75 research outputs found
Análise da mutação BRCA2 c.156_157insAlu em famílias com critérios de Síndrome de predisposição hereditária ao câncer de mama e ovário no Sul do Brasil
Análise in silico de variantes de significado incerto no gene ATM identificadas em indivíduos com critérios clínicos para a síndrome de predisposição hereditária ao câncer de mama e ovário
Prevalência da mutação BRCA1 5382insC em pacientes com história pessoal e/ou familiar de câncer de mama bilateral
Reassessment of BRCA1/2 variants of unknown significance : an analysis using different classification guidelines
Tempo de reclassificação de variantes de significado incerto na investigação de síndromes hereditárias de predisposição ao câncer
Clinical and molecular characterization of patients fulfilling Chompret criteria for Li-Fraumeni syndrome in Southern Brazil
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome caused by pathogenic germline variants in the TP53 gene, characterized by a predisposition to the development of a broad spectrum of tumors at an early age. The core tumors related to LFS are bone and soft tissue sarcomas, premenopausal breast cancer, brain tumors, adre nocortical carcinomas (ACC), and leukemias. The revised Chompret criteria has been widely used to establish clinical suspicion and support TP53 germline variant testing and LFS diag nosis. Information on TP53 germline pathogenic variant (PV) prevalence when using Chom pret criteria in South America and especially in Brazil is scarce. Therefore, the aim of this study was to characterize patients that fulfilled these specific criteria in southern Brazil, a region known for its high population frequency of a founder TP53 variant c.1010G>A (p. Arg337His), as known as R337H. TP53 germline testing of 191 cancer-affected and indepen dent probands with LFS phenotype identified a heterozygous pathogenic/likely pathogenic variant in 26 (13.6%) probands, both in the DNA binding domain (group A) and in the oligo merization domain (group B) of the gene. Of the 26 carriers, 18 (69.23%) were R337H het erozygotes. Median age at diagnosis of the first tumor in groups A and B differed significantly in this cohort: 22 and 2 years, respectively (P = 0.009). The present study shows the clinical heterogeneity of LFS, highlights particularities of the R337H variant and underscores the need for larger collaborative studies to better define LFS prevalence, clinical spectrum and penetrance of different germline TP53 pathogenic variants
Screening and characterization of BRCA2 C.157_157insalu in Brazil: results from 1380 individuals
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