Assessment of Concentration of TGF-ß in women with Alcohol Dependence

Alcohol disease is one of the most significant factors for development of fibrosing of the liver Fibrosing process is related to reconstruction of extracellular matrix and precedes the occurrence of cirrhosis. HSC activation is followed by production of ECM elements (2, 3, 5, 7, 8, 9, 10). In the course of fibrosing process, growth factors (mainly TGF, PDGF) and other cytokines responsible for storage, distribution and biological activity of ECM proteins, are involved (3, 11, 12,13). Among growth factors, TGF-β appears to be a key mediator in human fibrogenesis. In HSC TGF-β favors the transition to myofibroblast-like cells, stimulates the synthesis of ECM proteins, and inhibits their degradation. Liver fibrosis is a result of chronic damage to the liver conjunction with the accumulation of ECM proteins, which is a characteristic of most types of chronic liver diseases. Material and methods. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammaglutamyltransferase (GTP) transforming growth factor beta (TGF-B) were investigated during this study. Study group consists of 40 inpatients treated in Inpatients Clinic in Toruń. Control group consists of 35 healthy women. Results. Mean age of females in the study group was 43+/-7 yrs, length of dependence 8+/-6 yrs, AST 32,88+/- 32,95, ALT 29,76+/-24,48, GTP 57,21+/-128,4 U/l. The concentration of TGF-β was significantly higher in alcohol dependent female group compared to the healthy subjects (683,45 vs 69,18; p=0,028). Conclusions`. These results imply that prolonged alcohol abuse leads to an increase of concentration of TGF-β as a result of hepatic cirrhosis.Choroba alkoholowa jest jednym z czynników o największym znaczeniu dla rozwoju włóknienia wątroby. Patomechanizm włóknienia wątroby jest taki sam niezależnie od etiologii, próbuje się wiec prowadzić próby monitorowania przebiegu patologii wątroby wyrażanej również jako włóknienie tego narządu u osób nadużywających alkoholu poprzez oznaczanie stężenia niektórych składników macierzy pozakomórkowej(extracellular matrix - ECM) lub produktów ich metabolizmu we krwi. Wielopłaszczyznowość i złożoność czynników biorących udział, leżących u podstaw tak procesu włóknienia jak i regeneracji powoduje poszukiwanie wskaźników najlepiej oddających diagnostycznie stan zaawansowania schorzenia. Spośród wielu cytokin wpływających na aktywacje HSC wydaje się największe przypisuje się TGF-ß (transforming growth factor ß) Celem niniejszej pracy była ocena stężenia TGF-ß u pacjentek z zza i próba oceny jego użyteczności diagnostycznej w ocenie stanu wątroby u osób z zza. Badaniami objęto grupę 40 kobiet z zza leczonych w WOTUiW(Wojewódzki Ośrodek Terapii Uzależnień i Współuzależnień) w Toruniu. Badane kobiety nie były uzależnione od innych prócz alkohol( z wyjątkiem nikotyny) substancji psychoaktywnych; średni wiek 43 lata, średni czas uzależnienia 8 lat. Grupę kontrolną stanowiło 35 zdrowych kobiet. U badanych wykonano oznaczenia aktywności AST, ALT, GTP, stężenia TGF-ß. Wiek pacjentek wynosił 43+/-7 lat, czas uzależnienia 8+/-6 lat, aktywność enzymów (U/l): AST 32,88+/-32,95, ALT 29,76+/-24,48, GTP 57,21+/-128,4 U/l. Stężenie TGFß było znamiennie wyższe u kobiet z ZZA wobec kobiet zdrowych (683,45 vs 69,18; p=0,028). Dalszego wyjaśnienia wymaga prognostyczna wartość przydatność TGF-ß jako markera aktywności i chorób przebiegających z włóknieniem

Ocena Stężenia Transformującego Czynnika Wzrostu (Tgf-ß) W Surowicy Krwi Kobiet Uzależnionych Od Alkoholu

