Phase-space distribution of unbound dark matter near the sun

Journal ArticleWe resolve discrepancies in previous analyses of the flow of collisionless dark matter particles in the Sun's gravitational field. We determine the phase-space distribution of the flow both numerically, tracing particle trajectories back in time, and analytically, providing a simple correct relation between the velocity of particles at infinity and at the Earth.We use our results to produce sky maps of the distribution of arrival directions of dark matter particles on Earth at various times of the year. We assume various Maxwellian velocity distributions at infinity describing the standard dark halo and streams of dark matter.We illustrate the formation of a ring, analogous to the Einstein ring, when the Earth is directly downstream of the Sun

Phase-space distribution of unbound dark matter near the Sun

We resolve discrepancies in previous analyses of the flow of collisionless dark matter particles in the Sun's gravitational field. We determine the phase-space distribution of the flow both numerically, tracing particle trajectories back in time, and analytically, providing a simple correct relation between the velocity of particles at infinity and at the Earth. We use our results to produce sky maps of the distribution of arrival directions of dark matter particles on Earth at various times of the year. We assume various Maxwellian velocity distributions at infinity describing the standard dark halo and streams of dark matter. We illustrate the formation of a ring, analogous to the Einstein ring, when the Earth is directly downstream of the Sun.Comment: 17 pages, 10 figures (better rendered in ps than pdf

Patterns of pediatric trauma in Ramadan: an observational study

Introduction Motor vehicle crashes are a major cause of death among the Saudi population. In Ramadan, the working hours and the road traffic rush hours differ from other months of the year; the pattern of trauma may also differ. We compared trauma in the pediatric age group in Ramadan with non-Ramadan months in terms of frequency, patterns, and severity.Methods We conducted a retrospective study, which included all pediatric trauma cases, from 2001 to 2009, who were registered in King Abdulaziz Medical City Trauma Registry. Trauma patterns were divided into two groups according to the date of occurrence: victims in Ramadan versus victims in non-Ramadan.Results A total of 3766 patients were included. The average number of trauma per month was 39.2 versus 44 for non-Ramadan and Ramadan months, respectively (P = 0.79). The mean patient age in Ramadan was 8.04 years compared with 8.07 years in non-Ramadan months (P = 0.037). Blunt trauma was the most common type in both groups. The median of the Injury Severity Score was the same and equal to 4. In both groups, neurological and vascular injuries were more common in Ramadan: P = 0.02 and P = 0.03 respectively.Conclusion There were no significant differences between trauma in Ramadan and non-Ramadan months, except for the higher percentage of vascular and neurological injuries in Ramadan.Key words: children, head injury, motor vehicle accidents, Ramadan, Saudi, trauma, vascular injur

The Utility of Point-of-Care Ultrasound (POCUS) in the Emergency Department: A Systematic Review

Point-of-Care Ultrasonography (POCUS) has increasingly become a pivotal tool in emergency medicine, offering significant improvements in diagnostic accuracy and patient care. This systematic review aims to evaluate the utility of POCUS in emergency settings, focusing on its impact on diagnostic accuracy, patient management, and the implications of POCUS training for emergency medicine residents. Following PRISMA guidelines, a comprehensive search across major databases, primarily PubMed, was conducted in November 2023. The review included clinical trials, observational studies, and controlled clinical trials, focusing on the utility of POCUS in emergency departments. Out of 305 articles identified, 8 studies met the inclusion criteria and were analyzed. The review encompassed diverse studies with a total of 1203 participants, demonstrating the effectiveness of POCUS in various emergency scenarios. Key findings include the improvement of diagnostic accuracy for conditions like acute dyspnea and Acute Decompensated Heart Failure (ADHF), the utility of POCUS in pediatric emergency care, and its role in ocular emergencies. POCUS was also found to influence patient care decisions significantly, changing diagnostic impressions and management plans. Additionally, POCUS training for emergency medicine residents led to increased ultrasound usage and improved patient management efficiency. POCUS has emerged as a transformative tool in emergency medicine, enhancing diagnostic accuracy, guiding clinical decision-making, and improving patient care outcomes. Its applications range from general emergency scenarios to specialized pediatric and ocular emergencies. The integration of POCUS training in emergency medicine residency programs is crucial for harnessing its full potential. As technology advances, POCUS is poised to continue revolutionizing patient care in emergency settings, affirming its indispensable role in modern medical practice

