THE SPECIFICITY OF THE PROCESS OF STRATEGICAL PLANNING OF «RUSSIAN HIGHWAYS» STATE COMPANY

The aim of this work is to research the influence of industry’s specificity to the process of strategical planning of «Russian Highways» State Company. Methodologically researching consists in illustration of seven processes of strategic management on the example of «Russian Highways» State Company. The system of strategical planning documents of State Company was analyzed. The distinctive feature of strategical panning process of road building was discovered. It is in the necessity of consideration of federal and regional programs of social and economic development, schemes of territorial planning and other documents of spatial development of Russia in the process of planning of road building

Evaluation of the Debye temperature for iron cores in human liver ferritin and its pharmaceutical analogue Ferrum Lek using Mossbauer spectroscopy

An iron polymaltose complex Ferrum Lek used as antianemic drug and considered as a ferritin analogue and human liver ferritin were investigated in the temperature range from 295K to 90K by means of 57Fe Mossbauer spectroscopy with a high velocity resolution i.e. in 4096 channels. The Debye temperatures equal to 502K for Ferrum Lek and to 461K for human liver ferritin were determined from the temperature dependence of the center shift obtained using two different fitting procedures.Comment: 13 pages, 5 figure

THE SPECIFICITY OF THE PROCESS OF STRATEGICAL PLANNING OF «RUSSIAN HIGHWAYS» STATE COMPANY

The aim of this work is to research the influence of industry’s specificity to the process of strategical planning of «Russian Highways» State Company. Methodologically researching consists in illustration of seven processes of strategic management on the example of «Russian Highways» State Company. The system of strategical planning documents of State Company was analyzed. The distinctive feature of strategical panning process of road building was discovered. It is in the necessity of consideration of federal and regional programs of social and economic development, schemes of territorial planning and other documents of spatial development of Russia in the process of planning of road building

The Genre of a Grant Proposal in the Modern Teaching Context: Challenges and Possibilities

Nowadays attaining a grant is a criterion of success for an early-career researcher and an important indicator of effective work of a university as a research-based and corporate institution. During its thirty-year history in Russia, grants have become a traditional and even routine practice for every Russian PhD student and an early-career researcher. Like their international colleagues, Russian researchers often don’t get sufficient support from their scientific advisor and an academic writing expert. A few attempts to improve current situation have been made in a number of research universities. One of such cases is a course “Grant Writing” that has been recently implemented in the English-language writing-intensive program of the Moscow Institute of Physics and Technology. The complex aim or the paper can be explained by the multidimensional nature of a grant. After characterizing a grant proposal as an up-to-date text genre in the international and interdisciplinary context in the framework of Genre Field Analysis, we consider the full process of applying for a grant in real-life environment and classroom settings. Finally, in the lens of Critical Genre Analysis, the qualitative analysis of the introductory sections of Russian grant proposals is conducted. The modern genre theory gives the basis for using a combination of methods in our research. In the lens of Genre Field Analysis, the sociopragmatic approach to the grant proposal provides an opportunity to get acquainted with the modern practices of applying for a grant, while Critical Genre Analysis may contribute to the deeper understanding of the text production mechanisms. The synthesis of theory and practice and its role could be seen in the qualitative analysis of grant proposals written by PhD students, attendees of the course “Grant Writing” at the Moscow Institute of Physics and Technology. The findings give evidence for insufficient disciplinary expertise and substitution of one genre – a grant proposal – by another one, more familiar for Russian students, – a research paper and an abstract. The obtained results testify in favor of the implementation of the course “Grant Writing” as well as other genre-based courses deeply rooted in the cross-disciplinary context and aimed at developing the researcher competence

Comparative study of nanosized iron cores in human liver ferritin and its pharmaceutically important models Maltofer® and Ferrum Lek using Mössbauer spectroscopy

Studies of human liver ferritin and its pharmaceutically important models Maltofer® and Ferrum Lek were carried out using Mössbauer spectroscopy with a high velocity resolution at 295 and 90 K and Mössbauer spectroscopy with a low velocity resolution at 40 and 20 K. The Mössbauer spectra fits using a multi-component model confirm the hypothesis of the complicated heterogeneous structure of nanosized iron cores in the investigated samples. © 2013 Allerton Press, Inc

Structural and magnetic study of the iron cores in iron(III)-polymaltose pharmaceutical ferritin analogue Ferrifol®