Alcohol disease is one of the most significant factors for development of fibrosing of the liver Fibrosing process is related to reconstruction of extracellular matrix and precedes the occurrence of cirrhosis. HSC activation is followed by production of ECM elements (2, 3, 5, 7, 8, 9, 10). In the course of fibrosing process, growth factors (mainly TGF, PDGF) and other cytokines responsible for storage, distribution and biological activity of ECM proteins, are involved (3, 11, 12,13). Among growth factors, TGF-β appears to be a key mediator in human fibrogenesis. In HSC TGF-β favors the transition to myofibroblast-like cells, stimulates the synthesis of ECM proteins, and inhibits their degradation. Liver fibrosis is a result of chronic damage to the liver conjunction with the accumulation of ECM proteins, which is a characteristic of most types of chronic liver diseases.Material and methods. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammaglutamyltransferase (GTP) transforming growth factor beta (TGF-B) were investigated during this study. Study group consists of 40 inpatients treated in Inpatients Clinic in Toruń. Control group consists of 35 healthy women.Results. Mean age of females in the study group was 43+/-7 yrs, length of dependence 8+/-6 yrs, AST 32,88+/- 32,95, ALT 29,76+/-24,48, GTP 57,21+/-128,4 U/l. The concentration of TGF-β was significantly higher in alcohol dependent female group compared to the healthy subjects (683,45 vs 69,18; p=0,028).Conclusions`. These results imply that prolonged alcohol abuse leads to an increase of concentration of TGF-β as a result of hepatic cirrhosis.Choroba alkoholowa jest jednym z czynników o największym znaczeniu dla rozwoju włóknienia wątroby. Patomechanizm włóknienia wątroby jest taki sam niezależnie od etiologii, próbuje się wiec prowadzić próby monitorowania przebiegu patologii wątroby wyrażanej również jako włóknienie tego narządu u osób nadużywających alkoholu poprzez oznaczanie stężenia niektórych składników macierzy pozakomórkowej(extracellular matrix - ECM) lub produktów ich metabolizmu we krwi.Wielopłaszczyznowość i złożoność czynników biorących udział, leżących u podstaw tak procesu włóknienia jak i regeneracji powoduje poszukiwanie wskaźników najlepiej oddających diagnostycznie stan zaawansowania schorzenia.Spośród wielu cytokin wpływających na aktywacje HSC wydaje się największe przypisuje się TGF-ß (transforming growth factor ß)Celem niniejszej pracy była ocena stężenia TGF-ß u pacjentek z zza i próba oceny jego użyteczności diagnostycznej w ocenie stanu wątroby u osób z zza . Badaniami objęto grupę 40 kobiet z zza leczonych w WOTUiW(Wojewódzki Ośrodek Terapii Uzależnień i Współuzależnień) w Toruniu.Badane kobiety nie były uzależnione od innych prócz alkohol( z wyjątkiem nikotyny) substancji psychoaktywnych; średni wiek 43 lata, średni czas uzależnienia 8 lat. Grupę kontrolną stanowiło 35 zdrowych kobiet. U badanych wykonano oznaczenia aktywności AST , ALT, GTP, stężenia TGF-ß.Wiek pacjentek wynosił 43+/-7 lat, czas uzależnienia 8+/-6 lat, aktywność enzymów (U/l): AST 32,88+/-32,95, ALT 29,76+/-24,48 , GTP 57,21+/-128,4 U/l. Stężenie TGFß było znamiennie wyższe u kobiet z ZZA wobec kobiet zdrowych (683,45 vs 69,18; p=0,028).Dalszego wyjaśnienia wymaga prognostyczna wartość przydatność TGF-ß jako markera aktywności i chorób przebiegających z włóknieniem

