilizio esistente non sono pi\uf9 idonei alla loro funzione
LCA codici per il design e l'architettura
Descrive gli aspetti del Life Cycle Assessment nel campo dell'architettura e del desig
UIA 2011 TOKIO
Editorial
BENESSERE ECO SOSTENIBILE -
Protocolli di Certificazione e Indicatori del Benessere per la Qualità dell'Abitare
Guida, pubblicata a cura del dipartimento Ambiente Energia e Sostenibilità - gruppi operativi Energia e Sostenibilità , rivolta agli architetti che intendono adottare nel progetto principi per lo sviluppo sostenibile, con lo scopo di salvaguardare l'ambiente, il territorio e il benessere dell'uomo
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