Iron(III)-polymaltose pharmaceutical ferritin analogue Ferrifol® was investigated by high resolution transmission electron microscopy (HRTEM), X-ray diffraction, thermogravimetry, electron magnetic resonance (EMR) spectroscopy, dc magnetization measurements and 57Fe Mössbauer spectroscopy to get novel information about the structural arrangement of the iron core. The Ferrifol® Mössbauer spectra measured in the range from 295 to 90 K demonstrated non-Lorentzian two-peak pattern. These spectra were better fitted using a superposition of 5 quadrupole doublets with the same line width. The obtained Mössbauer parameters were different and an unusual line broadening with temperature decrease was observed. Measurements of the Ferrifol® Mössbauer spectra from 60 to 20 K demonstrated a slow decrease of magnetic relaxation in the iron core. Zero-field-cooled and field-cooled magnetization measurements revealed a blocking temperature at ~33 K and paramagnetic state of the Ferrifol® iron core at higher temperatures. Isothermal magnetization measurements at 5 K show that the saturation magnetic moment is ~0.31 emu/g. X-band EMR spectroscopy measurements revealed the presence of different magnetic species in the sample. Transmission electron microscopy demonstrated that the size of the iron cores in Ferrifol® is in the range 2–6 nm. The lattice periodicity in these iron cores, measured on the HRTEM images, appeared to be vary in the range 2.2–2.7 Å. This can be best understood as sets of close packed O(OH) layers in ferrihydrite cores without long range correlation

Восстановление нейромышечной проводимости после хирургической операции

Results of the research on reversal by Neostigmine and suggamadex of neuromuscular block, induced by amino steroid myo-relaxants during emergency surgical interventions. Importance of the neuromuscular monitoring during Anesthesia is discussed.Представлены результаты исследования по устранению прозерином и брайданом нейромышечного блока, индуцированного аминостероидными миорелаксантами во время экстренных хирургических вмешательств. Рассмотрена целесообразность мониторинга нейромышечной проводимости в комплексе анестезиологического пособия

Study of the Iron State in Pharmaceutical Products Using Mössbauer Spectroscopy

This work is devoted to study of the iron state in iron-containing pharmaceuticals using Mössbauer spectroscopy. Obtained results showed useful application of Mössbauer spectroscopy for characterization of the iron state in various pharmaceutical products.The authors wish to thank Dr. I. N. Antsigin for useful comments and support. This work was supported by the Ministry of Science and Higher Education of the Russian Federation, project # FEUZ-2020-0060

Lysogenic System of Non-Epidemic Cholera Vibrio El Tor, Resistant to Diagnostic Bacteriophage CTX-

Studied are non-epidemic strains of V. cholerae O1 biovar El Tor taken from the National collection of pathogenic bacteria lodged at the Russian Research Anti-Plague Institute Microbe, which were not sensible to diagnostic cholera bacteriophage El Tor ctx- at the time of isolation. Represented are the results of investigation regarding a cause of a phage-resistance of these cultures using specialized test-system consisting of indicator strains. Identified is the carriage of temperate phages among 88,0 % of the cultures examined

Prospective Sorption Matrices for Antitoxic Cholera Enterosorbent Constructing

Demonstrated is the possibility of constructing of oral anti-cholera preparations based on sorption matrices with immobilized specific ligand. Various enterosorbents (activated charcoal, polysorb, polyfepan, and chitosan) have been used as sorption matrices, cholera antitoxic immunoglobulins (ATIg) – as specific ligands. Toxin-neutralizing activity of the ATIg immobilized on polysorb has been observed in vivo in 1:64000 dilutions and that of ATIg immobilized on activated charcoal, polyfepan, and chitosan – in 1:32000. Their specific activity in vitro has been defined in dot-blot immunoassay in 1:10000 and 1:5000 dilutions, respectively. High toxin-neutralizing activity, as well as specific one has proved the suitability of all tested matrices for antitoxic cholera enterosorbents constructing. However, polysorb and chitosan are accepted to be the most prospective matrices in view of the studied characteristics and properties. To stabilize the properties of the obtained experimental prototype sorbents, AT/Ig-polysorb and AT/Ig-chitosan, applied has been the method of liophilisation with glycocol stabilizer. Dried samples retain their original biological properties