Intraoperative imagining in breast cancer surgery

Breast cancer is the most common cancer in the female population. It is the second leading cause of cancer death in this population. The current technique of nuclear medicine combined with oncological surgery requires the improvement of known imaging methods. In addition to generally available methods, such as MRI, CT, PET or mammography, scientists try to modify the diagnostic process and treatment of the patient in such a way that it is as effective and the least harmful as possible. Breast cancer surgery is experiencing an infamous boom due to the increase in diagnoses, but looking at the positive side, it is also experiencing an amazing development: clinical and technological. Increasingly, surgeons are accompanied by nuclear medicine, which precisely defines the methods of excision of breast tumors with a margin, while giving  a satisfactory cosmetic effect, which is especially important for women. Thanks to the development of these two fields, it is becoming easier to identify specific sentinel lymph nodes (SLNs) that require resection during surgical treatment and to suggest postoperative treatment. The progress of science and medicine has undoubtedly contributed to the development of methods of intraoperative imaging in breast cancer. Today, practically simultaneously in the conditions of the operating room, a multidisciplinary team can determine the area of resection faster and more accurately. Based on the research, it was decided to compare several methods used in today's advanced breast cancer surgery, supported by nuclear medicine

How electronic devices affect the sleep of young people: summary of current knowledge

Introduction and purpose: The impact of electronic devices on our daily lives is becoming increasingly significant. The contemporary generation of young people is growing up in a world where smartphones, tablets, computers, and other electronic devices are widely available and utilized. Scientists are contemplating the challenges posed by excessive exploitation of electronics on the health of young individuals. The aim of the article is to present the harmful effects of using electronic devices before sleep in young people, considering medical aspects such as sleep disorders and their influence on overall psychophysical health. Summary: Electronic devices negatively affect the sleep of young people by reducing sleep time and delaying the sleep onset phase. The main problem is the use of electronic devices without time limits. In the era of technology, it is significantly important to raise awareness among young people about the importance of sleep hygiene and how blue light emitted by electronic devices affects its quality

Tracheotomy as a life-saving procedure - overview of the current knowledge

Tracheotomy as a life-saving procedure has been known for many thousands of years. Tracheotomy remains one of the most frequently performed surgical procedures in the course of acute respiratory failure. Tracheostomy is traditionally performed as an open surgical procedure, performed both in the operating room and at the patient's bedside. Before performing the procedure, the thyroid cartilage and soft tissues are palpated. Before the operation, the patient lies on his back with a roller placed under the shoulder blades and his head tilted back. Direct and indirect laryngotracheoscopy is performed, and in doubtful situations we use computed tomography.General indications for tracheostomy are acute respiratory failure with anticipated need for prolonged mechanical ventilation and inability to wean off from mechanical ventilation, upper airway obstruction, and profuse secretions. Tracheostomy may have a beneficial effect on refractory obstructive sleep apnea. The percentage of late complications after the procedure reaches even 65%. The aim of the article is to present information on tracheostomy: its techniques, indications, contraindications, possible complications and decannulation of the patient

Sauna use as an activity leading to a reduction in modifiable risk factors for the development of hypertension - a systematic review

Background: Hypertension prevalence is disturbingly increasing all over the world. Clinicians and patients are looking for new pharmacological as well as non-pharmacological methods to help fight too-high blood pressure.    Aim of this study:  The aim of this study is to present the current scientific literature on the potential that sauna bathing may help lower blood pressure, but additional data are needed to confirm these findings.   Material and methods:  A systematic review of the scientific and medical literature from the PubMed and Google Scholar databases was carried out. This was achieved according to the keywords: hypertension, sauna and sauna bathing. Items of literature were qualified for analysis.    State of knowledge:  Using the sauna is a pleasant way to spend time, and additionally it can have an impact on lowering blood pressure. During a sauna session, the superficial vessels dilate, which leads to a short-term decrease in blood pressure. And long-term, more frequent sauna use leads to a reduced risk of hypertension. Using the sauna enhances the effect of pharmacotherapy and non-pharmacological methods of fighting hypertension, such as physical activity and a healthy, balanced diet. Most of the research on the above topic was conducted in Finland, where its use has a centuries-old tradition.  Summary:  Using the sauna has an impact on lowering blood pressure values, thanks to which it can support the treatment of hypertension. Sauna use may be an interesting way to lower blood pressure values in physically disabled people. More studies conducted on larger groups of patients and the influence of other factors on blood pressure values are needed to make more accurate recommendations

Efficacy and potential use of vitamin D in the prevention and treatment of uterine fibroids

