21 research outputs found
CORRECTING OF ANEMIA USING IRON SUCROSE IN PATIENTS WITH CHRONIC KIDNEYDISEASE STAGE VD ON HEMODIALYSIS
Anemia is a common complication of CKD. Iron deficiency is one of a leading cause of anemia in HD patients. The causes of iron deficiency in these patients are multifactorial. Main factors that contribute to iron deficiency in HD patients are reduction intake and impaired intestinal absorption of dietary iron, blood losses, chronic inflammation and increased iron requirements during therapy with erythropoiesis–stimulating agents.
Aim.The aim was to study efficacy and safety of iron sucrose (Venofer) in HD patients with anemia.
Materials and methods. This study was an retrospective, epidemiologic, performed from 2010 to 2014 years. The study included 69 HD patients with anemia from dialysis single–center. 38 (55.1%) patients were men, average age 49,53 ± 3,9years and the most common cause of ESRD was glomerulonephritis (37 patients, 53.6%). Hemoglobin value was analyzed weekly. The levels of serum ferritin and transferrin saturation, were determined before and after treatment with Venofer.
Results. Treatment with the Venofer resulted a significant increase of hematological and iron exchange parameters. At 2 – 3 weeks of therapy, hemoglobin levels increased by 7,6% and 10,7%, respectively. 14 days after the last dose Venoer serum ferritin and transferrin saturation levels have increased by 58% and 55%, respectively.
Conclusions. Intravenous iron is the preferred route of administration in HD patients. Venofer showing a significant increase both of hemoglobin and iron exchange markers levels on a background of insignificant frequency of treatment–related adverse events
ANALYSIS OF THE MORTALITY STRUCTURE IN HEMODIALYSIS PATIENTS
Studies of the mortality structure in patients receiving hemodialysis (HD) remain relevant and are the basis for developing measures and recommendations directed to increase the lifetime of patients.
Aim. The aim was to study the assessment of death causes in patients who received programmed hemodialysis, based on the demographic and gender characteristics, the duration of dialysis treatment.
Methods. Mortality causes in 137 patients who received programmed hemodialysis from 2007 to 2011 years in Kyiv City Scientific and Practical Center of Nephrology an Dialysis were analyzed.
Results. The leading cause of death was cardiovascular complications, but their decreasing has been observed since 2008. Fatality rate in young and middle- aged women with cardiovascular diseases (CVD) was almost two times higher than that of men. At the same time CVD is a predominant cause of men’s death at the age older than 44. Cerebrovascular complications were permanently in the second place of the mortality structure. About 30% of deaths occurred during the first 90 days of HD treatment, 72,5% of them were among males.
Conclusion. Gender characteristics influence the structure of death causes in patients received programmed hemodialysis depending on age
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiation capacity into both hepatocytes and ductal cells. However, the molecular mechanisms by which adult ductal-committed cells acquire cellular plasticity, initiate organoids and regenerate the damaged tissue remain largely unknown. Here, we describe that ductal cells undergo a transient, genome-wide, remodelling of their transcriptome and epigenome during organoid initiation and in vivo following tissue damage. TET1-mediated hydroxymethylation licences differentiated ductal cells to initiate organoids and activate the regenerative programme through the transcriptional regulation of stem-cell genes and regenerative pathways including the YAP-Hippo signalling. Our results argue in favour of the remodelling of genomic methylome/hydroxymethylome landscapes as a general mechanism by which differentiated cells exit a committed state in response to tissue damage.RCUK
Cancer Research UK
ERC
H2020
Wellcome Trus
A clinical case of paresthesia due to amalgam retrograde filling disseminated in the upper jaw and soft tissues
Periradicular interventions are among the most common in endodontic surgery. In cases where the apical third of the root canal can not be cleaned and filled in advance by the conventional anterograde method, the apical resection is finished by cavity preparation and retrograde filling placement. Amalgam usage as a retrograde filler results in many complications. The present article reports a similar clinical case. The disadvantages of amalgam were discussed. The new materials designed for root canal treatment should meet numerous requirements. Usage of new methods and materials could eliminate the need of apicoectomy and retrograde filling.Scripta Scientifica Medica 2012; 44(2): 97-101
Use of a special bioreactor for the cultivation of a new flexible polyurethane scaffold for aortic valve tissue engineering
BACKGROUND: Tissue engineering represents a promising new method for treating heart valve diseases. The aim of this study was evaluate the importance of conditioning procedures of tissue engineered polyurethane heart valve prostheses by the comparison of static and dynamic cultivation methods. METHODS: Human vascular endothelial cells (ECs) and fibroblasts (FBs) were obtained from saphenous vein segments. Polyurethane scaffolds
Taxonomic Investigations of the Antarctic Mesophilic Strain 2BG, Producer of Secondary Metabolites
Доклади от научната сесия 70 години Медицински колеж-Варна 5 Октомври 2012
Варненски медицински форум (Varna Medical Forum) V. 1, No 1 (2012