1 research outputs found
Benefits of a Dual Chemical and Physical Activation: Direct aza-Michael Addition of Anilines Promoted by Solvent Effect under High Pressure
The unique combination of hexafluoroisopropanol
(HFIP) employed
as solvent and hyperbaric conditions (10–15 kbar) allows unprecedented
1,4-addition of poor nucleophiles, such as aromatic amines, onto sluggish
(cumbersome) Michael acceptors without any promoter or workup