Introduction: Uterine fibroids (UFs) are the most common benign gynecological tumors. Pharmacological and/or surgical treatments are frequently required, depending on the woman's desire to preserve fertility. Due to side effects caused by pharmacological and surgical treatments, there is a growing interest in a safe approach for UFs. In recent years, hypovitaminosis D is believed to be a major risk factor in the development of a tumor. Studies proved vitamin D efficacy in inhibiting UFs growth by targeting pathways involved in the regulation of various biological processes, resulting in inhibition of tumor cell division and a significant reduction in its size. Vitamin D seems to be promising, effective, and low-cost method in the management of UFs and their clinical symptoms. Aim of the study: This article reviews the state of knowledge based on available studies. The aim of the study is to present the most important informations about effectiveness and potential usage of vitamin D in prevention and treatment of uterine fibroids. Material and methods: The authors created a paper summarizing review of currently available publications based on databases such as PubMed, Scopus and Google Scholar

The ketogenic diet in schizophrenia

Schizophrenia is a mental illness that manifests itself in the second or third decade of life with no coherent aspect. The primary pharmacological therapy is antipsychotic medication, which mostly work by suppressing the activity of dopamine. Unluckily, many of schizophrenic patients experience hardship from severe positive or negative symptoms that can not be completely treated with available treatment. Last theory of schizophrenia mechanism contain systemic and central proinflammatory process, in brain glutamatergic neurotransmission and impaired systemic and cerebral energy metabolism. Ketogenic diet is firm controlled high-fat, low protein, low-carbohydrate diet, with lipid to non lipid ratio 4:1. Main mechanism is to cause ketosis. The situation in which ketones bodies are used as a substrate to generate energy in the organism. It could be that a ketogenic diet could help to compensate for the imbalance of GABA levels in schizophrenic brain. The ketogenic diet as an addition to drug treatment, hopefully may offer therapeutic opportunities to better result of the disease concerning symptomatology and preventing the gain of weight, due to some medication side effects or comorbidities

Non-surgical treatments for androgenetic alopecia: a literature review

Androgenetic alopecia is the most common type of hair loss and affects at least 80% of men and half of women before the age of 70, with the incidence increasing with age. Androgenetic alopecia is an ailment conditioned by genetic and hormonal factors, associated with excessive stimulation of the androgen receptor in the cells of the hair follicle. With the development of medicine, more and more therapeutic methods for androgenetic alopecia appear on the market, including minoxidil, 5-α-reductase inhibitors, microneedling, platelet-rich plasma, low-energy laser therapy, rosemary oil, or siRNA. Thanks to the constantly growing amount of scientific research, progressively more is known about the mechanisms of androgenetic alopecia development and potential strategies to stop it. The article analyzes the literature using electronic databases and textbooks to compile methods that can be an effective alternative for people who do not want to undergo surgery. Some of the methods presented in the article have the potential to not only slow down, but also reverse the progression of the disease. However, each of them still has its limitations

Retzius-Sparing Robot-Assisted Radical Prostatectomy in treatment of prostate cancer – presentation of the method and results

Background: Prostate cancer is a malignant cancer and the second most frequent malignancy in men. Millions of people are suffering from this problem across the globe. The gold standard for the treatment of this disease is considered radical prostatectomy. This method can lead to a complete cure but is not free of complications. Retzius-sparing modification of robot-assisted radical prostatectomy is a new method that can contribute to better results in faster recovery. Aim of this study: To present the difference between the Retzius-Sparing Robot-Assisted Radical Prostatectomy (RS-RARP) and the Standard Robot-assisted Radical Prostatectomy (S-RARP) in method and results. Materials and methods: A review was conducted in PubMed and Google Scholar including publications from the last 9 years. Literature was searched using the following terms: “Retzius-sparing”, “robot-assisted radical prostatectomy” and “prostate cancer”. Results and conclusion: Retzius-Sparing Robot-Assisted Radical Prostatectomy is a relatively new method that can improve results in prostate cancer treatment. In analyzed original articles RS-RARP compared to s-RARP showed better recovery of continence and lower risk of hernia. Although there were no significant differences in postoperative sexual function, positive surgical margins, and 1-year-biochemical recurrence rate