Enhanced Recovery After Surgery (ERAS) and the Role of Advanced Hemodynamic Monitoring

This study aimed at exploring the Enhanced Recovery After Surgery (ERAS) as a multi-modality, evidence-based approach to improving the quality of patient care after major surgery and to investigate the effectiveness of the implementation of the ERAS on the outcome measures. Therefore, the problem of this study lies in exploring the Enhanced Recovery After Surgery (ERAS) upon the role of advanced hemodynamic monitoring through examining a sample of (220) patients in two Jordanian hospitals (Jordan Hospital and the Specialty Hospital) undergoing major surgery. The study concluded that the patients had witnessed progressive outcome measures in the Improved Post-operative Morbidity Score (POMS), and the Reduced Length of Stay in Hospital, and the Reduced episodes of harm and surgical complications

LARP7 family proteins have conserved function in telomerase assembly

Understanding the intricacies of telomerase regulation is crucial due to the potential health benefits of modifying its activity. Telomerase is composed of an RNA component and reverse transcriptase. However, additional factors required during biogenesis vary between species. Here we have identified fission yeast Lar7 as a member of the conserved LARP7 family, which includes the Tetrahymena telomerase-binding protein p65 and human LARP7. We show that Lar7 has conserved RNA-recognition motifs, which bind telomerase RNA to protect it from exosomal degradation. In addition, Lar7 is required to stabilise the association of telomerase RNA with the protective complex LSm2-8, and telomerase reverse transcriptase. Lar7 remains a component of the mature telomerase complex and is required for telomerase localisation to the telomere. Collectively, we demonstrate that Lar7 is a crucial player in fission yeast telomerase biogenesis, similarly to p65 in Tetrahymena, and highlight the LARP7 family as a conserved factor in telomere maintenance

Effectiveness and safety of edoxaban versus warfarin in patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis of observational studies

Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia type. Patients with AF are often administered anticoagulants to reduce the risk of ischemic stroke due to an irregular heartbeat. We evaluated the efficacy and safety of edoxaban versus warfarin in patients with nonvalvular AF by conducting an updated meta-analysis of real-world studies.Methods: In this comprehensive meta-analysis, we searched two databases, PubMed and EMBASE, and included retrospective cohort observational studies that compared edoxaban with warfarin in patients with nonvalvular AF from 1 January 2009, to 30 September 2023. The effectiveness and safety outcomes were ischemic stroke and major bleeding, respectively. In the final analysis, six retrospective observational studies involving 87,236 patients treated with warfarin and 40,933 patients treated with edoxaban were included. To analyze the data, we used a random-effects model to calculate the hazard ratio (HR).Results: Patients treated with edoxaban had a significantly lower risk of ischemic stroke [hazard ratio (HR) = 0.66; 95% confidence interval (CI) = 0.61–0.70; p < 0.0001] and major bleeding (HR = 0.58; 95% CI = 0.49–0.69; p < 0.0001) than those treated with warfarin. The sensitivity analysis results for ischemic stroke and major bleeding were as follows: HR = 0.66; 95% CI = 0.61–0.70; p < 0.0001 and HR = 0.58; 95% CI = 0.49–0.69; p < 0.0001, respectively.Conclusion: Our findings revealed that edoxaban performed better than warfarin against major bleeding and ischemic stroke

Charge amplification concepts for direction-sensitive dark matter detectors

Direction measurement of weakly interacting massive particles in time-projection chambers can provide definite evidence of their existence and help to determine their properties. This article demonstrates several concepts for charge amplification in time-projection chambers that can be used in direction-sensitive dark matter search experiments. We demonstrate reconstruction of the 'head-tail' effect for nuclear recoils above 100keV, and discuss the detector performance in the context of dark matter detection and scaling to large detector volumes.Comment: 15 pages, 9 figure